How to determine the proteome of cellular compartments?
We established a method to do just that, published in @elife: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLife.111393…
What if you could cut out sub cellular structures and measure their proteome?
SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection biorxiv.org/content/10.64898…
awesome work by @CurdinF, @Alexia__F ,@Biehli & Alexander Schmidt
I'm thankful to all our collaborators @Spang_Lab@samit2104, Anne Grahl, @LabStahlberg, Meltem Tatli and Dongchun Ni and my mentor, Stephan Grzesiek, who helped us bring this story to life.
Check out our latest paper! Congrats to Daniel Ott @Samit2104 and Jachen Solinger! well done! Coordination between ESCRT function and Rab conversion during endosome maturation | The EMBO Journal embopress.org/doi/full/10.10…
Congratulations to Anne Spang @Spang_Lab for receiving the renowned Lelio Orci Award. The award honors her pioneering work in intracellular organization and her research achievements in Cell Biology. @LS2Switzerland @UniBasel_enbiozentrum.unibas.ch/news/de…
The newly founded study group on Cellular Organelles of the German Society for Biochemistry and Molecular Biology @GBM_eV had its first symposium in Kaiserslautern. Exciting meeting with excellent talks and posters! So much fun! Next year, we organelle lovers meet in Düsseldorf!
From @Spang_Lab & @DrBakhtiar_S lab: LRBA gene mutations linked to severe childhood immune disorders involve Arf1-dependent pathways. These insights into endosomal traffic regulation may open doors to innovative treatments for LRBA deficiency hubs.la/Q02Rdsbx0#lysosome
The result of the wonderful collaboration with @DrBakhtiar_S lab is out! Great job @ViktriaSzentgy1 and Leon Lueck!
Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis rupress.org/jcb/article/223/…
Awesome meeting bridging cell polarity, membrane and RNA trafficking with cell fate determination. Very interactive and collaborative community pushing boundaries meeting in a very beautiful place.
Save the date for the EMBO workshop on Cell polarity and membrane dynamics organized by Ed Munro and myself! 18-23 May 2025 in the beautiful San Feliu! Signup here to get more info as soon as the website is up! please RT coming-soon.embo.org/w25-32
I am feeling honoured 🎉 to have received the FEBS Letters poster prize at the #FOR2625#Lysosomes & #Autophagy Symposium in Berlin last week. Many inspiring discussions and great talks!
@Spang_Lab 🔬🧫
#LipidDroplets friends: A new review collection on our most favourite organelle is out! I has been a great pleasure to compile this Special Issue together with @MariaBohnert for FEBS Letters. Thanks to all authors for their amazing contributions!