William Kaelin’s lab of @DanaFarber and @HHMINEWS and @harvardmed. We love hypoxia, tumor suppressor proteins, up-assays, and most of all controls.
Joined February 2019
- Tweets 201
- Following 116
- Followers 5,674
- Likes 1,076
55 Photos and videos
KaelinLab retweeted
Jun 12
JUST IN: @US_FDA approves combo HIF2 inhibitor Belzutifan PD1 inhibitor Pembrolizumab in adjuvant Kidney Cancer. Approval based on LS022 trial co-led with @tompowles1 presented @ASCO #GU26 adding another approval to @NobelPrize story with @kaelin_lab @DanaFarber @DanaFarber_GU !
Onward ! Great day for patients !
#HIF2 #oncology #labubu
dailynews.ascopubs.org/do/li…
blog.dana-farber.org/insight…
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Apr 19
Check out our group's recent collaborative effort focused on KDM6 enzymes in IDH mutant gliomas! Great work from all involved! biorxiv.org/content/10.64898…
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KaelinLab retweeted
28 Nov 2025
Our paper is now officially published in @NatureMedicine!
Thrilled to share the final version online: nature.com/articles/s41591-0…
Thankful to my co-authors, collaborators, and our lab for the support.
@kaelin_lab @DrChoueiri @PitarresiLab @namude @DanaFarber
12 Sep 2025
Excited to share our new preprint—the main project of my postdoc in the Kaelin lab! Blocking HIF2 doesn’t just slow tumors—it can reverse cachexia and hypercalcemia in kidney cancer. In the OSRC-2 model, HIF2 inhibition restored weight, preserved fat/muscle, and rescued survival.
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KaelinLab retweeted
10 Oct 2025
The @DanaFarber State of the Institute was a very special event ! Sharing the stage with CEO Ben Ebert, MD, PhD @NobelPrize Laureate William (Bill) Kaelin, Jr MD was special. We discussed the drug journey from Lab ->clinical trial-> approval, all with the #cancerpatient at the heart and center of all what we do!
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KaelinLab retweeted
12 Sep 2025
Excited to share our new preprint—the main project of my postdoc in the Kaelin lab! Blocking HIF2 doesn’t just slow tumors—it can reverse cachexia and hypercalcemia in kidney cancer. In the OSRC-2 model, HIF2 inhibition restored weight, preserved fat/muscle, and rescued survival.
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28 Aug 2025
Thrilled to share our work to find natural products that inhibit β-catenin! This is the result of an amazing collaboration with @theNCI Natural Products Branch and shows the power of 'up' assays to find new and interesting molecules! biorxiv.org/content/10.1101/…
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12 Aug 2025
Join us for The Science of Childhood Cancer lecture series hosted by @StJudeResearch this Thursday, August 14 at 12 CT/1pm ET where Bill will be presenting The Von Hippel-Lindau tumor suppressor: insights into oxygen sensing, tumor immunity, and drugging the undruggable.
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KaelinLab retweeted
24 Jul 2025
From the July issue: Requirement for Cyclin D1 Underlies Cell Autonomous HIF2-Dependence in Kidney Cancer brnw.ch/21wUoBl
By @nitin_shirole89, @kaelin_lab, and colleagues at @DanaFarber
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22 Jul 2025
Congrats to @QinqinJiang88!! Go check out her and the team's work on ERVs and ccRCC
cell.com/cell/fulltext/S0092…
18 Jul 2025
Please join us in congratulating the recipients of the KCRS25 Merit Awards for Translational Research!
🏅 Dr. Qinqin Jiang, Dana-Farber Cancer Institute
🏅 Dr. Simsek Berkay, Massachusetts General Hospital
🏅 Doris Zheng, Memorial Sloan Kettering Cancer Center
#KCRS25 #AcceleratingCures
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KaelinLab retweeted
5 Jun 2025
In 2023, the @FDA approved belzutifan for certain kidney cancers –– thanks to years of work led by Nobel Prize recipient William G. Kaelin Jr., MD, @kaelin_lab. Now, @DrChoueiri, director of @DanaFarber_GU, and team are working to expand its clinical use. bit.ly/3GNeb9D
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20 May 2025
Two of our wonderful technicians are off to medical school this summer! Mathew and Nora were great members of the lab, we are proud of them both!
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15 Apr 2025
We had a great time celebrating the group's many accomplishments!
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4 Apr 2025
We report that Cyclin D1 is an important direct target of HIF2 that drives the proliferation of ccRCC. Our findings further support the notion of combining HIF2 and CDK4/6 inhibitors to enhance antitumor activities. Congrats to @nitin_shirole89 and the team!
4 Apr 2025
Now online in @CD_AACR: Requirement for Cyclin D1 Underlies Cell Autonomous HIF2-Dependence in Kidney Cancer - by @nitin_shirole89, @kaelin_lab, and colleagues doi.org/10.1158/2159-8290.CD… @DanaFarber
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KaelinLab retweeted
New study just out from @kaelin_lab in @CD_AACR elucidating more about the dependence of #kidneycancer tumor cells on HIF2, implicating Cyclin D1 activity in resistance mechanisms to HIF2-targeted therapy aacrjournals.org/cancerdisco…
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KaelinLab retweeted
28 Feb 2025
The latest collaboration led by the @kaelin_lab and #WuLab with @BraunMDPhD, #SteveCarr, #DerinKeskin @VanAllenLab @DanaFarber_GU @harvardmed @MIT @df_hcc in @CellCellPress: HIF-2, ERV, T cells, HLA, renal cell carcinoma, et al….
sciencedirect.com/science/ar…
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KaelinLab retweeted
28 Feb 2025
Study in @CellCellPress co-led by @DanaFarber’s William Kaelin, MD, and Catherine Wu, MD, suggests the immune system can mount an attack on cancer cells that, due to cancer-driving mutations, present fragments of endogenous retroviral proteins on their surface.
➡️ bit.ly/3Xq4rYC
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28 Feb 2025
We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy
cell.com/cell/fulltext/S0092…
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28 Feb 2025
All spearheaded by the very talented @Qinqin32734657, @BraunMDPhD, Karl Clauser (@BroadProteomics)!
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KaelinLab retweeted
11 Dec 2024
It’s Day 2 at @SABCSSanAntonio! Presentations by our @DFCI_BreastOnc faculty include olaparib for BRCA breast cancer, and #weightloss intervention. Don't miss the Keynote by Nobel laureate William Kaelin (@kaelin_lab).
See our full #SABCS24 schedule: bit.ly/3CVsIOH
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