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Simon Fandler-Höfler @SimonFaHo

Neurologist focussing on intracerebral haemorrhage, stroke and neurological emergency medicine @MedUniGraz, Austria and @UCLStrokeRes

Joined June 2023
  • Tweets 82
  • Following 131
  • Followers 189
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Simon Fandler-Höfler@SimonFaHo
3 Nov 2024
(1/3) In which patients with intracerebral hemorrhage should advanced work-up such as digital subtraction angiography be performed? The MACRO score may help - using a few simple MRI parameters it allows to reliably assess the risk of macrovascular causes: neurology.org/doi/10.1212/WN…

MRI-Based Prediction of Macrovascular Causes of Intracerebral Hemorrhage | Neurology

Background and ObjectivesAlthough most spontaneous intracerebral hemorrhages (ICHs) are due to cerebral small vessel diseases (SVDs), between 1 in 7 and 1 in 10 are due to a macrovascular cause....

neurology.org
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Simon Fandler-Höfler retweeted
Amy Nelson@amypknelson
Feb 12
New paper out today - 8 years of work! Prehospital emergency anaesthesia with intubation improves survival by 10.3% in high risk major trauma. Not only life-saving, it is so cost effective (£100m in DALYs/UK/year) it justifies NHS funding of air ambulances thelancet.com/journals/lanre…

Survival effect of prehospital emergency anaesthesia with intubation in risk-stratified patients...

Guiding prehospital intubation by a machine-learning stratification model of prehospital data is predicted to improve 30-day survival of major trauma patients. This is, to our knowledge, the highest...

thelancet.com
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Should patients with AF and history of ICH be treated with oral anticoagulation? A subanalysis of PRESTIGE-AF underlines individualised decisions (based on neuroimaging) - particular risk of recurrent ICH when cortical superficial siderosis and chronic ICH on MRI are present.
Neurology Journal@GreenJournal
27 Nov 2025
In this study the authors assessed the role of neuroimaging in identifying patients with particular susceptibility to #IschemicStroke or intracerebral hemorrhage, with the potential to enable individualized risk stratification: hubs.la/Q03V_lDq0 #NeuroTwitter @SimonFaHo
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On the other hand, patients with non-lobar ICH had a higher risk of recurrent ischaemic stroke — possibly due to multiple concurrent stroke mechanisms (AF small vessel disease). Major limitations: modest sample size, few outcome events. Larger meta-analyses needed.
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1/3 Should patients with AF and history of intracerebral haemorrhage treated with oral anticoagulation? This subanalysis of PRESTIGE-AF provides new data, indicating that individualised decisions based on neuroimaging ( clinical profiles) might be prudent: neurology.org/doi/10.1212/WN…

Neuroimaging Markers Associated With Recurrent Stroke in Intracerebral Hemorrhage and Atrial...

Background and ObjectivesAnticoagulation in patients with intracerebral hemorrhage (ICH) and atrial fibrillation reduces the risk of ischemic stroke (IS), but also potentially causes an excess risk...

neurology.org
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2/3 In this RCT (n=313) randomising patients with AF and prior ICH to anticoagulation vs not, cortical superficial siderosis and chronic intracerebral macrohaemorrhages on MRI strongly predicted recurrent ICH — potentially identifying patients at excess bleeding risk from OAC.
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3/3 On the other hand, patients with non-lobar ICH had a higher risk of recurrent ischaemic stroke — possibly due to multiple concurrent stroke mechanisms (AF small vessel disease). Major limitations: modest sample size, few outcome events. Larger meta-analyses needed.
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Simon Fandler-Höfler retweeted
International Journal of Stroke
@IntJStroke
18 Jul 2025
#FlashbackFriday ! 🌍🧠World Stroke Organization (WSO): Global intracerebral hemorrhage factsheet 2025 journals.sagepub.com/doi/ful… @adrianpj1 @WorldStrokeOrg @WorldStrokeEd
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Simon Fandler-Höfler retweeted
International Journal of Stroke
@IntJStroke
15 Jul 2025
🧠Study of long-term outcome in young patients after ischemic stroke or TIA ⬆️Women had higher risk of post-stroke depression, anxiety & fatigue 🫀🚭Hypertension & smoking were modifiable risk factors contributing to worse outcome Read more here!👇 journals.sagepub.com/doi/abs…

Long-term outcome of young patients after ischemic stroke or transient ischemic attack: Insights...

Background: The long-term non-motor outcome of young adults with ischemic stroke (IS) or transient ischemic attack (TIA) is poorly understood. Aims: Therefore,...

journals.sagepub.com
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Simon Fandler-Höfler retweeted
Stephan A Mayer
@stephanamayer
2 Jul 2025
This is a breakthrough study that forges a new future — POC biomarkers for identifying #ICH in the prehospital phase. Rapid Diagnosis of ICH with GFAP Levels on a Point-of-Care Device (DETECT) @neurology #curingcoma neurology.org/doi/10.1212/WN…

Rapid Diagnosis of Intracerebral Hemorrhage in Patients With Acute Stroke by Measuring Prehospital...

Background and ObjectivesThe rapid identification of intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke is decisive for prehospital triage and initiation of targeted therapies....

neurology.org
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Simon Fandler-Höfler retweeted
Stroke AHA/ASA@StrokeAHA_ASA
21 Apr 2025
#STROKE: In patients with acute ischemic stroke, admission NT-proBNP may predict the in-hospital development of atrial fibrillation detected after stroke (AFDAS), and a threshold of 505 pg/ml confers good discriminatory value. #AHAJournals ahajournals.org/doi/10.1161/…
Graphic abstract in Hatab and Kneihsl et al.

ALT Graphic abstract in Hatab and Kneihsl et al.

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Simon Fandler-Höfler retweeted
Stroke Research Center Bern@StrokeBern
4 Apr 2025
How do chronic ischemic lesions differ in patients with #AtrialFibrillation and #SmallVesselDisease? We compared MRIs from @ELAN_Trial and #SVD cohorts: whereas AF patients had mostly cortical cerebellar lesions, SVD patients had deep lesions ahajournals.org/doi/pdf/10.1…
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David Seiffge@DavidSeiffge
3 Mar 2025
EURECA: New data on recurrent ICH: every second recurrence is adjacent to index ICH. Those bleedings occur early and are strongly associated with CAA. Great collaboration lead by @mbgoeldlin @StrokeBern Author interview podcast: edhub.ama-assn.org/jn-learni… jamanetwork.com/journals/jam…

Location and Timing of Recurrent, Nontraumatic Intracerebral Hemorrhage

Interview with David J. Seiffge, MD, author of Location and Timing of Recurrent, Nontraumatic Intracerebral Hemorrhage. Hosted by Cynthia E. Armand, MD.

edhub.ama-assn.org
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Simon Fandler-Höfler retweeted
Gargi Banerjee@DrGargiBanerjee
1 Mar 2025
New in @JNNP_BMJ - the next chapter in the story of iatrogenic CAA 📕 and it really does seem to be different to sporadic CAA. Presence of deep haemorrhagic pathology in particular is unexpected but persistent signal. So what does this mean? … 1/3 🧵 jnnp.bmj.com/content/early/2…

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Hatice Ozkan@HOzkan92
22 Feb 2025
Our meta-analysis of 279 stroke studies over 24 years, with 117K participants, found that 1 in 2 stroke patients experience adverse non-motor outcomes. Adjusted meta-regression shows 8/10 domains persist more than 10-years. Time for change in stroke care. jamanetwork.com/journals/jam…

Patient-Reported Nonmotor Outcomes After Stroke

This systematic review and meta-analysis evaluates the prevalence, natural history, and factors associated with multidomain nonmotor outcome burden in patients with stroke.

jamanetwork.com
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Simon Fandler-Höfler retweeted
UCL Stroke Research@UCLStrokeRes
20 Feb 2025
Check out our latest paper providing the most comprehensive description of the phenotype and natural history of iatrogenic Cerebral #Amyloid Angiopathy. A great international collaboration thanks to @SimonFaHo @DrGargiBanerjee @KKaushikMD @LVpanteleenko and many others!
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1/4 Iatrogenic cerebral amyloid angiopathy (iCAA) is a scary rare disease affecting patients 30-50 years after possible CNS exposure to pathological amyloid-beta. In a large international collaboration, we investigated neuroimaging findings and clinical outcomes in 51 patients.
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3/4 Besides severe CAA on MRI, we found: a) major progression of CAA markers over 4 years b) ipsilateral-dominant spread of haemorrhagic lesions (from amyloid-beta exposure) c) frequent deep microbleeds d) frequent inflammatory changes e) very frequent small intragyral ICH
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4/4 This indicates that patients with iCAA appear to have distinctive MRI characteristics, which might differentiate iCAA from other CAA subtypes and provide new insights into disease mechanisms. jnnp.bmj.com/content/early/2… @DrGargiBanerjee @UCLStrokeRes @BenStorti @KKaushikMD
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Simon Fandler-Höfler retweeted
Neurology Journal@GreenJournal
11 Feb 2025
This case highlights the diagnostic approach and importance of thorough clinical evaluation of young patients with intracerebral hemorrhages. hubs.la/Q035vSv10 #NeurologyRF #NeuroTwitter
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