Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social
Joined August 2015
- Tweets 13,915
- Following 2,437
- Followers 2,329
- Likes 7,993
338 Photos and videos
Pinned Tweet
6 Nov 2025
🚨Publication alert! Stoked to report the structural basis for activity of a novel class of antimicrobials targeting Gram positive priority pathogens in @NatureComms. There is something for everyone on this paper; highlights 👇 1/9 doi.org/10.1038/s41467-025-6…
1
1
5
405
Jun 12
A family of small proteins links c-di-GMP riboswitch signaling with sporulation in Clostridioides difficile biorxiv.org/content/10.64898… from @JohannPeltier 's lab
143
Jun 10
Acidification-dependent suppression of C. difficile by pathogenic and commensal enterococci | Infection and Immunity journals.asm.org/doi/10.1128… - #butcanitoccurinvivo?
86
Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile onlinelibrary.wiley.com/doi/…
1
105
Wiep Klaas Smits retweeted
Jun 4
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome | Nature nature.com/articles/s41586-0…
5
12
495
Interesting story: from FMT to LBP - 15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial @NatureMedicine nature.com/articles/s41591-0…
2
87
Reminder to my fellow Dutchies and everyone visiting here today to not get a total jumpscare at noon when both the air raid AND NL alert tests go off!
Reminder to fellow Dutchies that the NL alert and air raid test is coming up in 5 minutes to jumpscare the bejeesus out of you. 🙋🏻♀️
1
1
6
1,480
Characterizing the Molecular Determinants of Clamp Binding in B. subtilis biorxiv.org/content/10.64898…
92
May 29
Dynamics in Circulating Immune Cell Subsets After Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection : Clinical and Translational Gastroenterology journals.lww.com/ctg/fulltex…
78
Wiep Klaas Smits retweeted
May 28
Bacteria don't need signaling cascades to rewire gene silencing. They use DNA 🧬 twist.
➕Overwind → H-NS forms a filament.
➖Underwind → H-NS bridges and silences.
📣Topology is the switch.
See our preprint for more details:
doi.org/10.64898/2026.05.23.…
ALT H-NS transition between stiffening and bridging modes dictated by DNA superhelicity
6
34
136
8,042
May 26
Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM - pubmed.ncbi.nlm.nih.gov/4215…
94
May 22
A framework for peptide identification on commercial nanopore sequencing platforms biorxiv.org/content/10.64898…
1
126
May 22
Microbe Decoder uncovers functional traits of microbes in microbiome datasets academic.oup.com/nar/article…
90
May 21
1
62
May 20
Fc-free single-chain antibody mRNA therapy for airway infection of multidrug-resistant Pseudomonas aeruginosa nature.com/articles/s41467-0… - lovely concept!
85
Wiep Klaas Smits retweeted
May 19
Systematic analysis of CHAP domain-containing genes deletion mutants links cell wall architecture to antibiotic susceptibility and pathogenesis in S. aureus ift.tt/VIDts43
1
75
May 19
Epigenetic phase variation in the gut microbiome enhances bacterial adaptation: Cell Host & Microbe cell.com/cell-host-microbe/f…
1
4
368
May 19
Programmable Peptide Nanofibers Enable Effective MRSA Biofilm Eradication and Infection Control | ACS Applied Bio Materials pubs.acs.org/doi/10.1021/acs…
1
131
May 19
Identification of genes involved in extracellular DNA release during biofilm formation in Clostridium perfringens sciencedirect.com/science/ar…
90
May 19
Not just passengers: Phages as agents of genetic exchange in fecal microbiota transplantation sciencedirect.com/science/ar…
1
1
2
234