PhD candidate investigating protein phase separation and other small scale phenomena | @knowleslabcamb @Cambridge_Uni
Joined October 2020
- Tweets 28
- Following 89
- Followers 102
- Likes 55
9 Photos and videos
Tim Welsh retweeted
20 Mar 2023
An amazing platform for ultrahigh throughput protein solubility screening! Check the paper:
pubs.acs.org/doi/10.1021/acs…
Well done Nadia, Tomas, @OellerMarc, @HAusserwoeger, Aviad, @TimWelsh_ , Rungzhang, @DaoyuanQian219, @VendruscoloLab, Sormanni lab and others!
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Tim Welsh retweeted
10 Feb 2023
Check out the new DigitISA assay for sensing biomolecular complexes in solution! Well done @GeorgKrainer @KadiLiisSaar @TimWelsh_ @magdaczek @BJacquat and colleagues from Owens, Alberti and Klenerman groups!
nature.com/articles/s41467-0…
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8 Feb 2023
Our paper on the digital sensing of protein:aptamer interactions is finally published! One platform shows the ability to sense everything from single proteins up to biomolecular condensates and exosomes, while elucidating many biophysical parameters. Congrats to all authors!
7 Feb 2023
📢 Finally out now: Our paper describing DigitISA, a platform for direct digital sensing of protein biomarkers in solution 🧪 (incl. antibodies, amyloid aggregates & condensates). @KnowlesLabCamb @ChemCambridge Take a look: 👇nature.com/articles/s41467-0…
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Tim Welsh retweeted
31 Dec 2022
A new method for determining the interaction strengths among compounds that form biomolecular condensates relies on measurements of just one solute in one phase.
Read go.aps.org/3Guq7L6
@DaoyuanQian219 @TimWelsh_ @AbellJonny @GeorgKrainer @MichaelsLabETH @KnowlesLabCamb
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Tim Welsh retweeted
16 Nov 2022
While antibodies have a remarkable track record in therapeutics, achieving sufficient specificity remains an issue. A Review in @NatRevChem discusses the physicochemistry of non-specificity and outlines future opportunities to improve protein binding. go.nature.com/3O8fK1y
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7 May 2022
En route to Heidelberg for the #EESPhaseSeparation conference. Only a few more countries to cross before Monday morning!
Come find me all week if you want to chat condensates, microfluidics, or bikes!
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Tim Welsh retweeted
10 Mar 2022
Check out our preprint discovering DNA-induced LLPS of antibodies based on surface patch driven non-specific interactions: biorxiv.org/content/10.1101/…
Great work by @HAusserwoeger, @GeorgKrainer, @TimWelsh_, Tomas, @SchneiderMatth & Therese. Exciting collaboration with @novonordisk
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25 Feb 2022
When theorists and experimentals collaborate good things happen @DaoyuanQian219. Excited to share our work on the measurement and mechanistic insights of tie-lines in biomolecular phase diagrams. Also, maybe we should stop calling PEG an "inert crowder"?
biorxiv.org/content/10.1101/…
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Tim Welsh retweeted
24 Feb 2022
More from @KnowlesLab at #bps2022 in #SanFrancisco. @eaandrzejewska @mus_greta, Alyssa & @TimWelsh_ presenting posters on pre-fibrilliar protein #aggregates and single-molecules studies, oligomer-membrane interactions, microfluidic spray-deposition & #biomolecular condensates.
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4 Feb 2022
Super happy to have contributed to this fantastic piece of work investigating the underlying nucleation mechanisms in solutions of phase separating proteins!
biorxiv.org/content/10.1101/…
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10 Jan 2022
Excited to share our recent work in @NanoLetters investigating the electrostatic forces that stablize protein condensates!
pubs.acs.org/doi/abs/10.1021…
Thanks to my amazing co-authors @GeorgKrainer, Jorge, @jerelleaj, @rcollepardo and more for their hard work!
@KnowlesLabCamb
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19 Jul 2021
Pretty stoked to finish 4th overall (3rd male) in the British 24hr Cycling Time Trial National Championships
Easily met my main goal of breaking the 55 year old Cambridge University record
Taking a day to recover before training loads of new students on microfluidics this week!
19 Jul 2021
Updated provisional overall result. Please let us know if any further issues.
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29 May 2021
Final #transengland21 activity. @theracingcoll
Will be back for more in the future and try to have less mechanicals...
strava.app.link/CdvlUQUOEgb
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