@TheGenomeLab profile picture
Greg Findlay @TheGenomeLab
Joined July 2011
  • Tweets 281
  • Following 297
  • Followers 1,244
39 Photos and videos
Pinned Tweet
Greg Findlay@TheGenomeLab
24 Mar 2025
Great to see this out now in @CellGenomics . A few points about what we learned in revisions over on BlueSky: bsky.app/profile/gregfindlay…

Greg Findlay@TheGenomeLab
2 Apr 2024
Our latest from @TheCrick, now on @biorxivpreprint: biorxiv.org/content/10.1101/… Michael Herger (@HergerMichael) and Christina Kajba jointly led development of a new prime editing platform for testing large numbers of human genetic variants.
3
444
Greg Findlay retweeted
David Balchin@balchin_david
27 Sep 2024
Join us for a PhD! Applications close November 5th. crick.ac.uk/careers-study/va…

1
3
4
1,440
Crick PhD recruitment for fall 2025 is officially open! Please apply to our lab through the Crick application portal if interested. 👇 crick.ac.uk/careers-study/va…

1
67
138
28,818
Greg Findlay retweeted
David Balchin@balchin_david
13 Aug 2024
New from our lab @TheCrick , led by @BetkaRoe. A fun side project that tried to understand what happens when a chaperonin encounters a translating ribosome. biorxiv.org/content/10.1101/…
1
13
61
4,494
Greg Findlay retweeted
Colleen Drapek@ColleenDrapek
15 Jul 2024
Come join us in making agriculture sustainable at @PhytoformLabs! 🌱We are looking for an R&D scientist with a background in Synthetic biology to join our tools & traits team for precision genome editing 🧬. If you think this could be you, please apply! linkedin.com/jobs/view/39723…

Assistant Professor Of Physics jobs in United States

Today's top Assistant Professor Of Physics jobs in United States. Leverage your professional network, and get hired. New Assistant Professor Of Physics jobs added daily.

linkedin.com
1
39
74
11,708
Greg Findlay retweeted
Nicky Whiffin@nickywhiffin
11 Jul 2024
So excited that our paper “De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome” is out today in @Nature nature.com/articles/s41586-0… 🧵 1/16

De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Nature - The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′...

nature.com
Yuyang Chen@quenchentin
11 Jul 2024
(1/4) I’m delighted to announce that our research on RNU4-2 is now out on @Nature . This is an exciting finding that will bring many diagnoses worldwide. We have updated some new results since the preprint: nature.com/articles/s41586-0…
12
101
325
97,680
Greg Findlay retweeted
The Francis Crick Institute@TheCrick
9 Jul 2024
We are delighted to announce that Professor Edith Heard has been appointed as our new director and chief executive! Edith, who is currently director-general at @EMBL, will succeed Paul Nurse in leading the Crick from the summer of 2025. 🔗 crick.ac.uk/news/2024-07-09_…
"The Francis Crick Institute has quickly established a global reputation for its work at the frontiers of science. I relish the challenge of building on that work. I also want to pay tribute to Sir Paul Nurse, without whom the Francis Crick Institute would not be the world-leading institution it is today." - Edith Heard

ALT "The Francis Crick Institute has quickly established a global reputation for its work at the frontiers of science. I relish the challenge of building on that work. I also want to pay tribute to Sir Paul Nurse, without whom the Francis Crick Institute would not be the world-leading institution it is today." - Edith Heard

19
121
600
125,919
Greg Findlay retweeted
Chloé Terwagne@ChloeTerwagne
5 Jul 2024
Want to fully investigate this large dataset beyond classical 2D formats? Go interactively explore the data 👇 vhl-board.onrender.com/

Greg Findlay@TheGenomeLab
5 Jul 2024
Replying to @TheGenomeLab
The VHL data can also be searched, visualised, and explored using this awesome SGE visualisation platform made by @ChloeTerwagne: vhl-board.onrender.com/ Chloé’s code is all on GitHub if you’re interested in viewing and sharing your own data like this. (3/n)
2
7
1,573
Massive thanks to all authors, but particularly @ChloeTerwagne, Athina Ganner, @LauraCubitt3, @ReidBrewer3, Dong-Kyu Kim & @Eivakine for key inputs to revisions. And, of course, many thanks to reviewers, @nature_genet, and funders @TheCrick @CRUKresearch (7/n)
1
1
796
Of course, we hope you read the paper and use the data. Do feel free to reach out with questions on anything from protocol tips to variant classifications. (8/n)
1
1
587
Finally, we’re delighted to see this published back-to-back with a massive SGE analysis of BAP1 led by Andrew Waters, @David_J_Adams and co. @sangerinstitute: nature.com/articles/s41588-0… So many more variants now readily interpretable, and still more on the way! (9/9)

Saturation genome editing of BAP1 functionally classifies somatic and germline variants

Nature Genetics - Saturation genome editing characterizes BAP1 variants and their association with disease presentation. A phenome-wide association analysis in the UK finds that BAP1 variants...

nature.com
1
2
19
1,736
Lots more new analyses and validations in the paper, too. For instance, comparing function scores to SpiceAI and FoldX computational predictions – both of which do reasonably well. (6/n)
1
516
In new experiments, we also characterise novel mechanisms made apparent by SGE. Specifically, we show that a long C-terminus extension leads to LoF via VHL protein destablization and that stop-codon readthrough can impact the degree of functional impairment. See Fig. 6! (5/n)
1
495
The VHL data can also be searched, visualised, and explored using this awesome SGE visualisation platform made by @ChloeTerwagne: vhl-board.onrender.com/ Chloé’s code is all on GitHub if you’re interested in viewing and sharing your own data like this. (3/n)
1
5
2,184
Importantly, we now split loss-of-function variants by SGE score into LOF1 (lowest) and LOF2 (depleted, weaker effect). In collaboration w Athina Ganner and Freiburg colleagues, we show how patients with VHL disease can be stratified by ccRCC risk using these categories. (4/n)
1
560
Our work led by @megan_buckley01 on Saturation Genome Editing of VHL is now out in @NatureGenet: nature.com/articles/s41588-0… Many new experiments and analyses to quickly highlight… (1/n)

Saturation genome editing maps the functional spectrum of pathogenic VHL alleles

Nature Genetics - Saturation genome editing characterizes von Hippel–Lindau (VHL) coding variants and their associations with diseases. Function scores for 2,268 VHL single-nucleotide...

nature.com
3
39
144
22,237
Most importantly, all SGE scores and variant classifications are available for download in Supplementary Table 1 and from MAVEdb (mavedb.org/experiments/urn:m…). Given the data’s high precision, we expect this will lead to a steep reduction in VUS reported clinically. (2/n)
1
1
1,057
Greg Findlay retweeted
Junhong Choi@_Choi_Junhong
11 Jun 2024
Our DNA Typewriter protocol (written by @LiaoHanna, @JShendure, and myself) is out! Thank you @NatureProtocols for writing/editing this with us and having it as this week’s #FeaturedProtocol :-)
Nature Protocols@NatureProtocols
11 Jun 2024
#FeaturedProtocol this week from Jay Shendure on using #DNATypewriter (#primeediting-based method) for tracing insertional events bit.ly/4cegahU
12
58
7,635
Greg Findlay retweeted
eriksahailab@eriksahailab
30 May 2024
Happy to share this opportunity to join our team. Please apply if you are interested, or re-post if you are not on the look out for a new job crick.wd3.myworkdayjobs.com/…
55
63
20,859
Greg Findlay retweeted
Michael Herger@HergerMichael
2 Apr 2024
Excited to see our work on the development of a platform for pooled screening of genetic variants using prime editing published on @biorxivpreprint: doi.org/10.1101/2024.04.01.5….

1
2
12
1,171
Load more