We develop technologies @harvardmed that combine #stem_cell biology, #CRISPR_Cas9 genome editing screens, and #computational_biology to understand gene function
Joined March 2020
- Tweets 136
- Following 1,329
- Followers 901
- Likes 67
21 Photos and videos
Pinned Tweet
23 Dec 2024
(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.1101/…
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23 Dec 2024
(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.1101/…
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23 Dec 2024
(7/8) In sum, ACCESS-ATAC improves the resolution of ATAC-seq and opens up a new ability to analyze single-allele TF co-occupancy. Want to try it? Reach out-- we have built flexible experimental and computational workflows and would be happy to share reagents and expertise!
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23 Dec 2024
(8/8) Plus we’re not the only ones who have realized the power of Ddd enzymes in chromatin analysis: check out the work from @brian_b_liau and colleagues combining DddA and CRISPR to dissect how sequence impacts chromatin state: biorxiv.org/cgi/content/shor…
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Sherwood Lab retweeted
16 May 2024
‼️⚠️Registration Deadline TODAY!⚠️‼️
Register now for the 'From Genetic Discoveries to Gene Function in Human Diseases' Conference to secure your slot and join us in Portugal from 13 - 16 July 2024 #GWAS24☀️🏌️
🔗➡️bit.ly/4bnHuu6
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24 Apr 2024
We are very happy to see that our manuscript, 'Joint Genotypic and Phenotypic Outcome Modeling Improves Base Editing Variant Effect Quantification,' is now published in @NatureGenet . Congratulations @JayoungR
26 Sep 2023
Absolutely thrilled to share this incredible work led by @JayoungR ! A huge shoutout to the collaborative efforts with @SherwoodLab, @ccassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint!#CRISPR #BEAN 🧬🌟☕️
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Sherwood Lab retweeted
26 Sep 2023
Excited to share our work introducing BEAN🫘, a pipeline that greatly improves the power of CRISPR base editing screens🚀!
BEAN utilizes surrogate per-gRNA editing outcomes, identifying coding & noncoding variants impacting LDL cholesterol uptake.
📰medrxiv.org/content/10.1101/… (1/)
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Sherwood Lab retweeted
26 Sep 2023
Absolutely thrilled to share this incredible work led by @JayoungR ! A huge shoutout to the collaborative efforts with @SherwoodLab, @ccassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint!#CRISPR #BEAN 🧬🌟☕️
26 Sep 2023
Excited to share our work introducing BEAN🫘, a pipeline that greatly improves the power of CRISPR base editing screens🚀!
BEAN utilizes surrogate per-gRNA editing outcomes, identifying coding & noncoding variants impacting LDL cholesterol uptake.
📰medrxiv.org/content/10.1101/… (1/)
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Sherwood Lab retweeted
13 Jun 2023
I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews authors.elsevier.com/a/1h8Og… 🧵
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21 Apr 2023
We are excited to share our latest publication in @CellGenomics by @miahamilton5 et al.
cell.com/cell-genomics/fullt…
#Genetics #CRISPR #tweetorial
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21 Apr 2023
We are excited to apply our pipeline to get to the bottom of the genetics of lipids and cardiovascular disease risk, unraveling new cellular mechanisms beyond LDL uptake and pinpointing genetic variant effects using more precise CRISPR tools. 15/16
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21 Apr 2023
A huge thank you to everyone that contributed to this project since we started it way back in pre-COVID times! @miahamilton5 @minja_bio @ccassa @akinci_ersin @Glettre @3xon5kip and all the members of @sherwoodlab Check out our full manuscript at cell.com/cell-genomics/fullt… 16/16
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