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Shouhong Guang @WRnai

A nerdy worm

Joined December 2016
  • Tweets 147
  • Following 221
  • Followers 63
1 Photos and videos
A conserved antioxidant defense at the endoplasmic reticulum membrane: Cell Reports cell.com/cell-reports/fullte…

A conserved antioxidant defense at the endoplasmic reticulum membrane

Ji et al. identify ERGU-1/TMEM161B as an evolutionarily conserved ER-transmembrane protein that modulates oxidative stress generated during oxidative protein folding. This critical guardian maintains...

cell.com
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In @elife: Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans doi.org/10.7554/eLife.111326…
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Shouhong Guang retweeted
Qin Yan, PhD@QinYan1
Mar 28
I am really honored for this. This would not be possible without the hard work of my trainees, guidance by mentors including Joan and Ron Conaway @UTSWMedCenter , @kaelin_lab, David Stern, and Jeff Sklar, and support of my colleagues @yalepathology @YaleMed @Yale, and my family.
Yale Pathology
@yalepathology
Mar 26
Congratulations to @QinYan1, Professor of #Pathology @YaleMed, on being named a Fellow of the @aaas. This prestigious honor recognizes his extraordinary achievements as a research scientist. @YaleCancer
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Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans biorxiv.org/content/10.64898…
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Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in C. elegans' germline biorxiv.org/content/10.64898…
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Shouhong Guang@WRnai
26 Nov 2025
rdcu.be/eRT2i The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters
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Shouhong Guang@WRnai
23 Oct 2025
NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors: Cell Genomics cell.com/cell-genomics/fullt…

NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to...

Wang et al. performed a rare-variant-based association study and identified novel genes associated with hepatocellular carcinoma risk. The authors further revealed that NRDE2 promotes homologous...

cell.com
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Shouhong Guang@WRnai
27 Aug 2025
TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans sciengine.com/SCLS/doi/10.10… via @https://www.sciengine.com

TurboID-based proximity labeling identifies novel germline proteins that maintain E granule...

Germ granules are biomolecular condensates composed of RNA and proteins that play crucial roles in RNA metabolism and posttranscriptional gene regulation. C. elegans germ granules consist of multiple...

sciengine.com
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Shouhong Guang@WRnai
11 Aug 2025
rRNA intermediates dictate nucleolar architecture in C. elegans biorxiv.org/content/10.1101/…

rRNA intermediates dictate nucleolar architecture in C. elegans

The nucleolus is a multilayered, membraneless organelle essential for rRNA transcription, processing and ribosome assembly; however, it remains largely unclear whether and how these molecular events...

biorxiv.org
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piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation nature.com/articles/s41594-0…

piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation

Nature Structural & Molecular Biology - Piwi-interacting RNAs (piRNAs) are vital for genome integrity and fertility. Here the authors reveal that spatial clustering of piRNA genes in...

nature.com
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rdcu.be/ey2RV Comprehensive profiling of the catalytic conformations of human Guanylate kinase
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pmc.ncbi.nlm.nih.gov/article… Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation

Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation

In response to nutrient scarcity, cells must reallocate their limited energy for cellular maintenance at the expense of certain processes. How such a tradeoff is achieved remains largely unknown. RNA...

pmc.ncbi.nlm.nih.gov
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Shouhong Guang@WRnai
13 Jul 2025
Nucleolar proteomics revealed the regulation of RNA exosome localization by MTR4 - Molecular & Cellular Proteomics mcponline.org/article/S1535-…

Nucleolar Proteomics Revealed the Regulation of RNA Exosome Localization by MTR4

In BriefBiochemical fractionation followed by proteomics and fluorescent imaging approaches revealed the RNA helicase MTR4-modulated nucleolar proteome. The depletion of MTR4 or inhibiting transcri...

mcponline.org
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Shouhong Guang@WRnai
21 Apr 2025
Nuage in color: Systematic protein tagging shows the compositional complexity of germ granules: Developmental Cell cell.com/developmental-cell/…
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Shouhong Guang@WRnai
14 Apr 2025
The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters biorxiv.org/content/10.1101/…

The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA...

Metazoans utilize the small RNA pathway to regulate gene expression and maintain genome integrity. This pathway directs histone H3 lysine 9 tri-methylation (H3K9me3) or histone H3 lysine 27 tri-met...

biorxiv.org
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Shouhong Guang@WRnai
14 Apr 2025
The transcription machinery of piRNAs in worms and flies are quite similar. Both of them need an epigenetic reader and somehow recruits special transcription factor. worms: USTC -> UAD-2 -> TAF-12 flies: (kipferl)-> Rhino ->RDC -> moonshiner
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Happy Chinese New Year.
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Shouhong Guang@WRnai
14 Jan 2025
Peri-centrosomal localization of small interfering RNAs in <?A3B2 pi6?><italic>C</italic>. <italic>elegans</italic> sciengine.com/SCLS/doi/10.10… via @https://www.sciengine.com

Peri-centrosomal localization of small interfering RNAs in C. elegans

The centrosome is the microtubule-organizing center and a crucial part of cell division. Centrosomal RNAs (cnRNAs) have been reported to enable precise spatiotemporal control of gene expression...

sciengine.com
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Shouhong Guang@WRnai
14 Jan 2025
NRDE-3 formed peri-centrosomal foci neighboring the tubulin protein TBB-2, other centriole proteins and pericentriolar material (PCM) components in C. elegans embryos.
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The discovery of tiny RNAs that have crucial roles sciengine.com/SCLS/doi/10.10… via @https://www.sciengine.com
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