The Shechner lab in UW Pharmacology. We study Noncoding RNAs and cellular architecture. He/His/Him. All comments are my own. @ShechnerLab.bsky.social
Joined September 2018
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21 Nov 2024
It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
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May 26
There’s nothing *quite* like seeing two of my favorite labs collaborating on truly beautiful work. Congrats to all involved!!
May 26
Excited to share our collaborative work with the @TonyMustoe and @SuperSciJew labs, led by the fearless @RitwikaBose15.
In this study, we developed RAID-MAP, an approach to map RNA structure within biomolecular condensates in living cells.
biorxiv.org/content/10.64898…
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May 23
Good *gravy*, that’s beautiful! Congrats too all the authors!!
First AI-generated RNA with novel atomically ordered 3D fold! With @eternagame @StanfordBiochem @chaitjo @PossuHuangLab @UWproteindesign @ShujunHe0717 @navtejtoor @HHMIJanelia on bioRxiv doi.org/10.64898/2026.05.21.…
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Mar 19
🤩🤩🤩
Mar 18
Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing.
biorxiv.org/cgi/content/shor…
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19 Sep 2025
AWESOME CONFERENCE ALERT!!
I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!
Talk abstract deadline: 10/17
Details👇
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22 Aug 2025
Nucleoli AI = NucleolAI?
Seriously, this is awesome work! Congrats to all the authors!
20 Aug 2025
I’m thrilled to share our preprint that uses deep learning to interrogate structure-function relationships in condensates! biorxiv.org/content/10.1101/… In here, we ask: can AI read condensate biology from pictures alone? Turns out yes... see what we discover below! 🤖🧬🖼️ (1/10)
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10 Jul 2025
*Huge* win for @genentech! Congrats, @DNAmyStrom!!
7 Jul 2025
I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology!
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
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8 Jul 2025
Amazing work, as always, from @Mayr_Christine’s lab. Congrats to all authors!!
7 Jul 2025
More than 2700 3′UTRs are highly conserved.
These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance.
Highly conserved 3′UTRs help the folding of proteins with long IDRs.
biorxiv.org/content/10.1101/…
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3 Jul 2025
Awesome work from the Rouhanifard lab (as per usual 😊)
2 Jul 2025
New from the Rouhanifard Lab!
What if we could sort single cells based on whether a specific gene was actively being transcribed—and then ask what drives that burst?
Introducing: NuclampFISH
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30 Jun 2025
Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @CellReports, @FKHM and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
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26 Jan 2025
🤩🤩🤩
25 Jan 2025
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31 Dec 2024
TOP FIVE METABOLIC PATHWAYS
…Based on whether they sound like the name of an old-school anime:
5. The Pentose-Phosphate Shunt
4. Peptidoglycan Degradation
3. Fatty Acid Beta-Oxidation
2. The Dark Reactions of the Calvin Cycle
1. Gluconeogenesis
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21 Dec 2024
Thank you so much for posting! And thanks to the inimitable @cellseywoodruff for the amazing writeup!!
20 Dec 2024
#RNAsequencing helps map #RNA interactions with proteins and #DNA, revealing cellular processes and disease mechanisms. The O-MAP method by the @ShechnerLab enables precise RNA neighborhood mapping for deeper insights. - @UW rna-seqblog.com/o-mapping-th…
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19 Dec 2024
Woohoo! So excited to see this important work out in print! Congrats @nandangokhale and all authors!
19 Dec 2024
Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology @RamLabUW
science.org/doi/10.1126/scie…
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23 Nov 2024
Woohoo! Congratulations @arjunrajlab for this well-deserved honor!!
21 Nov 2024
Congratulations to @arjunrajlab, Professor in #PennBioengineering, who has been named the inaugural recipient of the Richard K. Lubin Professorship by @PennEngineers.
Read more: bit.ly/4fCj4ik
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22 Nov 2024
Awesome work as always! Congrats to the whole team!!
18 Oct 2024
Our latest preprint "Sequential structure probing of cotranscriptional RNA folding intermediates" is on bioRxiv. biorxiv.org/content/10.1101/… Led by @CourtneySzyjka and anchored by Skyler Kelly, this preprint describes a method for detecting cotranscriptional RNA folding transitions.
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21 Nov 2024
It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
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21 Nov 2024
Finally, I want to highlight the beautiful work of our collaborators @oligopain and @dschweppe1, who have developed O-MAP-tools directly targeting DNA loci. Between DNA-O-MAP and nascent RNA-O-MAP, I think there's a *ton* to discover! (29/30)
tinyurl.com/2wu4ruab
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21 Nov 2024
And that's a wrap (for now)! I hope you've enjoyed this thread and give our preprint a read. Let us know what you think! (30/30)
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