We find out where RNA modifications are, what they do, how they do it and why that matters
Joined May 2019
- Tweets 841
- Following 465
- Followers 477
- Likes 3,136
48 Photos and videos
Pinned Tweet
May 13
Thanks to @NatRevMCB for inviting me to highlight the paper that brought us direct-RNA-seq. It has been exciting using "my precious" nanopore to map RNA modifications.
New Online! RNA modifications: one ring to map them all dlvr.it/TSVjjX
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Sho Goh Lab retweeted
Jun 12
I enjoy using IGV, but I need a more efficient tool for analyzing diploid genomes. So, I developed one for myself. It provides exceptional GPU acceleration, allowing me to uncover all essential information spanning six orders of magnitude. #bioinformatics #genomics #visualization
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Jun 4
Quite an innovative question
1/n What fraction of the human genome is essential for cellular viability?
Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads.
@sudpinglay @JShendure
biorxiv.org/content/10.64898…
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Jun 1
This is why we need biomedical research
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM
@ASCO
ALT Graph from a study published in the New England Journal of Medicine on daraxonrasib versus chemotherapy for metastatic pancreatic cancer. The x-axis represents months, and the y-axis shows the percentage of patients alive. Two lines indicate survival rates: daraxonrasib (blue) and chemotherapy (gray). The bottom section lists patients at risk over time. Title and journal logo are included.
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Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM
@ASCO
ALT Graph from a study published in the New England Journal of Medicine on daraxonrasib versus chemotherapy for metastatic pancreatic cancer. The x-axis represents months, and the y-axis shows the percentage of patients alive. Two lines indicate survival rates: daraxonrasib (blue) and chemotherapy (gray). The bottom section lists patients at risk over time. Title and journal logo are included.
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May 31
I... this is... wait what?
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Sho Goh Lab retweeted
May 15
Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. nature.com/articles/s41587-0…
12 Nov 2025
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our @MicahGoldrich and Louis Delhaye from @pieter_mestdagh. TL;DR we show that many of lncRNA chromatin occupancy maps are flawed🧵biorxiv.org/content/10.1101/…
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Sho Goh Lab retweeted
Probably Craig Venters last interview.
The people who drone on about the necessity of NIH “basic science” are the duds and dropouts of the class.
It’s food stamps for the underachievers.
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Sho Goh Lab retweeted
Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics go.nature.com/4tjA7MI
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Sho Goh Lab retweeted
omg this title, this paper
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15 Nov 2025
You are my AI hero. However, I disagree about biology. At this moment, we need more high-quality data, the proper measures, and relevant questions. I actually wrote about this earlier today x.com/msikic/status/19895770…
15 Nov 2025
Saturday mornings are ideal for contemplating AI in biology. It’s one of the most important frontiers for AI—but we can’t just copy what works for text or images. Biology speaks a different language. Right now, two major directions are emerging... 1/6
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14 Nov 2025
Our new discovery that bacteria utilize extracellular vesicles to deliver RNAs into fungi substantially broadens the paradigm of Cross-Kingdom RNA communication! Big congrats to @J_NinoSanchez, @HuaitongW and all! Thanks for your hard work! cell.com/molecular-plant/abs…
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5 Nov 2025
Just finished giving the last talk at this amazing Asian RNA Club Symposium that was full of other talks and posters with new unpublished stories. Looking forward to the next Symposium in 2 years at Nara, Japan!
3 Nov 2025
アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！
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Sho Goh Lab retweeted
3 Nov 2025
アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！
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24 Oct 2025
I was amazed by this tour de force to profile 16 different RNA modifications simultaneously when i first heard @SchragaSchwartz talk about it. I'm still amazed now.
cell.com/cell/abstract/S0092…
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2 Sep 2025
Always great to have old friends visit us in SZ. Today, fellow HannonLab alumnus @Elvin_Wag from @IcahnMountSinai visited us at @ShenzhenBayLab to share his experience researching cancer stem cells, give career advice to our young scientists and enjoy our famous roast pigeon
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22 Aug 2025
Why is it suddenly so difficult to buy phase-lock tubes? Anyone knows anyone who's still selling?
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22 Aug 2025
Always been interested in the possible roles of RNA mods outside of the full-length RNA they are derived from. Following their earlier work of m6A nucleosides as receptor ligands, Ogawa et al identify how modified nucleosides can also cause toxicity
cell.com/cell/fulltext/S0092…
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