Pathologist, PGY 3 2
Joined March 2021
- Tweets 257
- Following 219
- Followers 145
- Likes 953
11 Photos and videos
Sherrin Jacob retweeted
How long have we known about glomeruli? Today’s teaching point is offered in honor of Marcello Malpighi (1628-1694), the Italian anatomist who is credited with having published the world’s first accurate description of glomerular structure (Bologna, Italy 1666). We learn from those who teach us!
Bellomo G. A short history of 'glomerulus'. Clin Kidney J. 2013 Apr;6(2):250-1. PMID: 26019863
Fogazzi GB. The description of the renal glomeruli by Marcello Malpighi. Nephrol Dial Transplant. 1997 Oct;12(10):2191-2. PMID: 9351094.
Image Credit (for oil painting, Malpighi): Wellcome Collection (wellcomecollection.org/)
#TeachingPoints #kidneypath #renal #pathology
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Sherrin Jacob retweeted
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Sherrin Jacob retweeted
Palate. What is your diagnosis? 🔎
Poll below 🗳️👇
#PathPuzzle 🕵️♂️
@UMichPath #Pathology #PathX #PathTwitter
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Sherrin Jacob retweeted
New #OpenAccess review by N. Paul Ohori MD of @UPMCPathology et al details the fascinating history of PTC nuclei & summarizes the major events representing the paradigm shifts, classification system changes, and controversies: acsjournals.onlinelibrary.wi… #CytoPath #ENTPath
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Apr 26
A quick glance through confusion
Apr 24
#PathQuiz 🔬🦴 #BonePath
10-year-old boy presents with anterior tibial bowing.
A) Fibrous Dysplasia
B) Low-grade central osteosarcoma
C) Adamantinoma of long bones
D) Osteofibrous Dysplasia
#Pathology #BonePath
ALT Woven bone with prominent osteoblastic rimming surrounded by spindle-shaped cells @IARCWHO
ALT Axial CT showing the tumor is confined to the cortex without medullary involvement @IARCWHO
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Sherrin Jacob retweeted
A good 🔬clue to distinguish between mucocele-like lesion (MLL) vs. mucinous carcinoma is the frequent presence of neovascularization in the latter.
Dr. Nour Seige, challenges in breast pathology, Romanian National Congress of Anatomical and Molecular Pathology, First Edition, Bucharest, Romania
#breastpath #PathTwitter
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Feb 14
Ever increasing spectrum of MUC4 positive lesions
Feb 13
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Sherrin Jacob retweeted
Jan 25
Metastases to Small Intestine
- Colonize surface mucosa, creating the impression of a "precursor"
- Asynchronous architecture and cytology
- Patchy surface involvement
- Predominantly intravascular distribution
Uterine (endometrioid) carcinoma metastatic to small intestine (pic 2)
Prostate cancer metastatic to small intestine (pics 3-4)
Always check history if available
Dr. Panarelli - 2025 Diagnostic Pathology Update #USCAP #PathX #PathTwitter
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Sherrin Jacob retweeted
Jan 2
adult human presents with perinephric mass, excised
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Hands down; an important bookmark! 2026 seems to be on fire!
28 Dec 2025
I'm working on a teaching presentation on Hodgkin's lymphoma.
Picture below contains HRS-like cells from 9 different cases.
Which ones are classical Hodgkin's lymphoma and which ones are something else?
#hemepath #pathtwitter #pathology
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If your new year resolution was to exercise, here’s a workout for the pathology brains!! Happy new year everyone!! ✨
Jan 1
Happy New Year to everyone! First case of 2026.
Female in her 50s. Multiple mixed sclerotic and lytic lesions involving the thoracic spine and pelvis.
#PathX #PathTwitter #BSTPath
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Sherrin Jacob retweeted
29 Dec 2025
New in #HumPathol: Colloid cysts of the third ventricle show consistent expression of PAX8 but lack other features of thyroid, müllerian or intestinal differentiation. sciencedirect.com/science/ar… #pathology #PathTwitter #PathX #neuropath
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Sherrin Jacob retweeted
27 Dec 2025
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7 Dec 2025
A wonderful tweetorial to cover the bases. #PathX #PathTwitter
6 Dec 2025
The Epigenetic Engines of Cancer: Decoding the SWI/SNF Complex 🧬⚙️
From the brain (AT/RT) to the lung (SMARCA4-def) to the kidney (MRT). Different organs. Different ages. Same Molecular Culprit.
Why does the loss of one "Chromatin Remodeler" create the most aggressive, chemo-resistant tumors?
A Mega-Thread on SWI/SNF, SMARCA4, & INI1. 🧵👇
#PathX #PathTwitter #MedEd #Oncology
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17 Nov 2025
Too good compilation. #Tweetorial.
16 Nov 2025
1/23 Adult male. Clivus lesion. #PathX #PathTwitter #PathClassic #BSTPath #NeuroPath
#PathClassic followed by #PathTweetorial, with a compilation of cases from #PathX #PathTwitter by colleagues
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16 Nov 2025
Brain teaser!
14 Nov 2025
Middle-aged patient with a mass in a cervical vertebra. There is a hx of sarcoma.
This was not my own case, but I was fortunate enough to see it and learn from it, hence the reason I'm sharing.
Morphology is 🔑
#IHCPath provided is PCK.
What's your diagnosis?
#PathTwitter
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Sherrin Jacob retweeted
12 Nov 2025
Juvenile hyaline fibromatosis/ hyaline fibromatosis syndrome
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Sherrin Jacob retweeted
9 Nov 2025
That’s a great question—and it comes up ALL the time.
Usually—HepPar1-positivity in an adenocarcinoma is evidence of “small intestinal enterocyte” differentiation.
People usually jump to equating it with “hepatoid adenocarcinoma” but it almost never is (1/2)
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