Cancer Biologists @salkinstitute, single cell enthusiasts, working to end breast and pancreas cancers
Joined January 2020
- Tweets 28
- Following 82
- Followers 150
- Likes 3
18 Photos and videos
Geoff Wahl Lab retweeted
12 Aug 2020
Official Ad! Please join my laboratory!
vanderuniv.taleo.net/careers…
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Geoff Wahl Lab retweeted
19 Aug 2020
Our recent @AGA_Gastro article was just highlighted in @NatRevGastroHep nature.com/articles/s41575-0…
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18 May 2020
Another recent paper from Wahl lab on tuft cell formation in pancreatic injury! Check this out! Great job done by @RaziaNaeem and @DelgiornoKathy
23 Feb 2020
New Research: Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis frontiersin.org/articles/10.… #Physiology
18 May 2020
The Wahl lab @salkinstitute discovered a new mechanism for regulating #RAS activity and protein levels, which provides a novel therapeutic strategy for inhibiting and depleting oncogenic RAS proteins! Great work by @yaochengli and colleagues! @PNASNews pnas.org/content/early/2020/…
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18 May 2020
Understanding such mechanisms may help to identify therapeutic avenues to promote targeted depletion of RAS proteins, such improvements could greatly benefit a large number of patients with pancreatic and other cancers that depend on oncogenic activation of RAS proteins.
18 May 2020
5. High-affinity conventional PPI between RAS and RAS binders cause inhibition, which is mediated by an autophagosome-lysosome degradation pathway. Membrane targeted strong RAS binding proteins deplete K-, N-, and H-RAS proteins (check the details in the paper).
18 May 2020
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18 May 2020
4. MAFI-mediated RAS-RBD_R89L low-affinity interaction is not sufficient to inhibit RAS activity. Rather, high-affinity classic PPI between RAS and RBD is required to inhibit ERK phosphorylation. (p.s. Look his beautiful western blots!)
18 May 2020
3. RAS-RBD interaction was utilized to model conventional protein-protein interaction (PPI) and Membrane Association Facilitated Interaction (MAFI). Both PPI and MAFI could lead to luciferase fusion and activation.
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18 May 2020
2. Different RAS isoforms localize sufficiently close on membrane domains in cells to enable Membrane Association Faccilated Interactions (MAFI) at near-endogenous expression levels in cells.
18 May 2020
1. To accurately quantify protein-protein interaction, we improved the original split-luciferase assay (ReBiLC) by normalizing the luminescent signal to the amount of expressed 1/2luc fusion proteins. Named it ReBiL2.0!
Geoff Wahl Lab retweeted
14 Jan 2020
IF you are interested in #breast and/or #pancreas cancer, single cell methods, #development, microscopy, mouse models, etc..WE ARE LOOKING FOR YOU! Hiring Now. @WahlLabSalk
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14 Jan 2020
The Wahl lab tackles the enigmatic pancreatic tuft cell! Learn more about how tuft cells restrain cancer from our new preprint at BioRx! @DelgiornoKathy @NikkiLytle @manorlaboratory @sammy_wn @LeoAndrade1974 @_LynnFang @KenOliveLab biorxiv.org/content/10.1101/…
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14 Jan 2020
PGD2 synthase (Hpgds) is also expressed in human pancreas TCs!
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14 Jan 2020
The Wahl lab and @DelgiornoKathy are now exploring other mechanisms by which TCs inhibit tumorigenesis. Interested? the Wahl lab is hiring!
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14 Jan 2020
It's amazing what the @manorlaboratory can do with EM data
21 Dec 2019
@sammy_wn is sooo talented. Check out our newest 3-D rendering of a pancreatic tuft cell!
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