🔬 Molecular Neurodegeneration research group at Tel Aviv University, Israel
Joined February 2019
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25 Nov 2021
In our recent paper we show that TDP43 mislocalization and condensates in axons and neuromuscular junction cause Neurodegenration in ALS by inhibiting local synthesis of mitochondrial proteins nature.com/articles/s41467-0…
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Jun 11
RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons jneurosci.org/content/44/15/…
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Jun 9
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive weakness due to degeneration of upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord.
Learn more in this Review: ja.ma/3Q8S0jq
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Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation | EMBO Reports | Springer Nature Link link.springer.com/article/10…
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Mar 20
Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain - Walker - 2026 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/…
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Feb 11
Mecca et al. investigate the role of muscle stem cells in SMA and show that their depletion disrupts neuromuscular junctions and leads to motor neuron loss in the spinal cord. They conclude that muscle stem cells represent potential therapeutic targets. shorturl.at/vIwEU
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12 Nov 2025
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
embopress.org/doi/full/10.10…
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12 Nov 2025
Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo
researchsquare.com/article/r…
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8 Nov 2025
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons | The EMBO Journal embopress.org/doi/full/10.10…
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2 Nov 2025
KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS biorxiv.org/content/10.1101/… #biorxiv_neursci
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31 Oct 2025
Cell size-dependent mRNA transcription drives proteome remodeling biorxiv.org/content/10.1101/…
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30 Oct 2025
Read this excellent story from the @jltwiss1 lab. Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration biorxiv.org/content/10.1101/…
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23 Oct 2025
O'Brien et al. demonstrate a link between ALS and extreme exercise in males which is potentially mediated via failed mTOR signalling at the neuromuscular junction. tinyurl.com/cajta7y3; tinyurl.com/ymd5c6h4
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23 Oct 2025
Drs. Yi Zeng, Aaron Gitler, and colleagues show that loss of TDP-43 from neuronal nuclei of human brain and disease-causing mutations in TDP-43 are associated with widespread changes in alternative polyadenylation. 🧠 @StanfordMed
@NatureNeuro | go.nature.com/473g5Oe
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22 Oct 2025
Retrotransposons unplugged: Rewiring the nervous system and wreaking havoc: Neuron cell.com/neuron/fulltext/S08…
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17 Oct 2025
Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse model of amyotrophic lateral sclerosis: biorxiv.org/content/10.1101/…
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5 Oct 2025
Our cover art suggestion. Firefighters spraying mir126 balloons to douse the flames- toxic TDP-43 aggregates that damage axons and neuromuscular junction in ALS. Illustration by Maayan Visuals. nature.com/articles/s41593-0…
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5 Oct 2025
Thrilled to share our new work in Nature Neuroscience!
Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS.
nature.com/articles/s41593-0…
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5 Oct 2025
By uncovering a new mechanism that drives ALS progression and identifies a potential therapeutic target, we hope this work opens up new avenues for intervention.
Grateful to my brilliant team and collaborators for making this possible.
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This reveals a novel muscle-to-motor neuron communication axis, where loss of miR-126 triggers TDP-43 accumulation, NMJ disruption, and motor decline. Restoring miR-126 demonstrated neuroprotective effects in both mouse and human ALS models.
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3 Oct 2025
Translation landscape of stress granules | Science Advances science.org/doi/10.1126/scia…
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