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SpanglerLab @SpanglerLab

The Spangler Lab at Johns Hopkins University integrates structural biology, molecular engineering, and translational immunology to design new disease therapies.

Joined May 2018
  • Tweets 93
  • Following 87
  • Followers 827
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Thrilled to share our new article in @acsnano on the use of a hydrogel-based platform developed by the lab of @dinodicarlo for immune phenotyping at the single cell scale: doi.org/10.1021/acsnano.4c18…

Specific Stimulation and Multiplex Secretion Analysis of T Cells Using a Suspendable Hydrogel...

The ability to characterize and separate cells based on their surface marker expression profiles using flow cytometry revolutionized our understanding of the immune system at the level of single...

pubs.acs.org
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Delighted to share our new article in @MolTherapy on novel bispecific VEGF antagonist proteins for treatment of eye diseases: sciencedirect.com/science/ar…
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Thrilled to share our new collaborative research on CAR NK cell engineering with @BonifantLab just published in JITC: jitc.bmj.com/content/13/2/e0…
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Excited to share our lab's new review article in @trendscancer, surveying recent work in engineering growth factor systems to advance cancer therapy: cell.com/trends/cancer/fullt…
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SpanglerLab retweeted
Johns Hopkins BME@JHUBME
25 Sep 2024
Exciting news! #HopkinsBME research landed the cover of @JCI_insight for September.
JCI insight
@JCI_insight
24 Sep 2024
A complex approach for antitumor activity: insight.jci.org/articles/vie… The Cover features study by Elissa Leonard, Jakub Tomala et al. They engineered a cytokine/antibody fusion protein with important implications for future immunocytokine development. @SpanglerLab @HopkinsMedicine
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So honored to have our cytokine/antibody fusion protein work featured on the cover of @JCI_insight! Huge thanks to Ann Seliger for the beautiful illustration. insight.jci.org/9/18

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Excited to share our latest work by Elissa Leonard, Jakub Tomala, and colleagues on the the design of cytokine/antibody fusion proteins for cancer immunotherapy published in @JCI_insight! insight.jci.org/articles/vie…
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SpanglerLab retweeted
Cell Chemical Biology@CellChemBiol
16 May 2024
👀Preview of Ludwig et al.: Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1 by Gordana Wozniak-Knopp and Veronica Natale at @BOKUvienna @acibGmbH dlvr.it/T6znCd

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Congratulations to Seth, Pao, Ben, and team on their new multiparatopic downregulating antibody article in @CellChemBiol! Huge thanks to our fantastic collaborators as well! @hdooley13 @Imaging4Health doi.org/10.1016/j.chembiol.2…

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Thrilled to share that Dr. Spangler has been promoted to Associate Professor with Tenure in the departments of Biomedical and Chemical & Biomolecular Engineering at Johns Hopkins. Deeply grateful for the trainees, mentors, colleagues, and collaborators who made this all possible!
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The Spangler Lab is deeply honored and grateful to receive a Stage 2 Damon Runyon-Rachleff Innovation Award from the Damon Runyon Cancer Research Foundation @DamonRunyon! damonrunyon.org/news/entries…

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Congratulations to Justyn, Pao, and Ben on their fantastic antibody article out in Annual Review of Chemical and Biomolecular Engineering! @AnnualReviews annualreviews.org/doi/10.114…

Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease Treatment

Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical compounds. However, monoclonal antibodies, which specifically engage only one target, often lack the mechanistic...

annualreviews.org
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Congratulations to Jakub Tomala and Shanelle Cao on their new review article on anti-cytokine antibodies in Journal of Immunology @J_Immunol! doi.org/10.4049/jimmunol.230…
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SpanglerLab retweeted
Susanna F. Greer, Ph.D.@susannagreer
30 Nov 2023
Check out my latest article: I’m stuck on how great this research is! linkedin.com/pulse/im-stuck-… via @LinkedIn

I’m stuck on how great this research is!

In this week’s article I’m glued to a study from the V Foundation grantee Dr. Jamie Spangler at The Johns Hopkins University.

linkedin.com
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SpanglerLab retweeted
Green Group@JGreenGroup
1 Dec 2023
Jan '24 #Workshop #Advances in #Immunoengineering! FREE Registration jhtie.jhmi.edu/training-upco… Exciting speakers include: @scienceempress @JennyNJiang @michal_bassani Dan Campbell Sharon Gerecht & more! @NIBIBgov @HopkinsMedicine @HopkinsEngineer @INBT_JHU @JHUBME @TTECJHU
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Congratulations to Luke Tomasovic (@luketomasovic11), Kathy Liu, Dr. Derek VanDyke, and Charina Fabilane on their new review article on IL-2 therapies for autoimmune diseases out in @BioDrugsJournal! doi.org/10.1007/s40259-023-0…

Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases

BioDrugs - The interleukin-2 (IL-2) cytokine plays a crucial role in regulating immune responses and maintaining immune homeostasis. Its immunosuppressive effects have been harnessed...

link.springer.com
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Delighted to share recent PhD laureate Dr. Aliyah Silver's new article on engineering a tumor-targeted cytokine/antibody fusion protein in @CellRepMed! Thanks to @JGreenGroup and @jishiharalab for working together with us on this story. doi.org/10.1016/j.xcrm.2023.…
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Congratulations to Derek and Paul on their new article in Journal of Biological Chemistry! @jbiolchem doi.org/10.1016/j.jbc.2023.1…
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Congratulations to Derek and Paul on their new article in Journal of Biological Chemistry! @jbiolchem doi.org/10.1016/j.jaut.2023.…

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Sorry -- wrong link! doi.org/10.1016/j.jbc.2023.1…
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