Associate Professor @UZH_en @Unispital_USZ @CCCZ_USZ studying the pathogenesis of cancer with a particular focus on TP53-mutant myeloid (pre-)malignancies
Joined May 2019
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🔥New paper from our lab @UZH_en @Unispital_USZ @CCCZ_USZ 🔥
#ERCC6L2 disease is a relatively recently described inherited bone marrow failure syndrome. It is strongly associated with somatic #TP53mutations and #AML or #MDS development. 1/7
ashpublications.org/blood/ar…
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Boettcher Lab retweeted
At #EHA2026, the #HemaSphereAwards recognize authors of influential hematology publications. Congratulations to Ana LuĂsa Pereira, Serena Galli, and CĂ©sar Nombela-Arrieta for their study on bone marrow niches for hematopoietic stem cells👉onlinelibrary.wiley.com/doi/…
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Boettcher Lab retweeted
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr
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Boettcher Lab retweeted
Ercc6l2 deficiency leads to replication stress, p53 pathway activation, and decreased Runx1 and Gata1 expression resulting in BMF. Read the plenary paper in Blood: ow.ly/nZ5l50YGL8b #plenarypaper #bloodjournal #p53
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I’m also very delighted to share the news that I have been promoted to #AssociateProfessor. @UZH_en @Unispital_USZ @CCCZ_USZ 🍾🥂🎉
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🔥New paper from our lab @UZH_en @Unispital_USZ @CCCZ_USZ 🔥
#ERCC6L2 disease is a relatively recently described inherited bone marrow failure syndrome. It is strongly associated with somatic #TP53mutations and #AML or #MDS development. 1/7
ashpublications.org/blood/ar…
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Bonus 1/2: Thanks to #Timothy_Chlon for his insightful commentary on our work!
ashpublications.org/blood/ar…
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Bonus 2/2: Thanks to #Dr. James D. Griffin for featuring our work on the @BloodPortfolio podcast. bloodpodcast.transistor.fm/e…
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Boettcher Lab retweeted
Welcome to #ESHAL2026!
Stay tuned! ESH Young Scientific Reporters @DKotsos & @TanMeg9595 will provide regular updates on the conference!
February 27-March 1, 2026
Chairs: @DombretHerve, Christoph Röllig, @DrWendyStock
#ESHCONFERENCES #leusm
@Hemasphere_EHA
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Boettcher Lab retweeted
Now online in @CD_AACR: Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators - by @FerranFeceCruz, @AndreasVarkaris, @aparna1024, Ryan Corcoran, and colleagues doi.org/10.1158/2159-8290.CD… @MassGenBrigham @MGBResearchNews @harvardmed
Jan 9
Now online: Acquired on-target alterations drive clinical resistance to p53-Y220C reactivators doi.org/10.1158/2159-8290.CD…
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17 Dec 2025
1/🔥 New paper from our lab!
#TP53-mutant clonal hematopoiesis (#CH) greatly increases risk for therapy-related #AML/MDS - but why?
We set out to dissect how mono- vs. biallelic #TP53 mutations drive leukemic evolution. nature.com/articles/s41375-0…
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8/🍾🎉 Congratulations to #JonasFullin and the entire team, and many thanks to all collaborators!
đź“„ Read the full paper here:
“The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis” nature.com/articles/s41375-0…
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