🧵The Neurobiology of Depression
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“A unified theory of depression conceptualises MDD as a matrix of genetic, epigenetic, and environmental factors that interact with personality vulnerabilities that predispose an individual to information processing biases, stress reactivity, and belief formation that precipitate pathophysiological mechanisms across molecular, cellular, circuit, and behavioural levels.”
Overall, in this new model, although depression cannot accurately be considered a deficit in serotonin, serotonin still has a role to play through its interactions with mechanisms of neuroplasticity. 17/17