@SchertzerLab profile picture
Jonathan Schertzer (SchertzerLab) @SchertzerLab

Immunometabolism research: Diet, microbes, drugs and hormones

Joined December 2012
  • Tweets 2,220
  • Following 748
  • Followers 1,460
24 Photos and videos
Xenophagocytosis blockade enhances interspecies chimerism sciencedirect.com/science/ar…
1
188
Advancing precision health discovery in a genetically diverse health system cell.com/cell/fulltext/S0092…

Advancing precision health discovery in a genetically diverse health system

The UCLA ATLAS biobank was utilized to integrate genetic data with electronic health records from individuals representing five continental and 36 fine-scale ancestries, identifying genotype-phenot...

cell.com
1
3
193
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory science.org/doi/10.1126/scie…

Distinctive DNA sequence features define epigenetic longevity of inflammatory memory

Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understo...

science.org
1
3
219
Jonathan Schertzer (SchertzerLab) retweeted
AJP-Endocrinology and Metabolism@AJPEndoMetab
Mar 24
Take a short break to review today's Mini-Review #ArticleinPress, Immunometabolism of IRF4 in Adipose, #Muscle, and Immune Cells Influences #Obesity and MASLD (Daniel Marko and Jonathan Schertzer @McMasterU): ow.ly/BCin50Yyghs
2
17
787
Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design cell.com/cell/fulltext/S0092…

Genomic atlas of Bifidobacterium infantis and B. longum informs infant probiotic design

A global genomic survey of infant gut bifidobacteria shows that B. infantis remains highly prevalent and diverse in infants from low- and middle-income countries but scarce in Western, industrialized...

cell.com
1
173
Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis cell.com/cell/fulltext/S0092…
3
182
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma cell.com/cell-host-microbe/f…

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung...

Yu et al. demonstrate that Staphylococcus is selectively enriched in metastatic lung tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote the metastatic potential of...

cell.com
2
217
Jonathan Schertzer (SchertzerLab) retweeted
Nature Metabolism
@NatMetabolism
Mar 4
TRIPping anti-tumour immunity through lactylation dlvr.it/TRHR2b

TRIPping anti-tumour immunity through lactylation

Nature Metabolism - KRAS mutations in colorectal cancers shape an immunosuppressive tumour microenvironment. In this issue of Nature Metabolism, Yang et al. report that TRIP6...

nature.com
4
16
1,863
Preprint: CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation biorxiv.org/content/10.64898…
3
256
Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease cell.com/cell-metabolism/ful…

Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-assoc...

Tang et al. reveal that high sugar intake promotes MASLD progression via microbiota-produced acetaldehyde, which drives fibrosis through MMP7 upregulation. An engineered probiotic, Ligilactobacillus...

cell.com
2
6
400
Jonathan Schertzer (SchertzerLab) retweeted
Cell Reports@CellReports
Feb 24
Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity dlvr.it/TR7qyl

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent...

Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction....

cell.com
15
53
3,846
Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity cell.com/cell-reports/fullte…

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent...

Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction....

cell.com
1
5
31
1,939
Jonathan Schertzer (SchertzerLab) retweeted
Cell Metabolism@Cell_Metabolism
Feb 23
New! Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis dlvr.it/TR6mSR
1
14
55
4,733
Hepatic adaptation to chronic metabolic stress primes tumorigenesis: Cell cell.com/cell/fulltext/S0092…

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Environmental stresses, such as a high-fat diet, disrupt liver cell balance by promoting pro-survival, developmental, and regenerative programs while impairing key tissue functions. These stress...

cell.com
1
7
484
Jonathan Schertzer (SchertzerLab) retweeted
Daniel J Drucker@DanielJDrucker
Jan 14
In humans nighttime metabolic dysfunction is a hallmark of #MASLD with multiple pathogenic pathways upregulated at night, including hepatic and peripheral insulin resistance, DNL, and systemic NEFA exposure cell.com/cell-metabolism/ful… #circadian

Human MASLD is a diurnal disease driven by multisystem insulin resistance and reduced insulin...

By studying metabolism across day and night in human participants, Marjot et al. show that MASLD is a nighttime disease driven by poor insulin action and low insulin levels. These daily patterns...

cell.com
1
15
71
4,069
Jonathan Schertzer (SchertzerLab) retweeted
Kevin Hall
@KevinH_PhD
17 Dec 2025
It was a great pleasure to meet @richroll and discuss nutrition and metabolism science on the @RichRollPodcast!
This tweet is unavailable
2
5
35
5,994
Jonathan Schertzer (SchertzerLab) retweeted
Mahla Poudineh@Mahla_Poudineh
8 Dec 2025
Great time at the #NeurIPS2025, especially the chance to discuss our collaborative work with the @SchertzerLab and @Ali_Etemad1 and to connect with AI experts pushing time-series methods for health. I really enjoyed catching up with friends and colleagues: @Zjahed, @JWangnano
2
4
28
3,219
Jonathan Schertzer (SchertzerLab) retweeted
Journal of Clinical Investigation
@jclinicalinvest
6 Dec 2025
Previously shared: Let’s GIV a NOD(2) to gut homeostasis Here, Pradipta Ghosh & team @UCSanDiego find a critical interaction between GIV and NOD2 in gut macrophages, revealing their importance in maintaining gut health and preventing inflammatory bowel diseases (#IBD): doi.org/10.1172/JCI190851 The TEM images show phagolysosomal fusion events in infected macrophages from WT mice but not those from those lacking GIV.
2
5
15
1,969
T cell cholesterol transport links intestinal immune responses to dietary lipid absorption science.org/doi/10.1126/scie…

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption

The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A...

science.org
1
1
23
3,386
Jonathan Schertzer (SchertzerLab) retweeted
Daniel J Drucker@DanielJDrucker
3 Oct 2025
Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field sciencedirect.com/science/ar…
8
158
461
31,776
Load more