Mare meva. Definició de pilar:

Anyone else having issues with tiny holes in the bottom of @VWR tubes? This happened to me twice this week, luckily not with anything precious or radioactive (although having it happen with phenol:CHCl3 is not great!)!

RT @pardodevera: #NoPasarán, ‘on fire’ 😎 .@reuters .@playground

We are thrilled to announce that we finally have the approval for our Phase 1b study to test OMO-103 in metastatic PDAC patients in combination with standard of care in first line! This is another milestone for @peptomyc and its fantastic team. Stay tuned.

Rufian: "ERC ha tornat a guanyar dintre el bloc independentista". --- Acaba de perdre 417.000 vots. Quin desastre. Quina vergonya. Cal passar-los per sobre.

Disadvantages for non-native English speakers in scientific research. *propose a ‘concerted effort, at institutional level, to minimise the disadvantages for non-native English speakers’ * survivorship bias explains disappearing disadvantages journals.plos.org/plosbiolog…

Late to the party, just to say that this is changing biology as we know it. Protein complex prediction with AlphaFold-Multimer biorxiv.org/content/10.1101/…

Our chemogenetic tool SPARK-ON decouples phase separation from protein levels, drives condensate formation including transcription factors and cytosolic proteins e.g. G3BP1, enables dissection of the biological role of phase separation. Thanks @ACSCentSci. pubs.acs.org/doi/10.1021/acs…

Targeting Biomolecular Condensation and Protein Aggregation against Cancer | Chemical Reviews pubs.acs.org/doi/10.1021/acs…

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec. We explore 4 intracellular and intercellular applications of TransitID: - discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix) - mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress - discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery - analysis of proteins that traffic intercellularly bw tumor cells & macrophages Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor authors.elsevier.com/a/1hKLc…

Need to drug an intrinsically disordered protein (#IDP)? Why not try 19F #NMR transverse spin-relaxation? Check out our most recent work, now on @biorxivpreprint. @DFlemmingHansen @bhu_vaibhav @FigueiredoAm #NMRchat 🍝 💊 🧲 A 🧵👇🏽: (1/14) biorxiv.org/content/10.1101/…

👏 We are excited to introduce you to our new John Goldman Fellow for 2022 @Richardson_S_E, from @Cambridge_Uni. Find out more: leukaemiauk.org.uk/in-pursui… 🧵...

As my hols end and I fly back to the U.K. after spending nearly a whole day and costs getting tests and filling in multiple forms despite my COVID vax passport I do think this is a waste of time and money. Only 1 in 20 day two tests on return are being studied for variants now ..

Don't get swayed with opinionated news, read factual and quick news summaries in just 60 words with Crux - UK's Highest Rated News app, 100% Free

The coronavirus has had a devastating impact on our finances. As a result, today we presented a proposal to our staff that would mean us becoming smaller. It’s a sad day for everyone connected with our charity. 💔 Read our statement 👇 bloodcancer.org.uk/news/bloo…

THIS THIS THIS OVER AND OVER AGAIN. THIS. Please watch and share. Brilliantly and simply put.

As promised, here is the updated figure with data from yesterday. You can see how the UK epidemic is closely following Italy's, with a 14-15 day lag and the same doubling rate. We need a national lockdown by Monday just to be as badly hit as Italy. Time is running out.#UKlockdown

Incredible read, Science paper from the year 1919 about the Spanish flu pandemic: There is one and only one way to absolutely prevent it and that is by establishing absolute isolation.

Pués ya van tarde!!

New Article! Summary: Strong #coronavirus measures today should only take a few weeks, there wouldn’t be a peak of infections afterwards, and it can all be done for a reasonable cost to society, saving millions of lives along the way. medium.com/@tomaspueyo/coron…