Science Signaling offers researchers the most up-to-date resource for groundbreaking research and commentary in the dynamic field of cellular signaling.
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A preclinical study reveals how an enzyme named TIKI2 supports healthy cartilage biology and shows that a deficiency in TIKI2 contributes to #osteoarthritis in mice—pointing to the enzyme as a potential therapeutic target. @2024_HUST scim.ag/49AvPsU
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Jun 12
In this week’s Editors’ Choice piece, we highlight a study by Muratspahić and colleagues in @Nature, describing the design of miniproteins that target GPCRs.
Read a summary: scim.ag/4ghEODn
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Although CDK1 is best known as a regulator of specific phases of the #CellCyle, a new study unexpectedly identifies a pool of CDK1 at cell-cell junctions that supports the integrity of the epithelium during the entire cell cycle. @GloerichLab @UMCU_Intl scim.ag/4uzhbd5
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Science Signaling retweeted
New paper out in @SciSignal — and we made the cover! 🎉 We uncovered a new role for autoimmunity gene PTPN22 in shaping the T cell immunological synapse.
science.org/doi/10.1126/scis…
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How do T cells restrain their activation?
A team applies DNA-PAINT to visualize the immunological synapse and shows PTPN22 restricts actin remodeling and antigen sensitivity by interacting with PSTPIP1 at the plasma membrane. @MDJoseph97 @ssimoncelli scim.ag/4axoMl1
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A new imaging analysis uncovers an important molecular brake on T cell remodeling and activation, in vitro experiments reveal an unexpected role for the cell cycle regulator CDK1, and more this week in #ScienceSignaling. scim.ag/4fyRrts
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This issue, scientists highlight the latest research about the 4 factors that support mucosal-associated invariant T cells—and discuss findings identifying nutrient availability as a 5th pillar of MAIT cell fitness. @eimearrryan @LindaVSinclair @MuLonsdale scim.ag/3PMUWlH
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A preclinical study reveals how an enzyme named TIKI2 supports healthy cartilage biology and shows that a deficiency in TIKI2 contributes to #osteoarthritis in mice—pointing to the enzyme as a potential therapeutic target. @2024_HUST scim.ag/49AvPsU
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An in vivo and modeling analysis shows that activity of the vagus nerve has a more complex effect on insulin release than was previously thought, hinting vagus nerve stimulation may have unintended metabolic consequences. @KanazawaUniv_O @Tokushima_Univ scim.ag/3PM1sck
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Researchers have traced the molecular origins of severe pain in #neurofibromatosis—an inherited condition of tumors in the nervous system—and show that an FDA-approved drug can relieve pain in mice. @CincyChildrens @NamrataGRRaut @JankowskiLab scim.ag/4u2RtgT
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This week, scientists highlight the latest research about the 4 factors that support mucosal-associated invariant T cells—and discuss findings identifying nutrient availability as a 5th pillar of MAIT cell fitness. @eimearrryan @LindaVSinclair @MuLonsdale scim.ag/3PMUWlH
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Researchers connect #osteoarthritis to a lack of the enzyme TIKI2 in cartilage and show that TIKI2 normally supports cartilage integrity and homeostasis by promoting chondrocyte differentiation and restraining Wnt signaling pathways. @2024_HUST scim.ag/49AvPsU
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This week’s new issue of #ScienceSignaling has arrived!
A team identifies a gatekeeper of cartilage health that goes awry in osteoarthritis, a Review highlights how cell nutrition is emerging as a pillar of fitness for unconventional T cells, and more. scim.ag/4fU7pyk
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Contrary to current thinking, a new study shows that activation of the #VagusNerve results in decreased insulin release from the pancreas—and that #obesity exacerbates this dampening effect. @KanazawaUniv_O @Tokushima_Univ scim.ag/3PM1sck
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May 31
The dsDNA sensor #cGAS drives damaging immune responses and acute lung injury during infection via #phosphorylation triggered by double-stranded DNA, a rapid spike in Ca2 , and formation of cGAS condensates in endothelial cells. @dollymehtalab @uiccom scim.ag/3Rna6yk
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Recent work reveals how two proteins enhance signaling pathways mediated by receptor tyrosine kinases (RTKs) that drive many cancers and points to possible strategies to target RTK-driven #cancers that have developed resistance to RTK inhibitors. @CWRUSOM scim.ag/4unnbXd
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May 29
In this week’s Editors’ Choice piece, we highlight a study by Torborg and colleagues in @Dev_Cell, revealing insights into how Wnt signaling regulates PDAC tumor growth.
Read a summary: scim.ag/43wzjcq
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May 29
Researchers have traced the molecular origins of severe pain in #neurofibromatosis—an inherited condition of tumors in the nervous system—and show that an FDA-approved drug can relieve pain in mice. @CincyChildrens @NamrataGRRaut @JankowskiLab scim.ag/4u2RtgT
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May 28
An in vivo and modeling analysis shows that activity of the vagus nerve has a more complex effect on insulin release than was previously thought, hinting vagus nerve stimulation may have unintended metabolic consequences. @KanazawaUniv_O @Tokushima_Univ scim.ag/3PM1sck
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May 27
How does neurofibromatosis cause pain?
New work shows that #SchwannCells drive pain sensitivity in mice by secreting GDNF that activates GFR-alpha-1 on sensory neurons, which can be reversed with mirdametinib. @CincyChildrens @NamrataGRRaut @JankowskiLab scim.ag/4u2RtgT
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