Professor @_amolf. The dynamics of single proteins. But now also the dynamics of organoid development. Not always Sander tweeting.

Joined December 2011
17 Photos and videos
Today our (me Jeroen van Zon's lab) new 3D cell tracking software is out on biorXiv (biorxiv.org/content/10.1101/…). Our student @MaxBetjes presents, what we think, is a fundamental advance in cell tracking: An algorithm that accurately quantifies the uncertainty of its results. 1/10
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Our software is available, with lots of documentation and manuals on jvzonlab.github.io/OrganoidT…, we maintain the software together with the indispensable @rutger_kok at @MariaRodrColman 's lab. 10/10

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Bonus: The neural networks trained on our intestinal organoid data exhibit strong out-of-sample capabilities. For instance, we recently used them to track a blastocyst imaged by @JunyentSergi at the Zernicka-Goetz lab from the 16 to 64-cell stage.
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We just opened several positions (PhD and postdoc) on ribosome cooperation - studied with advanced single-molecule techniques. You will also work with Genome-wide profiling and Cryo-EM through a fun international collaboration! Check out: sandertanslab.nl
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Looking for a PhD or Postdoc position on AI methods and experiments on organoids at the cellular level? The Tans and Van Zon labs @ AMOLF Amsterdam now have multiple openings on this topic at the interface between biology and physics. Interested? sandertanslab.nl
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Our TypeTracker paper is now out in @ScienceAdvances: science.org/doi/10.1126/scia…. Super proud on the truly excellent work of our former PhD-student @XuanZheng2016, that shows early fate commitment preceding cell cycle exit and spatial patterning in intestinal organoids (1/8):
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Much more can be found in this paper of course, like these cool graphs, where we also plot the spatial position of cells in the lineage tree: (7/8)
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Many thanks to our (all this work was in joint collaboration with Jeroen van Zon @_amolf) co-authors and collaborators; @MaxBetjes @PascalEnder Guizela Huelsz-Prince @HansClevers (8/8)
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