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WarrenLeeLab @WarrenLeeLab

Endothelial Biologist. ICU Physician and Scientist.

Joined October 2018
  • Tweets 105
  • Following 94
  • Followers 152
11 Photos and videos
WarrenLeeLab retweeted
ATVB: An AHA Journal@atvbahajournals
18 Sep 2024
Check out the latest #ATVBnet post by @Y45900496Yu ! ahajrnls.org/3MQveaL

ATVB_net: Article Commentary: Endothelial Cell LDL Transcytosis in Atherosclerosis

ahajournals.org
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Agree with @MireilleOuimet. Really enjoyed CLVS2024! Great science and camaraderie.
Mireille Ouimet@MireilleOuimet
30 Sep 2024
I had an incredible time at #CLVS 2024 in Blue Mountain! Outstanding scientific presentations, and it was so rewarding to reconnect with familiar faces and meet new friends. Already excited for the 2025 meeting in Saskatoon, the "Paris of the Prairies"😉! 📷Credit: @PatriciaLiaw
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Delighted that Erika Jang and Winnie Ho's latest work is out. LDL transcytosis across the endothelium is the first step in atherogenesis, typically involving caveolin-1 and SR-BI or ALK1. We describe a distinct route that uses LDLR and Rab27a in response to pM levels of IL-1b.
ATVB: An AHA Journal@atvbahajournals
6 Aug 2024
IL-1B accelerates atherosclerosis by inducing LDL transcytosis independently of caveolin-1. The pathway requires LDLR and Rab27a @WarrenLeeLab @TseWingWinnieHo ahajrnls.org/3Aefewc
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WarrenLeeLab retweeted
ATVB: An AHA Journal@atvbahajournals
6 Aug 2024
IL-1B accelerates atherosclerosis by inducing LDL transcytosis independently of caveolin-1. The pathway requires LDLR and Rab27a @WarrenLeeLab @TseWingWinnieHo ahajrnls.org/3Aefewc
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WarrenLeeLab retweeted
Circulation Research@CircRes
16 Jul 2024
Kothari et al found that large #HDL particles hinder #LDL endothelial #transcytosis. Read more about the implications for #CVD risk in type 1 #diabetes at ahajrnls.org/4636hBP @BornfeldtKarin @KanterJenny @warrenleelab @TseWingWinnieHo @wobbrockjo
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WarrenLeeLab retweeted
Greg Fairn@gfairn
12 Mar 2024
ApoAI/HDL binds and competes with LDL for SR-BI on endothelial cells, thereby partly reducing LDL transcytosis. Yet another way “good” cholesterol is beneficial. The last work from Karen Fung’s thesis and collaboration with my former neighbor @WarrenLeeLab
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WarrenLeeLab retweeted
Kathryn Howe@kat_howe
2 Feb 2024
Directional Endothelial Communication by Polarized Extracellular Vesicle Release | Circulation Research Congrats ⁦@SnehaRajuMD⁩ et al! Wonderful work from many labs ⁦@kat_howe⁩ ⁦@FishLab_UHN⁩ ⁦@AikawaElena⁩ ⁦@WarrenLeeLab⁩ ahajournals.org/doi/10.1161/…

Directional Endothelial Communication by Polarized Extracellular Vesicle Release | Circulation...

BACKGROUND: Extracellular vesicles (EVs) contain bioactive cargo including miRNAs and proteins that are released by cells during cell-cell communication. Endothelial cells (ECs) form the innermost...

ahajournals.org
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WarrenLeeLab retweeted
Pablo Corral MD
@drpablocorral
2 Jul 2023
☝️Must read 👉LDL Transcytosis by the Arterial Endothelium—Atherosclerosis by a Thousand Cuts? 😉Inflammation stimulates LDL transcytosis 🤔Identifying the function and mechanisms of LDL transcytosis may ultimately permit its therapeutic manipulation doi.org/10.1007/s11883-023-0…
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WarrenLeeLab retweeted
AJP-Lung Cellular and Molecular Physiology@AJPLung
28 Jun 2023
Today we feature a #ShortReport in our #ArticleinPress by Rajiv Sanwal et al. #Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in #LungInjury without impairing innate immunity: ow.ly/7jHo50OVYEG @iBESTResearch @UnityHealthTO @UofT
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Excited to share our work describing targeted transfection of injured lung. A huge effort by @RajivSanwal and collaborators. Over-expression of claudin-5 using ultrasound & microbubbles decreased vascular leakage w/o impairing innate immunity. journals.physiology.org/doi/… @AJPLung

Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung...

In acute lung injury, the lung endothelial barrier is compromised. Loss of endothelial barrier integrity occurs in association with decreased levels of the tight junction protein claudin-5. Restora...

journals.physiology.org
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Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles frontiersin.org/articles/10.…

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Duffy antigen receptor for chemokines (DARC) or ACKR1 is expressed on endothelial cells in tissue but the protein is lost when cells are cultured. Here we report how to induce endothelial ACKR1 and how it is regulated. Congrats to Xinying Guo and @KhNegar for figuring this out!
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Thanks to our terrific collaborators including @TorresVJ_Lab, @Kat_howe, @FishLab_UHN and Andras Kapus.
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WarrenLeeLab retweeted
Pharmaceutics MDPI@MDPIpharma
11 Dec 2022
#MDPIPharmaceutics "Plug and Pop: A 3D-Printed, Modular Platform for Drug Delivery Using Clinical Ultrasound and Microbubbles" by Kushal Joshi et al. Full paper at：mdpi.com/1999-4923/14/11/251…
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Lab picnic on the island. Fun but a bit chilly; maybe should have done it before the CIHR deadline...
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First in-person conference in over two years. The students did a great job representing the lab! @GordonConf
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WarrenLeeLab retweeted
Tessa Davis@TessaRDavis
12 Apr 2022
Of all the meeting platforms we've used over the last 2 years, Zoom is the one I love most. Most of us think we know Zoom inside out. But we don't. Here are 7 Zoom hacks you probably haven't heard of, but you'll be glad you now know. 🧵👇
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Grateful for the renewal of my Canada Research Chair. And especially thankful to my terrific students and techs who make research so much fun!
Unity Health Toronto@UnityHealthTO
20 Jan 2022
Three scientists at St. Michael’s Hospital have received prestigious research chair awards from @CIHR_IRSC and @CRC_CRC. Congratulations to Dr. @AndrewDPinto, Dr. @ATricco and Dr. @WarrenLeeLab! Read more: bit.ly/3AheDWl
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