@ShepardDale profile picture
Dale Shepard MD, PhD @ShepardDale

Director International Programs, Cleveland Clinic Cancer Institute and Co-Director Cleveland Clinic Sarcoma program. My opinions are mine.

Joined December 2013
  • Tweets 5,213
  • Following 1,041
  • Followers 2,832
344 Photos and videos
Dale Shepard MD, PhD retweeted
NEJM
@NEJM
Feb 25
In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: nej.md/3OIQC5P Science behind the Study: Restoring Function to a Variant of p53 in Solid Tumors nej.md/3N0pQW8
Panel A: A figure showing the change in the sum of diameters of the target lesions across tumor types. Panel B: A figure showing the overall duration of treatment and the time to first response observed in 46 patients treated with a dose in the observed efficacious-dose range who had wild-type KRAS.

ALT Panel A: A figure showing the change in the sum of diameters of the target lesions across tumor types. Panel B: A figure showing the overall duration of treatment and the time to first response observed in 46 patients treated with a dose in the observed efficacious-dose range who had wild-type KRAS.

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Significant progress for patients with sarcoma at #ASCO25 with positive results from 3 phase III trials. Pimicotinib for TGCT, anlotinib for STS and catequentinib for LMS. All are TKIs. @CleClinicMD #CleClinicCancer
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Dale Shepard MD, PhD retweeted
Lilyana Angelov, MD@DrLilyAngelov
13 Dec 2024
The 2025 @ClevelandClinic 17th Annual International Symposium on #SBRT & #SRS will be held February 21-23, bringing together world leaders in brain, spine and body-targeted stereotactic radiation modalities and techniques. Register here: ccfcme.org/SBRT
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Dale Shepard MD, PhD retweeted
David Liska@DavidLiskaMD
14 Nov 2024
Replying to @jsommov @BBrajcich @DrMikeValente @CGAIGC @burkegastrodoc @annaspivs @ScottRSteeleMD @PaulEdWise @rhhollis @arikanters @EmreGorgunMD @NMSurgery
4 decades of data from our @ClevelandClinic Jagelman registries showing no improvement in desmoid related deaths. Call to action to work on improving outcomes for our FAP patients with desmoid disease. @DTRFoundation @ShepardDale @jamecancerdoc @AndyLatchford @OmarFaiz_SETOC
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Dale Shepard MD, PhD retweeted
Katie Ryba@KatieRyba
4 Oct 2024
Listen to @CleClinicMD, Cancer Advances’ 200th episode featuring Dr. Greg Videtic! Dr. Videtic joins @ShepardDale to discuss neuroprotection in small-cell lung cancer patients and key findings from the NRG CC003 trial. cle.clinic/4eu45Xn #CleClinicCancer #200thepisode

Neuroprotection in Small Cell Lung Cancer: Insights from the NRG CC003 Trial

Gregory Videtic, MD, Director of the Thoracic Radiation Oncology Program at Cleveland Clinic, joins the 200th episode of the Cancer Advances podcast to talk about neuroprotection in patients with...

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Dale Shepard MD, PhD retweeted
Jame Abraham, MD, FACP@jamecancerdoc
30 Sep 2024
Congratulations to @AllisonM_Winter who is appointed as the Medical Director of @bikeVeloSano @ClevelandClinic @CleClinicMD !!
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Dale Shepard MD, PhD retweeted
Ofer Reizes@oreizes
26 Sep 2024
Honored to join @RobertoVargasMD to discuss our findings on targeting CD55 to combat chemoresistance in #gyncsm on the latest episode of Cancer Advances hosted by @ShepardDale. #CleClinicCancer cle.clinic/3BlCTeN thanks to all our collaborators @CCLRI @ClevelandClinic.

Advancing Ovarian Cancer Treatment with CD55

Listen as Ofer Reizes, PhD and Roberto Vargas, MD, discuss their research on targeting CD55 to combat chemoresistance in ovarian cancer patients.

my.clevelandclinic.org
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Already having fun at the @bikeVeloSano Kickoff Party promoting #VeloSano and Bike to Cure weekend with @_StephanieHaney and @wkyc
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Dale Shepard MD, PhD retweeted
HemOnc Today@HemOncToday
30 Aug 2024
Use of pembrolizumab with radiation therapy and surgery improved outcomes for certain patients with soft tissue sarcoma. Read the full story, plus expert perspective from @ShepardDale @CleClinicMD @Merck #Keytruda #immunotherapy healio.com/news/hematology-o…

‘Most important study’ in soft tissue sarcomas in decades shows benefit of immunotherapy

CHICAGO — The addition of immunotherapy to radiation therapy and surgery significantly extended DFS for certain patients with soft tissue sarcoma, according to results of a randomized phase 2...

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Dale Shepard MD, PhD retweeted
Jame Abraham, MD, FACP@jamecancerdoc
28 Aug 2024
Appreciate the hospitality by the Vinmec Cancer Team in Hanoi, Vietnam! Looking forward to our continued partnership in cancer care ⁦@CleClinicMD⁩ ⁦@ClevelandClinic⁩ ⁦@DrJohnSuh⁩ ⁦@LShoemakerDO⁩ ⁦@ShepardDale⁩ !
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Dale Shepard MD, PhD retweeted
Katie Ryba@KatieRyba
23 Aug 2024
On the @CleClinicMD, Cancer Advances podcast this week, Dr. Lily Wang joins @ShepardDale to discuss how targeting VISTA & LRIG1 interactions could revolutionize treatment for resistant tumors. #Immunotherapy #CleClinicCancer cle.clinic/4dSsk0C

Exploring VISTA and LRIG1 Interactions: Cancer Immunotherapy

Lily Wang, PhD, from the Department of Translational Hematology Oncology Research at Cleveland Clinic, joins the Cancer Advances Podcast to dive into her research on VISTA and LRIG1 interactions.

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Dale Shepard MD, PhD retweeted
Jame Abraham, MD, FACP@jamecancerdoc
21 Aug 2024
Congratulations @ShepardDale and thank you for your dedication to educating doctors and public about cancer @ClevelandClinic @CleClinicMD !!
Nicole Marie@italgal22
21 Aug 2024
This morning we celebrated our 200th episode of the @CleClinicMD Cancer Advances podcast. Special thanks to our amazing host @ShepardDale editor Bill and my amazing colleague @KatieRyba who runs the podcast like a well oiled machine! #clecliniccancer
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Dale Shepard MD, PhD retweeted
Nicole Marie@italgal22
8 Aug 2024
Replying to @LukasDelasos
@LukasDelasos joins @ShepardDale on Cancer Advances #podcast this week to discuss exciting advancements in #SCLC treatment. Listen as they discuss ongoing research & clinical trials to find better ways to manage this aggressive cancer. #CleClinicCancer cle.clinic/3YxvAtW

Innovations in Small Cell Lung Cancer: ADRIATIC Study

Lukas Delasos, DO, Medical Oncologist at Cleveland Clinic, joins the Cancer Advances podcast to talk about the ADRIATRIC study.

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Honored to represent @bikeVeloSano and throw a first pitch last night at the @CleGuardians game! It was a great experience! VeloSano supports cancer research @ClevelandClinic. Visit velosano.org to learn more.
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Dale Shepard MD, PhD retweeted
Jame Abraham, MD, FACP@jamecancerdoc
30 Jun 2024
Please support #CancerResearch @ClevelandClinic @bikeVeloSano !
ClevelandClinicNews@CleClinicNews
27 Jun 2024
These are stories written by @bikevelosano Bike to Cure participants whose lives have been impacted by cancer. We envision a future with new stories of cures, better treatments, and lives well-lived. To get involved ➡️ velosano.org #togethertocure
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Dale Shepard MD, PhD retweeted
Thejus Jayakrishnan@ThejusJay
17 May 2024
Dr. Khorana discusses research exploring microbiome alterations in individuals with young or early-onset colorectal cancer @aakonc @ShepardDale #microbiome my.clevelandclinic.org/podca… via @clevelandclinic

Exploring the Microbiome in Young-Onset Colorectal Cancer

Listen as Dr. Khorana highlights his research on the link between changes in the microbiome and the development and progression of colorectal cancer in younger patients.

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Dale Shepard MD, PhD retweeted
Katie Ryba@KatieRyba
16 May 2024
Check out our new Cancer Advances podcast with @aakonc, as he talks about his research on how the changes in the microbiome are shown to be linked to the development and progression of #colorectalcancer in younger patients. #CleClinicCancer my.clevelandclinic.org/podca…

Exploring the Microbiome in Young-Onset Colorectal Cancer

Listen as Dr. Khorana highlights his research on the link between changes in the microbiome and the development and progression of colorectal cancer in younger patients.

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Dale Shepard MD, PhD retweeted
Nicole Marie@italgal22
28 Mar 2024
Listen to this week's episode of Cancer Advances with Alison Ibsen, Senior Director for Cancer Programming, who discusses with @ShepardDale the importance of collaboration across departments to create effective care pathways. #CleClinicCancer cle.clinic/4cydnky

Enhancing Patient Care with Cancer Programming

Alison Ibsen, Senior Director for Cancer Programming, joins the Cancer Advances Podcast to talk about the role of cancer programming to enhance cancer patient care.

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Dale Shepard MD, PhD retweeted
Katie Ryba@KatieRyba
21 Mar 2024
Tune into this week's episode of the @CleClinicMD, Cancer Advances podcast during #ColorectalCancerAwarenessMonth with @ShepardDale & @DrMikeValente as they highlight the significant improvements in outcomes for stage 4 colon cancer. #CleClinicCancer cle.clinic/3Vw7Jcv
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Dale Shepard MD, PhD retweeted
Katie Ryba@KatieRyba
14 Mar 2024
On the Cancer Advances podcast this week, @ShepardDale, @FAucejo, and @DrEstfan discuss using ctDNA screening for #colorectalcancer with liver metastases and how this testing can guide treatment decisions & monitor disease progression. #CleClinicCancer cle.clinic/4a85u38

Colorectal Cancer Liver Metastasis

Tune in to learn about the current state of disease management and the potential of ctDNA testing to guide treatment decisions and monitor disease progression.

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