We are currently recruiting a Postdoctoral Researcher and a PhD Student to join our lab 👉 weiss-lab.com/pages

New paper in collaboration with @Cbv_SAS & @CharlesUniPRG on the effect of #homocysteine on the excitability of hippocampal neurons #ionchannels #homocysteinemia ➡️ rb.gy/etbwoj

New paper in collaboration between @Cbv_SAS & @CharlesUniPRG - Electrophysiological characterization of sourced human iPSC-derived motor neurons #ionchannels #mnd #als ➡️ rb.gy/5tdf7r

New paper from the lab - Functional characterization of a novel de novo #CACNA1C pathogenic variant in a patient with neurodevelopmental disorder #calcium #ionchannels #channelopathies @CharlesUniPRG ➡️ rb.gy/9teu05

Very interesting chemistry leading to the design of a dual ligand of the α2δ-1 subunit of voltage-gated calcium #ionchannels and the μ-opioid receptor for #pain therapy ➡️ rb.gy/82y57e

Thanks to Philippe Lory @IGF_Montpellier for this nice Commentary on our recent Review "The T-type #calcium channelosome" #ionchannels ➡️ rb.gy/z1pmve

#ionchannels #ALS #MND

Our paper on the mechanism of sensitisation of primary sensory neurons by DRG macrophages after nerve injury is out in @GLIA_Journal @WileyNeuro ! onlinelibrary.wiley.com/doi/…

REVIEW - Pathophysiology of Ion Channels in Amyotrophic Lateral Sclerosis - Here we discuss the role of #ionchannels in #ALS #MND, their implications on neuronal excitability, and potential as therapeutic target. Credit and congrats go to @RobinStringer ➡️ rb.gy/c24uj9

The final version of our @physiolrev editorial is published! Ion channel dysfunction is a hallmark for many diseases. Since ion channels are key therapeutic targets, we anticipate that unraveling new aspects of their dysfunction holds a huge potential towards novel treatments.

Fantastic lecture @IOCBPrague this morning by Gerald Zamponi @zymedyne on targeting T-type #calcium #ionchannels in chronic #pain. Personally very happy to have you in Prague! 🙏

A little rant about American universities, in the light on the recent Congressional testimony debacle: Today I learned that Harvard President Claudine Gay seems to have published only 11 peer-reviewed journal papers in her entire academic career. 'So what?', you might ask. Well, that's about the number you'd normally need to get hired as a first-year tenure-track assistant professor at a decent state university. It's the number I published in the 12 months before I got tenure. It's about the number that my more workaholic colleagues publish every year, decade after decade, throughout their careers. And it's less than 1% as many papers as get published by outstanding researchers like behavior geneticist Nick Martin (with over 1,500 journal papers). The situation at Harvard is not unusual. The leaders of academia are not typically leading academics, in the sense of highly productive researchers or widely respected teachers. One might say they are career bureaucrats - but that would misunderstand their crucial ideological function. The American people need to understand that in modern universities, both public and private, administrators function more like party political officers in communist Russian or Chinese universities. They are selected, throughour their careers, largely for their political commitments, and their willingness to enforce them. Like Cold War commissars, their allegiance is to the party, not to academia where they happen to work. I mean 'party' quite literally: the Democratic party. Most American university administrators are loyal Democrats, and can't really imagine why anyone wouldn't be. Very few are Republicans or Libertarians. And an increasing proportion of them are fully woke identitarian Leftists: they often launched their careers with a short series of papers on woke topics, using woke ideological frameworks, published in woke journals - before turning to the administrative track that offers much more political power to propagandize, indoctrinate, and control. 'So what?', you're might ask. I've seen many calls for university administrators to enforce the rules of classical liberalism and free speech more fairly. This is like asking a Soviet-era commissar to abandon their Communist party allegiance, and to develop an entirely new identity and ethos grounded in an ideology that they have spent their entire career fighting. It will not happen. Political animals do not change their spots. University presidents who have prioritized amassing ideological power over producing academic research will not suddenly rediscover the merits of open inquiry. They need to be fired, and replaced with academic leaders who are actually leading academics - rather than party political officers. mindingthecampus.org/2022/12…

Fun opportunity to write a Perspective for @jacionline on the role of peripheral sensory neurons in immunomodulation. #Neuroimmunology Peripheral somatosensory neurons listen and orchestrate the immune response 👇 sciencedirect.com/science/ar…

Check out our new review: Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors. @MariaKarela3 frontiersin.org/articles/10.…

Can you spot the mistake? 🤣

A structural atlas of druggable sites on Nav #ionchannels @tandfchannels ➡️ rb.gy/9jmbq3

POSTDOC POSITION - Pathophysiology of T-type #calcium #ionchannels in Slobo Todorovic' lab, Denver, Colorado 🇺🇸

Just out our new research paper! We identify PIEZO2-dependent rapid pain system in humans and mice. The work led jointly by @OtmaneBouchatta and @M_Brodzki in a close-knit joint effort of @saadsnagi and @SzczotLab groups. 🧵 1/10 👇doi.org/10.1101/2023.12.01.5…

REVIEW - The T-type calcium channelosome - Here we compiled the current knowledge surrounding T-type #calcium #ionchannels interactors, their physiological roles, and potential for drug-based therapeutic intervention ➡️ rb.gy/2z7vdt

Predatory but generous at least 🤨