ALT Infographic titled "The Fetal Frontier: A Review of Current and Emerging Fetal Therapies for Genetic Diseases" covering the 2000s-2020s. Goal: to evaluate current and future approaches for in-utero treatment of genetic disorders. Key prenatal treatments include maternal drug therapy, fetal enzyme replacement for deficiencies, stem cell therapy, and gene therapy to target genetic mutations. Reasons to treat before birth: immune tolerance to therapies, more permeable blood-brain barrier, and prevention of irreversible organ damage. Current limitations: most therapies remain experimental, ethical and safety considerations, and the need for careful patient selection. Conclusion: New prenatal gene and molecular therapies are emerging, and more clinical trials in fetal therapy and multidisciplinary fetal treatment programs are needed. Authored by Brown CG et al., Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center.

ALT Alt text: An informational graphic from Cincinnati Children's presents a true or false question. It asks if starting CDH babies on a scheduled sedation drip uses more sedation overall than PRN dosing. The options "True" and "False" are shown in bold circles. Instructions say, "Make your call, then swipe." An illustration of an infant and a right arrow suggest swiping right.

ALT A graphic features a statement labeled as "False" in bold red, correcting a claim about sedation use. It explains that Cincinnati Children's Hospital saw a decrease in overall sedation after switching from PRN to scheduled drips. A photo of a man in a suit is included, alongside his quote emphasizing the reduced sedation levels. Logos and an arrow with "Swipe right" are present.

ALT Alt text: A graphic from Cincinnati Children's compares two medical approaches: "OLD: PRN" and "NEW: Scheduled Drip." The PRN approach involves reacting after a baby shows distress, leading to escalating doses. The Scheduled Drip method starts sedation early to prevent crises. The text highlights that early standardized intervention breaks the reactive dosing cycle. The top right corner has Cincinnati Children's logo, and there's a "Swipe right" icon at the bottom.

ALT Alt text: A Cincinnati Children's infographic titled "The Principle" emphasizes early stabilization over reactive treatment. It highlights that capturing CDH babies early with predictable dosing reduces sedation compared to chasing crises, as part of a broader protocol overhaul that increased survival from 70% to 80%. The bottom text advises, "Standardize early. Don't chase late." The graphic includes a target icon and the Cincinnati Children's logo.

ALT Promotional graphic titled "Tell Us Your Experience!" announcing that GlobalCastMD and University Hospitals are conducting research investigating disparities in academic journal accessibility. They are recruiting any adults who read medical journals to participate in an anonymous survey study. Includes the GC and University Hospitals logos, with a contact note: "For questions please contact Jill Knepprath (jill.knepprath@uhhospitals.org)."

ALT Infographic titled "Rectal Prolapse Repair After Anorectal Malformation (ARM) Surgery" from a retrospective study of 85 patients (J Pediatr Surg, 2025). The problem: rectal prolapse is a known complication after ARM surgery, but the morbidity of repair isn't well described. Key results: 85 patients reviewed, representing 6.7% of all ARM patients, with 30.6% experiencing recurrent prolapse and 31.8% developing stricture. Key finding: stricture risk was 2.5 times higher when repairing asymptomatic prolapse (41% stricture rate) compared to symptomatic prolapse (16% stricture rate). Other risks: ostomy takedown with repair was associated with more recurrence, while repair technique made no difference. Takeaway: treat asymptomatic prolapse expectantly and counsel all patients on the risk of post-op stricture. From Nationwide Children's. PubMed: 40204270.

ALT CDH survival had been stuck at 70% for two decades. After a protocol overhaul at Cincinnati Children's, where did it land? Take a guess: __%. Make your call, then swipe right. Logo of Cincinnati Children's at the top.

ALT Answer slide reading "After 20 years of stasis, Cincinnati Children's just broke the 70% wall." CDH survival went from 70% to 80%, a 10-point increase after two decades of no movement. Made possible by Cincinnati Children's, with their logo displayed. Includes a "Swipe right" arrow.

ALT Slide titled "What They Changed: A system-by-system overhaul, Aug 2023 to Spring 2024." Lists six protocol changes: ventilator peak pressure capped at 22, ECMO earlier initiation if needed, repair at 12-24 hours on ECMO or days 4-8 off, BP support with hydrocortisone for every baby, feeds with TPN until baby can feed by mouth, and sedation as a scheduled drip rather than PRN. Philosophy: "Protect the lungs. Everything else falls in line." Made possible by Cincinnati Children's, with their logo displayed.

ALT Slide titled "The Results" comparing 99 old-cohort babies vs. 36 new-cohort babies: survival went from 70% to 80%, median ventilator time dropped about 50% to 9 days, and ECMO survival went from 70% to 55%. ECMO use was essentially unchanged (41% to 45%), indicating the improvement was not driven by more ECMO. Made possible by Cincinnati Children's, with their logo displayed.

ALT Infographic titled "Comparison of Prenatal Lung Volume Measurements Associated with ECMO Utilization & Mortality in Congenital Diaphragmatic Hernia (CDH)." A retrospective cohort study from 2012-2023 involving 132 patients with left and right-sided CDH. Early gestation imaging median is 24.6 weeks; late is 32-34 weeks. Two key metrics: Observed-to-Expected Total Fetal Lung Volume (O/E TFLV) and Percent Predicted Lung Value (PPLV). O/E TFLV is the best predictor for ECMO need and mortality. PPLV is noted for left CDH and ECMO use in right CDH. Conclusion highlights MRI-based lung volume measurements for improved risk stratification. Includes logos for Cincinnati Children's and @StayCurrentMD.