Joined May 2021
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Just released a snapshot investment report on @eXoZymes $EXOZ 🔬🧪💊 It covers the latest key developments and a speculative roadmap with market cap projections until 2028 slack-capital.com/p/exozymes… If you missed my inital report, this post offers a fantastic investment intro

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James - Slack Capital retweeted
A defining milestone for $IVZ and the Cabora Bassa Project, with the PPSA now executed with the Republic of Zimbabwe, establishing a clear framework for long-term development. With this in place, focus now moves to the Musuma-1 exploration well, targeting spud in H2 2026. #PPSA
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Whether you call it a 'Pick and Shovel Play' or a 'Platform of Platforms', @eXoZymes is building one of the most compelling Stacked Valuation Strategies on NASDAQ today Every new compound $EXOZ develops unlocks another independently measurable revenue stream, adding another layer of value to the platform behind it all Instead of a single binary biotech bet, shareholders own a stake in a compounding engine built to generate more value, more upside and more long-term returns with every success With 30 compounds in its Idea Management System, the runway ahead is enormous
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The next major catalyst for $EXOZ is its NCT human-use studies Positive indications won't just validate a single product, they will reveal the true extent of @eXoZymes near-term investment opportunity Preclinical NCT mouse models have already shown impressive effects on liver fat, mitochondrial function and metabolic health, including a 30% reduction in body weight With @eXoZymes' demonstrated ability to produce <99% pharmaceutical grade NCT, translation of prior mouse studies into humans would provide decisive validation for: → NCT as a world-class compound entering a 100B metabolic health and longevity wellness market → NCTx, the company's spin‑out entity, which holds the commercial rights and is driving near-term OTC revenues → eXoZymes' NCT Pharma Analog program, which is developing more potent, patent-protected drug candidates for some of the world's most valuable disease markets With human use studies currently underway, the market could receive its answers as soon as Q3 2026 If the human data confirms what preclinical work has already suggested, investors won't just be looking at another "milestone"... they'll be looking at a major re‑rating in $EXOZ shares
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While @exozymes’ NCT and cannabinoid-like programs are likely to become standalone multi-billion dollar opportunities, their commercial launch ultimately serves a greater purpose... validating the company's cell-free biomanufacturing platform This is just the first turn of eXoZymes’ flywheel engine! Most biotech companies are built around a single asset, where success or failure depends on a binary outcome. @eXoZymes is different... the company is designed to repeatedly create, validate and scale high-value compounds across nutraceuticals, pharmaceuticals and beyond eXoZymes' flywheel works like this: → Each compound validates the platform's capabilities → Validation attracts partners and licensing deals → Each new deal expands the revenue base → Revenue accelerates future compound launches Already, @eXoZymes has 30 high-impact compounds in its pipeline and is seeing growing interest from pharmaceutical partners With the two initial programs targeting a combined TAM of $200B, these are not isolated opportunities... they represent the first turns of a continuous flywheel, compounding value back to $EXOZ shareholders
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James - Slack Capital retweeted
In this episode, Tyler Korman, Chief Scientific Officer and Co-Founder of eXoZymes, explains how AI-enhanced, cell-free enzyme technology could transform the future. 🎶tinyurl.com/2tb2s9zr LinkedIn: linkedin.com/in/tyler-korman… #Exozymes #Biomanufacturing #SyntheticBiology
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James - Slack Capital retweeted
In this episode of Healthcare Happenings, @eXoZymes (Nasdaq: $EXOZ) CEO Michael Heltzen joins Tim Gerdeman and Robert Sassoon to discuss the company’s AI-driven, cell-free biomanufacturing platform. 🔹 Technology focus. “Exozyme” approach aims to address scalability challenges in synthetic biology. 🔹 Commercial strategy. Advancing programs in metabolic health and non-intoxicating cannabinoids. 🔹 Platform potential. Enables production of high-value molecules that have been difficult to scale historically. 🔹 Path forward. Focus on near-term milestones, regulatory dynamics, and a dual strategy of internal development and future licensing. Listen to the full episode for additional insights into ExoZymes’ technology and growth strategy. Podcast Platforms: pod.link/1795488592 Website: watertowerresearch.com/media… $EXOZ #Biotech #SyntheticBiology #AI #HealthcareInnovation #Biomanufacturing #Investing #SmallCaps #WaterTowerResearch
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Nearly a year ago, @eXoZymes introduced NCTx to the world at the @SynBioBeta conference. Could we see another big announcement at this year's event? Soon after, $EXOZ will have their Q1 Investor Call, so there's plenty to look forward to! đź‘€
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Looking forward to @eXoZymes NCTx's Human Use Studies this QUARTER & their Pharmaceutical Analogues preclinical program in H2 2026 If the science proves out, the opportunity here is massive. 1.4 billion people worldwide are affected by obesity, diabetes & metabolic dysfunction
From The @villagevoice: The Metabolic Engine - How Scientists Are Exploring a New Path Beyond GLP-1 Weight-Loss Drugs America’s weight-loss conversation has changed almost overnight. Prescription drugs once reserved for diabetes treatment are now household names, promising dramatic results on the scale. Many therapies currently available focus on reducing appetite or limiting calorie intake, which can certainly lead to weight loss. Yet those solutions often address the symptom rather than the deeper metabolic engine driving the condition. Interest is growing around strategies that target the body’s internal energy system itself. Instead of simply telling the body to eat less, researchers are investigating ways to improve how the body burns energy, processes fat, and maintains metabolic balance. That shift in thinking has opened the door to a small but intriguing molecule known as N-trans-Caffeoyltyramine, or NCT. Full story available here: na2.hubs.ly/H04N4_c0
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The shift in @eXoZymes underlying narrative is undeniable... the technology is delivering unprecedented results and the commercial opportunity is becoming impossible to ignore An incredibly exciting period ahead for the company, investors and the future of biomanufacturing!
CCO at @eXoZymes, Damien Perriman, interviewed at @Nasdaq around our NCT project: "We’ve shown that we can go from idea to 100× pilot scale in 12 months - and hit it right the first time. That kind of speed and predictability is exactly what this industry has been missing, and it’s what turns a single success into a repeatable value engine." #exozymes #exozyme #enzymes #enzyme #NCT #Nasdaq #ntranscaffeoyltyramine $EXOZ
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It’s wild how biotech celebrates breakthrough AI drug discoveries yet there’s little discussion about how to actually synthesise these compounds @eXoZymes $EXOZ will deliver that solution and their recent external pilot validation of NCT proves the industry is finally waking up!
Interview: @CaymanChemical validates @eXoZymes' technology and scalability Director of Catalog Chemistry Production at Cayman Chemical, Patrick Westcott, states: “During the experiment, from the first sample that we took the analysis showed over a 99% conversion rate. There was some concern because I thought that that maybe was a little bit too high. So, we decided to take a second sample to see if it maintained a similar conversion rate. And we were a little surprised to find out that we actually did achieve this 99% conversion in our first 100-fold scale up of their process. That was very much an aha moment for us!” See the full interview here: na2.hubs.ly/H04mBkv0 $EXOZ #exozymes #exozyme #enzymes #enzyme #biomanufacturing #CaymanChemical #chemicals #biocatalysis #pilotscale #NCT #Ntranscaffeoyltyramine
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A must watch for those interested in @eXoZymes! Three of the company’s heavy hitters sit down and discuss the events of 2025 as well as the MASSIVE opportunities in 2026 and beyond
It's time for another Heltzen's Video Highlight: 2025 in Review and Looking Ahead! In this video, I'm having conversations with our CSO, Tyler, and our CCO, Damien, about what happened last year and what we anticipate happening this year. Full video available here: na2.hubs.ly/H02S7b90
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Long and painful journey holding @energy_invictus $IVZ.ax however, with the PPSA being signed in January, it finally unlocks multiple catalysts for an exciting 2026! - AMH 19.9% Equity Stake funds - Additional 30.1% Equity Stake funds - Multiple AMOG M&A deals - Musuma-1 Spud
We're pleased to announce the completion of the Petroleum Production Sharing Agreement (PPSA) process for the Cabora Bassa Project in Zimbabwe - establishing a stable and internationally competitive legal and fiscal framework for petroleum operations. 👉 api.investi.com.au/api/annou…
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From @eXoZymes VP of Comms on why the company isn’t already valued in the billions: 'We need the last and most important thing: Commercial scale' They are planning on scaling their technology in July - September next year, one of the final major derisking events for the company
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"Success could mark a new era in biomanufacturing one in which AI-enhanced enzymes enable unlimited access to all of Mother Nature's valuable natural products" New Era of Biomanufacturing! @eXoZymes just achieved 99% conversion yield on its NCT compound ibtimes.com/ai-meets-enzymes…
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Recently, I updated the look of @Slack_Capital to better reflect where the publication stands today compared to where it started. Big thank you to everyone who has subscribed since the launch in February. I’ve loved connecting and discussing various ideas with other investors.
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Another point to consider is that, at its core, eXoZymes’ creates biochemical production solutions for a wide range of compounds. The company has just chosen to initially launch in the nutraceuticals and pharmaceuticals space because these markets are extremely high-value and operate with relatively low product volumes. Unlike industrial chemicals, which they can also serve, but these typically operate on lower margins that require high production volumes. There are many pharmaceutical APIs and natural-compound that show strong promise in the lab but never actually reach commercialisation because they strggle to be manufactured efficiently or economically at scale. eXoZymes’ platform is designed to unlock these types of high-value compounds by creating a viable and scalable production solutions. eXoZymes' NTC compound is a perfect example of what the platform can achieve. I'd say over the next 24 months, eXoZymes will launch its own developed assets via spin-outs and joint ventures. This will allow the company to demonstrate the platforms performance and commercial viability before they shift to technology-licensing agreements. This is also why I said, they'll develop a playbook as there is lots to learn in the rollout. Once eXoZymes reaches the licensing stage, companies will engage them to undertake R&D and design production solutions for specific compounds. Traditionally, in the biotech space this takes years and costs many millions of dollars. By contrast, eXoZymes’ AI-driven process and innovative system, reduces timelines down to mere months and at a fraction of the cost. Under these future licensing partnerships, eXoZymes would receive milestone payments for achieving certain R&D objectives as well as licensing payments tied to the production/sales of that targeted chemical. In the nutraceuticals and pharmaceuticals space, licensing fees typically range 5-10%. If eXoZymes can provide the only scalable or economically viable solution, then they can negotiate from a position of strength. The food flavors, fragrances and industrial chemicals sectors operate on smaller margins but they do have much larger production volumes. Licensing fees here range between 2-5%. eXoZymes operates on a capital-light and low-operational cost model. They will eventually have high profit margins.
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NCT as a supportive supplement to GLP-1s In a pivotal mouse study, NCT given alongside a high-fat diet led to 35-40% less weight gain compared to mice just on a high-fat diet. On its own, NCT doesn't cause rapid weight loss. In another study, obese mice given NCT for 2 weeks saw no drop in body weight however, it did reverse hepatic steatosis (fatty liver). This suggests NCT may help people maintain normal eating patterns without putting on as much weight. For those already obese, GLP-1s could be used for rapid initial weight loss and then NCT could be taken afterwards for maintenance and weight gain prevention. NCT keeps metabolism rates high, effectively fighting the body's natural tendency to slow down metabolism and regain weight. It also helps reverse obesity-related mitochondrial and liver damage. Importantly, it promotes lipophagy, where liver cells break down their own stored fat. A clearer, healthier liver directs incoming calories toward energy production instead of fat storage. Using GLP-1 first and then transitioning to NCT could also reduce the typical long-term issues with GLP-1s, including rapid rebound weight gain, ongoing muscle loss and dependence on continuous injectables. Thoughts @LouBasenese
26 Nov 2025
"There are moments in science when something small and elusive suddenly becomes attainable, when a molecule trapped in the fine print of research papers becomes the centerpiece of an entirely new chapter in health. That is what happened when eXoZymes turned its attention to plant-derived N-trans-caffeoyltyramine (NCT), an investigational compound with the potential to change how the world treats chronic metabolic and inflammatory diseases." “The beauty of leading with NCT,” said Damien Perriman (@Perriman), eXoZymes’ Chief Commercial Officer, “is that we’ve taken something nature only whispers about and figured out how to make it into something we can actually use, because we can provide it at scale.” Full @VanityFair article available here: na2.hubs.ly/H02d-Lq0 #exozymes #exozyme #enzymes #enzyme #nct #nctx #biomanufacturing #biosolutions
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Thanks for the repost of my Substack @eXoZymes! $EXOZ
19 Nov 2025
Quoting @Slack_Capital's latest report: "eXoZymes’ recent Q3 investor call was, in my view, a genuine inflection point for the company. For the first time, management laid out a clear, commercially driven roadmap that connects near-term revenues, potential multi-billion-dollar exits and a disciplined capital and operating strategy designed to protect and compound shareholder value [...] $EXOZ is a once-in-a-lifetime opportunity." Read the full report here: na2.hubs.ly/H026wfQ0 Disclaimer: This content references an independent investment research report prepared and published by a third-party organization, Slack Capital. The views, opinions, estimates, forecasts, and conclusions expressed in the report are solely those of the authors and do not reflect the views or positions of @eXoZymes.
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