Assistant Professor at UT Southwestern Medical Center studying how glial cells sculpt the nervous system. Views are my own.
Joined September 2019
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50 Photos and videos
Excited to introduce four new mouse lines described in our recent study @YiheZhang97 (soon available from JAX), including two lines for studying TFEB in broader contexts (TFEB 6xMyc, JAX#041044; Rosa26-TFEBS141A;S210A-Halo, JAX#041043) and two new KI lines for myelinating OLs.
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Excited to share our recent PNAS paper (led by @Dani_B1256): pnas.org/doi/10.1073/pnas.25…, where we discovered the mechanisms governing myelin integrity during the onset of myelination. We are grateful to collaborate with Ellisman lab (UCSD), @WertLaboratory, and UTSW EM Core (1/6).
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This work was supported by UTSW Endowed Scholar Funds @UTSWMedCenter, @utsweye, @UTSWBrain, @NatEyeInstitute, @klingensteinorg, @czi.
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Lu Sun retweeted
The 2026 Klingenstein Fellowship Awards in Neuroscience Conference brought together current and past fellows, distinguished advisors, and colleagues for top-notch science, engaging discussions, slide and poster presentations, and community-building.
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Today we say goodbye to @ZhangTingxin, an outstanding postdoc and research scientist in our group, as he begins his independent lab at SUSTech (the first one from our lab!). He published our group’s first paper and has another under review. Congratulations and best of luck!!
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OBI Investigator, Lu Sun, Ph.D. (right), & Aksheev Bhambri, Ph.D., developed a new research tool that sheds light on myelination. Learn how the discovery is providing deeper understanding of how neurological disorders like multiple sclerosis develop. bit.ly/49PPmEZ
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Glad to share our published version: “ Genetic targeting of premyelinating oligodendrocytes reveals activity-dependent myelination mechanisms”, led by @AksheevB
nature.com/articles/s41593-0…
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We made the Enpp6-CreERT2 mice available from Jax: jax.org/strain/041040
and updated the premyelinating oligodendrocyte multiomic website: utswbioinformatics.shinyapps…
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Lu Sun retweeted
12 Oct 2025
A terrific new opportunity for new or early career faculty to join the outstanding and rapidly growing faculty of @UTSWBrain. Spread the word!
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Lu Sun retweeted
1 Oct 2025
Thanks to everyone for an amazing Myo Life celebration of the 40-year anniversary of the Olson Lab, along with a big birthday. Here's my special song for the occasion, "The Ballad of Myo Life". Rock on! 😎 @UTSWMedCenter
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Excited to introduce four new mouse lines described in our recent study @YiheZhang97 (soon available from JAX), including two lines for studying TFEB in broader contexts (TFEB 6xMyc, JAX#041044; Rosa26-TFEBS141A;S210A-Halo, JAX#041043) and two new KI lines for myelinating OLs.
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The two knock-in mouse lines for myelinating oligodendrocytes are Mog-IRES-iCre (JAX#041041) and Mog-IRES-iCreERT2 (JAX#041042) with high efficient and specificity (no tamoxifen-independent recombination). If interested, please let JAX know so that they will not be cryopreserved.
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Lu Sun retweeted
11 Sep 2025
Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function dlvr.it/TN1B6G
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Excited to share the preprint led by Aksheev, a super talented postdoc in lab, in tackling the most mysterious stage during oligodendrogenesis and myelination: the premyelinating oligodendrocytes (1/n).
28 Dec 2024
New preprint out from Sun Lab @SunLab19 We generated new premyelinating oligodendrocyte specific Cre mouse line and show that preOLs can remain immature for upto 8days in vivo. These immature cells can also respond to changes in neuronal activity. (1/2)
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(9/n) Lastly, we have created a user-friendly website harboring snRNAseq dataset of genetically labeled preOLs: utswbioinformatics.shinyapps…. We hope to make this genetic reagent available to the field soon after publication.
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We are so grateful to collaborate with Guoqiang Yu's group at Tsinghua University, Jun Hee Kim's group at U Mich, and Chao Xing's group at UTSW. This work is supported by @UTSWMedCenter endowed scholar, @czi, @NIH_CommonFund, and @klingensteinorg.
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