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AgingResearch @TheAgingField

#Aging, #AntiAging, #Longevity, #AgeRelatedDisease, #Health, #Geriatrics, #Gerontology, #Nutrition, #StemCells, #Science, #Technology

Joined December 2019
  • Tweets 6,646
  • Following 304
  • Followers 5,205
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Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications eurekaselect.com/article/136…

Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications

Cellular senescence, an eternal condition of cell cycle arrest due to cellular stressors, is a sign of aging. Senescent cells (SCs) build up in tissues as they age, impairing their ability to repair...

eurekaselect.com
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CellBiAge: Improved single-cell age classification using data binarization cell.com/cell-reports/fullte… @CellReports
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Implication of Oxysterols and Phytosterols in Aging and Human Diseases link.springer.com/chapter/10…
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Aging Science News
@AgingBiology
3 Dec 2023
Targeting the redox system for cardiovascular regeneration in aging onlinelibrary.wiley.com/doi/…

Targeting the redox system for cardiovascular regeneration in aging

Aging is linked to impaired cardiovascular regeneration, with age-related redox imbalances promoting senescence pathways in cardiac and endothelial stem/progenitor cells. These mechanisms attenuate...

onlinelibrary.wiley.com
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john morley@drjohnmorley
3 Oct 2023
USA needs to improve its medical care
Daniel Kraft, MD
@daniel_kraft
3 Oct 2023
Life Expectancy: The US in recent decades went from the middle of the pack to being an outlier. And it continues to fall further and further behind. Chronic diseases are the greatest threat, killing far more people between 35-64 every year… washingtonpost.com/health/in…
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A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer's disease pnas.org/doi/10.1073/pnas.23… @PNASNews

A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer’s disease...

The amyloid-beta peptide (Aβ) is a driver of Alzheimer’s disease (AD). Aβ monomers can aggregate and form larger soluble (oligomers/protofibrils) a...

pnas.org
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Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells link.springer.com/article/10…
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Mike Lustgarten, PhD
@mike_lustgarten
29 Aug 2023
Hyperhomocysteinemia and Accelerated Aging: The Pathogenic Role of Increased Homocysteine in Atherosclerosis, Osteoporosis, and Neurodegeneration pubmed.ncbi.nlm.nih.gov/3760…

Hyperhomocysteinemia and Accelerated Aging: The Pathogenic Role of Increased Homocysteine in...

Cardiovascular diseases and osteoporosis, seemingly unrelated disorders that occur with advanced age, share major pathogenetic mechanisms contributing to accelerated atherosclerosis and bone loss....

pubmed.ncbi.nlm.nih.gov
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Alzforum@alzforum
23 Aug 2023
Switching astrocytes from expressing APOE4 to APOE2 reduced plaques, gliosis, and bettered memory in a mouse amyloidosis model. This may help guide APOE replacement therapies. #AAIC2023 ow.ly/7yfZ50PCzB9
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The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease nature.com/articles/s41580-0… @NatRevMCB

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Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans "A possible mechanistic explanation for this finding is that ether lipids are required for activation of longevity-promoting, metabolic stress defenses downstream of the conserved transcription factor skn-1/Nrf...." elifesciences.org/articles/8…
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The Lipid Chronicles@lipidchronicles
21 Aug 2023
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired buff.ly/3EaaVAx (@NatureComms)
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Cell Metabolism@Cell_Metabolism
21 Aug 2023
New! Online now: Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease dlvr.it/StynhD

Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in...

Circadian alterations are prevalent in patients with Alzheimer’s disease (AD). Whittaker et al. report circadian disruptions, which emerge at early pathology stages, in AD mouse models. The applica...

cell.com
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john morley@drjohnmorley
18 Aug 2023
Frailty Is a Risk Factor for Falls in the Older Adults: A Systematic Review and Meta-Analysis pubmed.ncbi.nlm.nih.gov/3735…
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Declan O'Regan@DrDeclanORegan
21 Aug 2023
How old is your heart? We looked at genetic differences and risk factors that affect the age of the heart and circulation. Our new paper in @NatureComms points to genes regulating inflammation and stress response. #whyCMR nature.com/articles/s41467-0…

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lada
@ladanuzhna
1 Aug 2023
impetusgrants.org/apply @impetusgrants applications are now open (1-31st of August) If you are a scientist but you never worked on aging. If you are a Ph.D. student with good ideas. If you are a postdoc deciding on the direction of your future lab. Come join the good pursuit. We don't look for credentials and direct experience in aging. Only excellent ideas and the ability to get things done. impetusgrants.org/news-and-u… - also wrote a note on the types of things that tended to succeed with Impetus in the past

Impetus Grants — Norn Group

norn.group
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Veera Rajagopal 
@doctorveera
21 Aug 2023
DNA spill from mitochondria into the cytosol of microglia triggers cGAS-STING causing inflammation and faster ageing in mice. Do STING inhibitors have the potential to slow down brain ageing and associated pathology? It seems to work in mice. Soon someone will test it in humans. Nice In-the-pipeline blog post by Derek Lowe (science.org/content/blog-pos…) on a recent Nature article by Gulen et al. (nature.com/articles/s41586-0…). The illustration below is from the accompanying News and Views by Bart Eggen (nature.com/articles/d41586-0…).
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Lulu Cambronne@LACambronne
21 Aug 2023
Human mitos can alter their local redox environment by selectively uptaking oxidized NAD . Find out more about the molecular mechanisms of this regulation, as well as the influence from the local lipid environment embopress.org/doi/full/10.15…

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PrudencioLab@PrudencioLab
21 Aug 2023
Cryptic RNAs in Alzheimer’s brains with TDP-43 pathology! New work from @PrudencioLab and wonderful colleagues at Mayo Clinic! Shout out to Virginia Estades Ayuso, her first author publication! molecularneurodegeneration.b…

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Molecular Neurodegeneration - Inclusions of TAR DNA-binding protein 43 kDa (TDP-43) has been designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without...

link.springer.com
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Longitudinal study of epigenetic aging and its relationship with brain aging and cognitive skills in young adulthood 🔎Epigenetic age gap (EpiAGE) shows a "small relationship with accelerated brain aging," and women-specific "worse performance IQ." frontiersin.org/articles/10.…
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