We focus on the molecular biology of cancer using CRISPR gene editing technology, as well as the development of new editors for the CRISPR screening toolbox.

Joined November 2017
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Pinned Tweet
We are thrilled to share our latest publication at @MolecularCell about a multiple PTM reader ZMYND8 in regulating an AML-specific TF circuit! authors.elsevier.com/c/1dX3Z…

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We are thrilled to share our latest publication at @MolecularCell about a multiple PTM reader ZMYND8 in regulating an AML-specific TF circuit! authors.elsevier.com/c/1dX3Z…

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Our study rationales ZMYND8 as a promising therapeutic target in AML.
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Tremendous efforts have been made by our spectacular lab mates as well as collaborators. We also received supports from the Linda Pechenik Montague Investigator Award and CSHL-sponsored research. Many thanks!!
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Shi Lab @ UPenn retweeted
1 Oct 2020
Mark your calendars! The annual Flu Clinic in Bodek Lounge, Houston Hall will take place Oct. 12th-16th. Flu vaccines are free for all students, staff, and faculty. When: Oct. 12th-16th •Mon-Thurs: 10am-4pm •Fri: 10am-2pm campushealth.wellness.upenn.…

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Shi Lab @ UPenn retweeted
The CAMB Symposium is 1 week away! October 2nd, Distinguished CAMB Alum, Jeannie Lee, MD, PhD (Harvard Genetics) will present the Keynote Lecture on "Choosing sides: X-chromosome inactivation, CTCF, and Polycomb"
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Another robust study out from the Berger Lab!
28 Sep 2020
Check out our latest work on epigenetic alterations in Alzheimer's disease by @NativioR, out now in @NatureGenet. A fantastic, multi-omic, collaborative effort utilizing human tissues and fruit fly models rdcu.be/b7N8W @PennEpiInst @PennCDB @PennGenetics @PennBiology
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Shi Lab @ UPenn retweeted
Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer (Gao et al.) go.nature.com/2QBocJU
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Shi Lab @ UPenn retweeted
NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing (Shirane et al.) go.nature.com/3mniY2Q
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We are excited to welcome our new postdoc, @HappyPing5, to the lab! Ping is interested in applying single cell-omics to investigate regulatory networks in exhausted T-cells. Ping will also be working in the @WherryLab. Welcome Ping!
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We couldn't be more proud of our graduate student @nhevitt for receiving an F30 award today! Congrats Nik!!!
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We are thrilled to welcome @BMBGGUPENN graduate student @biancapingul into our lab for her thesis work!!! 🧪🧬🔬
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Congratulations @QiQiu8788!!!
We made a mistake! Our original "postdoctoral" recipient was, in fact, a graduate student but we are pleased to recognize both @jloops22 and @EduardoATorre with the predoctoral award. Congratulations to @QiQiu8788 for receiving the postdoctoral award!
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Shi Lab @ UPenn retweeted
We made a mistake! Our original "postdoctoral" recipient was, in fact, a graduate student but we are pleased to recognize both @jloops22 and @EduardoATorre with the predoctoral award. Congratulations to @QiQiu8788 for receiving the postdoctoral award!
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A big congratulations to @EduardoATorre ! Well deserved recognition for your work!
We made a mistake! Our original "postdoctoral" recipient was, in fact, a graduate student but we are pleased to recognize both @jloops22 and @EduardoATorre with the predoctoral award. Congratulations to @QiQiu8788 for receiving the postdoctoral award!
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