Professor-@IUSMPharmTox-@IUSMneuro. My my laboratory aims to elucidate the functional organization of circuit pathways involved in pain modulation.

Joined April 2019
31 Photos and videos
NIH-FUNDED POSTDOC opening: Dissect mPFC pain circuits! HEAL R01 → ephys, in vivo Ca²⁺ imaging (miniscope/fiber photo), opto, behavior. PhD neuro/ephys preferred. Apply via Sheets Lab website (sheetslabiusm.com/openings) RTs appreciated! #Postdoc #Neuroscience #PainResearch
1
13
27
5,660
Please check out the new first author paper for grad student @reganhines18! Ozanimod and other sphingosine-1-phosphate receptor 1 modulators norma... sciencedirect.com/science/ar…

4
145
Patrick L Sheets retweeted
Huge thanks to @SheetsLabIUSM Patrick Sheets from @IUSM for a great @CAPToR_UF Seminar Series talk, “Reverse engineering mPFC circuits implicated in pain.” 🧠 It was a pleasure to host you - thank you for the inspiring insights & engaging discussion on mapping pain circuits!
1
15
372
Had an amazing time in San Diego for @SfNtweets #SfN2025! Proud of the outstanding #PainResearch presented by my students @reganhines18 and @osullivanduffy. If you’re looking for a talented postdoc, @reganhines18 is set to graduate Fall 2026—reach out!
1
4
228
Come check out the latest work from @reganhines18 and @osullivanduffy on mPFC and BLA circuits/ephys/pharmacology in SNI and CFA pain! See everyone in San Diego @SfNtweets #SfN2025 #Neuroscience #PainResearch
1
4
198
Great lab representation at the @IUStark_Neuro Summer Symposium. @reganhines18 (poster), @osullivanduffy (platform presentation) and our fantastic @NotreDame summer undergraduate Abbie Uche-Ejekwu (poster).
1
1
6
233
Post-qualifying exam lab lunch celebration for official PhD candidate @osullivanduffy. Congrats! Now the real work begins.....
5
179
I was told "Our tech is scheduled to arrive between 8AM-12PM", so I went ahead and scheduled my dentist appointment for 8AM.
147
Very proud of the lab's talented @IUSM_PharmTox graduate student @reganhines18 for winning the @IUStark_Neuro Women in Neuroscience Research & Career Development Award. Anyone looking for a post-doc in ~ 2 years is lucky.
2
2
22
1,195
Do better @DFWAirport. Landed with 95 minutes before connecting flight to Indianapolis. Customs and security took 85 minutes. TSA precheck closed, two security lanes open. Missed connection. Pathetic.
1
1
281
Pass quals ✔️. Present poster at @IASPpain World Congress ✔️. Quite a week for @IUSM_PharmTox @NeurosciStark PhD candidate @reganhines18. #WC2024
2
3
36
1,854
Great presentation by my @IUSMPharmTox student @reganhines18 at the @NeurosciStark Summer Symposium. Please swing by her poster at @IASPpain World Congress.
2
16
592
Frank Porreca and @bannister_lab know how to throw a @PainMechanisms conference. Honored to be a part of it. World-class science, tremendous people. Thanks to Jing Wang @nyulangone for putting together a great Cortical circuits a d pain session.
2
2
20
1,299
Patrick L Sheets retweeted
Regan Hines (@reganhines18) in the @SheetsLabIUSM received an American Society of Regional Anesthesia and Pain Medicine Graduate Student Award for her proposal, “Examining Effects of Pain on Sphingosine-1-Phosphate and Neurons.”
2
15
940
Amazing journey and accomplishment for now Dr. @YinYuexi. It's been a privilege being your mentor. Great students always have to leave. Good luck at @McGeheeLab @UChicago. Big shoes to fill for @reganhines18 and @osullivanduffy.
3
1
25
1,073
The Sheets Lab @IUSMPharmTox is excited to welcome talented graduate student Abigail O'Sullivan-Duffy @osullivanduffy to our team. Abby will be deconstructing pain circuits in the mPFC.
3
2
25
1,795
As a naive graduate student 20 years ago learning ephys and ion channel biophysics, I always checked to see what Bill was doing. Glad I had the privilege of meeting him. RIP.
1
520
Electrophysiologist superstitions? My senior graduate student @YinYuexi cannot pull electrodes before prepping acute brain slices. Me: remember to use manners when asking a cell to seal.... Anyone else?
4
2
18
2,784