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Tantillo Lab @TantilloLab
Joined January 2021
  • Tweets 337
  • Following 901
  • Followers 1,645
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Tantillo Lab@TantilloLab
Feb 20
We have moved to Bluesky and this account will no longer be active. Please find us at bsky.app/profile/tantillogro…
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Tantillo Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
28 Oct 2025
Post-transition State Bifurcations in Reactions That Form Pimarenyl Cation Diastereomers─Implications for Terpene Biosynthesis | Journal of the American Chemical Society @ucdavis @TantilloLab @UCDChem pubs.acs.org/doi/10.1021/jac…

Post-transition State Bifurcations in Reactions That Form Pimarenyl Cation Diastereomers─Implicat...

The role of post-transition state bifurcations in carbocation rearrangements derived from copalyl diphosphate (CPP) and its diastereomers syn-CPP and ent-CPP were investigated using quantum chemical...

pubs.acs.org
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2,710
Dynamic Inner-/Outer-Sphere Ligand Exchange in P(V)═O Reduction by Sacrificial Methods pubs.acs.org/doi/abs/10.1021…

Dynamic Inner-/Outer-Sphere Ligand Exchange in P(V)═O Reduction by Sacrificial Methods

Reduction of P(V)═O bonds via sacrificial methods holds broad prospects for industrial applications and mechanistic studies. Using our recently reported catalytic sacrificial system as a model, we...

pubs.acs.org
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343
Post-transition State Bifurcations in Reactions That Form Pimarenyl Cation Diastereomers─Implications for Terpene Biosynthesis pubs.acs.org/doi/10.1021/jac…

Post-transition State Bifurcations in Reactions That Form Pimarenyl Cation Diastereomers─Implicat...

The role of post-transition state bifurcations in carbocation rearrangements derived from copalyl diphosphate (CPP) and its diastereomers syn-CPP and ent-CPP were investigated using quantum chemical...

pubs.acs.org
1
8
374
Enantioselective Synthesis of Complex Carbocycles by C–H Insertion of Aryl/Aryl Carbenes pubs.acs.org/doi/10.1021/acs…

Enantioselective Synthesis of Complex Carbocycles by C–H Insertion of Aryl/Aryl Carbenes

A range of benzene and indole-fused carbocyclic molecules were accessed by the enantioselective C–H insertion of rhodium aryl/aryl carbenes. 1,4, 1,5, and 1,6 C–H insertion reactions are chemoselec...

pubs.acs.org
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1,867
Direct N–SF5 and N–SF4CF3 Bond Formation through Strain-Release Functionalization of 3-Substituted [1.1.0]Azabicyclobutanes pubs.acs.org/doi/full/10.102…

Direct N–SF5 and N–SF4CF3 Bond Formation through Strain-Release Functionalization of 3-Substituted...

In comparison to modern methods for carbon–SF5 bond formation, methods for direct heteroatom–SF5 bond formation are exceptionally scarce, rendering motifs such as “N–SF5” virtually unexplored in the...

pubs.acs.org
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1,656
Tantillo Lab retweeted
UC Davis Department of Chemistry@UCDChem
21 Jul 2025
Professor Dean Tantillo @TantilloLab has received the 2025 ACS Edward Leete Award! This national award from the Division of Organic Chemistry honors outstanding contributions to teaching and research in Organic Chemistry. Congratulations! organicdivision.org/blog/new…

UC Davis’s Dean J. Tantillo is the 2025 Leete Awardee | ACS Division of Organic Chemistry

The ACS Division of Organic Chemistry is pleased to announce that Professor Dean J. Tantillo (University of California, Davis) has been selected as the...

organicdivision.org
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PeriRxn, a Tool for Assessing Pericyclicity through Nucleus-Independent Chemical Shifts and Normalized Multicenter Bond Orders pubs.acs.org/doi/full/10.102…

PeriRxn, a Tool for Assessing Pericyclicity through Nucleus-Independent Chemical Shifts and...

Analyses of nucleus-independent chemical shifts (NICS) and normalized multicentered bond orders (nMCBO) along reaction coordinates were used to quantify the degree of cyclic delocalization occurring...

pubs.acs.org
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1,067
Dynamically controlled kinetic selectivity in reactions promoted by transition metal catalysts cell.com/chem-catalysis/full…
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1,495
Diazacyclobutenes as Reactive Intermediates: The Cascade Cyclization of Thiolated Ene-ynes and Azodicarboxylates to Provide Tetrahydroindoles pubs.acs.org/doi/abs/10.1021…

Diazacyclobutenes as Reactive Intermediates: The Cascade Cyclization of Thiolated Ene-ynes and...

We describe a new one-pot synthesis to access richly functionalized tetrahydroindoles and related fused pyrroles. The key to this transformation is a robust cascade cyclization between ene-yne...

pubs.acs.org
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2,515
Tantillo Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
1 May 2025
Avoidance of Secondary Carbocations, Unusual Deprotonation, and Nonstatistical Dynamic Effects in the Cyclization Mechanism of Tetraisoquinane | Journal of the American Chemical Society @ucdavis @UCDavisResearch @TantilloLab @UF pubs.acs.org/doi/10.1021/jac…

Avoidance of Secondary Carbocations, Unusual Deprotonation, and Nonstatistical Dynamic Effects in...

The complexity and versatility of terpene cyclization reactions contribute to the wide variety of functions and properties that terpenoid compounds exhibit in nature. The management of reactive...

pubs.acs.org
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5,289
Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of Ketomemicin Analogs in Salinispora mdpi.com/1660-3397/23/3/126

Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of...

Pseudopeptides are attractive agents for protease inhibition due to their structural similarities to the natural substrates of these enzymes, as well as their enhanced stability and resistance to...

mdpi.com
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267
Avoidance of Secondary Carbocations, Unusual Deprotonation, and Nonstatistical Dynamic Effects in the Cyclization Mechanism of Tetraisoquinane pubs.acs.org/doi/10.1021/jac…

Avoidance of Secondary Carbocations, Unusual Deprotonation, and Nonstatistical Dynamic Effects in...

The complexity and versatility of terpene cyclization reactions contribute to the wide variety of functions and properties that terpenoid compounds exhibit in nature. The management of reactive...

pubs.acs.org
1
25
970
Convenient synthesis and antiproliferative activity of 2-(Indol-2-yl)-2-arylacetamides sciencedirect.com/science/ar…
1
354
Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key Residues Critical for Mono-, Bi-, and Tricyclic Sesquiterpenes Formation pubs.acs.org/doi/10.1021/jac…

Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key...

Sesquiterpene synthases (STSs) catalyze carbocation cascade reactions with various hydrogen shifts and cyclization patterns that generate structurally diverse sesquiterpene skeletons. However, the...

pubs.acs.org
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1,121
Tantillo Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
13 Mar 2025
Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key Residues Critical for Mono-, Bi-, and Tricyclic Sesquiterpenes Formation | Journal of the American Chemical Society @TantilloLab @UCDChem @PKU1898 pubs.acs.org/doi/10.1021/jac…

Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key...

Sesquiterpene synthases (STSs) catalyze carbocation cascade reactions with various hydrogen shifts and cyclization patterns that generate structurally diverse sesquiterpene skeletons. However, the...

pubs.acs.org
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5,390
Efficient and modular synthesis of ibogaine and related alkaloids nature.com/articles/s41557-0…

Efficient and modular synthesis of ibogaine and related alkaloids

Nature Chemistry - Preliminary clinical trials suggest that ibogaine and its active metabolite noribogaine have powerful anti-addictive properties, Now, a strategy for the scalable, asymmetric...

nature.com
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1,347
Vibrationally Assisted Tunneling through the Bread of a Proton Sandwich─Connections to Dynamic Matching pubs.acs.org/doi/full/10.102…

Vibrationally Assisted Tunneling through the Bread of a Proton Sandwich─Connections to Dynamic...

Proton sandwiches are unusual nonclassical carbocations characterized by a five-center, four-electron bonding array which rapidly isomerize to lower energy isomers with three-center, two-electron...

pubs.acs.org
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Tantillo Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
5 Feb 2025
Vibrationally Assisted Tunneling through the Bread of a Proton Sandwich─Connections to Dynamic Matching | Journal of the American Chemical Society @ucdavis @UCDChem @gabepgomes @CarnegieMellon @gpggrp pubs.acs.org/doi/10.1021/jac…

Vibrationally Assisted Tunneling through the Bread of a Proton Sandwich─Connections to Dynamic...

Proton sandwiches are unusual nonclassical carbocations characterized by a five-center, four-electron bonding array which rapidly isomerize to lower energy isomers with three-center, two-electron...

pubs.acs.org
10
45
7,035
Tantillo Lab retweeted
J. Am. Chem. Soc.@J_A_C_S
31 Jan 2025
Post-Transition State Bifurcation Leading to Diradical & Zwitterionic Intermediates: Controlling Nonstatistical Kinetic Selectivity via Solvent Effects | Journal of the American Chemical Society @UWMadisonChem @UWMadison @UCDChem @ucdavis pubs.acs.org/doi/10.1021/jac…

Synthetically Relevant Post-Transition State Bifurcation Leading to Diradical and Zwitterionic...

A post-transition state surface intersection (PTSSI) between radical and zwitterionic states that causes a bifurcation in the reaction pathway was discovered through density functional theory...

pubs.acs.org
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