@WilhelmssonLab profile picture
Wilhelmsson Lab @WilhelmssonLab

DNA and RNA labels. Fluorescence. FRET. Base analogues. Biophysical chemistry. Optical tweezers. Methods for oligonucleotide-based drugs.

Joined July 2020
  • Tweets 181
  • Following 225
  • Followers 428
15 Photos and videos
Happy to share that we have a paper out in JBC. Here we develop an adenine analogue for in vitro transcription fluorescence labelling. The labelled mRNA can then be used for cell uptake studies and protein expression. Great job by all co-authors! jbc.org/article/S0021-9258(2…

Expanding fluorescent base analogue labelling of long RNA by in vitro transcription

To track RNA inside living cells and to study its natural interactions and mechanisms is vital in RNA research and the development of RNA-based therapeutics. In this work, we show that the fluoresc...

jbc.org
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Accepted article published online today. Great work by Pauline Pfeiffer and the rest of the team! Here we follow nucleotides and cellular RNA inside live cells by metabolic labelling and FLIM. pubs.rsc.org/en/Content/Arti…

Monitoring nucleoside metabolism in living cells with a nucleobase analogue via fluorescence...

To overcome challenges in fluorescence labelling of RNA inside living cells we have recently introduced a direct approach using the fluorescent nucleobase analogue 2CNqA. Here we demonstrate its...

pubs.rsc.org
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Slowly changing to Bluesky. Search for and follow wilhelmssonlab there I will most likely 😀 follow you back.
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Very happy to share the latest work from my and @FWesterlund's labs just published in @NAR_Open where we study the details of S-DNA. Great job especially by Vinoth Sundar Rajan. academic.oup.com/nar/advance…

Force-induced melting and S-DNA pathways for DNA overstretching exhibit distinct kinetics

Abstract. It is widely appreciated that double stranded DNA (dsDNA) is subjected to strong and dynamic mechanical forces in cells. Under increasing tension

academic.oup.com
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Wilhelmsson Lab retweeted
Stephanie Kath-Schorr@kath_lab
21 Nov 2024
Back from an exciting visit to Gothenburg @chalmersuniv discussing projects with Marcus @WilhelmssonLab and Fredrik @FWesterlund. Stay tuned for our PhD position offers in the MSCA doctoral network MeChaNiSM! 🎉🧬chalmers.se/en/projects/mech… #nucleicacids #chemicalbiology
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Kicking off EU doctoral network Mechanism in Gothenburg this week. Looking forward to working together!
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Wilhelmsson Lab retweeted
4for2@4for2pathfinder
5 Oct 2024
Are you a spectroscopist passionate about science and eager for new challenges? We have an open PostDoc position open at Chalmers under the supervision of Joakim Andréasson. Don’t miss this opportunity! More details in the following link: chalmers.se/en/about-chalmer…

Vacancies

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Less than two weeks left to apply for these positions with Fredrik Höök’s and my group:   web103.reachmee.com/ext/I003…
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Looking forward to this one where I will present my group's work as an invited academic speaker: mrnabased-therapeutics-europ…

5th mRNA-Based Therapeutics Summit Europe | January 2027

5th mRNA-Based Therapeutics Summit Europe | January 2027

mrnabased-therapeutics-europe.com
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Now not only as asap in @NAR_Open! Happy about this one! Our metobolic fluorescence labeling of RNA in non-engineered cell: track.smtpsendmail.com/90321…

Metabolic RNA labeling in non-engineered cells following spontaneous uptake of fluorescent nucleo...

Abstract. RNA and its building blocks play central roles in biology and have become increasingly important as therapeutic agents and targets. Hence, probin

academic.oup.com
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Wilhelmsson Lab retweeted
Martin Rahm@rahmlab
15 Sep 2024
#Chemicalbonding enthusiasts! Here is a chance to join us as a #postdoc and help develop the next-gen of electronic structure analysis AND apply it to study the optical effects of modified base-pair binding to DNA! #chempostdoc @PostdocO @CBOND2024 chalmers.se/en/about-chalmer…

Vacancies

chalmers.se
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MAF (Methods and applications in fluorescence) in Valencia is over. Great meeting! See you all next year in Montreal!
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Happy to soon kick off this EU project with @FWesterlund. chalmers.se/en/current/news/…

Chalmers leads EU-initiative on future medicines

RNA-based drugs hold immense potential and are of great interest to both society and the pharmaceutical industry. However, to tackle the current challenges, there is a need for increased knowledge...

chalmers.se
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Is metabolic fluorescence labeling of RNA in non-engineered cells possible? Yes it is! Very happy about this one: doi.org/10.1093/nar/gkae722 @OUPAcademic

Metabolic RNA labeling in non-engineered cells following spontaneous uptake of fluorescent nucleo...

Abstract. RNA and its building blocks play central roles in biology and have become increasingly important as therapeutic agents and targets. Hence, probin

academic.oup.com
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FB3 conference #5, a conference series Yitzhak Tor and I founded more than 10 years ago now, is over. Amazing event organized by the local committee here in Hong Kong! Thanks for being outstanding hosts! See you in Torino in 2026!
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Was celebrated by Chalmers yesterday for being employed for 25 years. Very nice evening!
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Happy to share this study from our lab and @AstraZenecaSE that was accepted and also published online today! chemistry-europe.onlinelibra…

Synthesis and Photophysical Characterization of a pH‐Sensitive Quadracyclic Uridine (qU) Analogue

Herein, we present the synthesis and detailed photophysical characterization of qU – a novel fluorescent base analogue of uridine. qU exhibits interesting properties such as excitation in the...

chemistry-europe.onlinelibrary.wiley.com
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Wilhelmsson Lab retweeted
Nanoscale journal family@nanoscale_rsc
5 Jan 2024
ICYMI! @FWesterlund, @WilhelmssonLab and co-workers' latest Nanoscale article exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues is out now! Read it it full at 👇 pubs.rsc.org/en/Content/Arti…

Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers...

The parasitic nature of the SARS-CoV-2 virus demands selective packaging of its RNA genome (gRNA) from the abundance of other nucleic acids present in infected cells. Despite increasing evidence that...

pubs.rsc.org
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Wilhelmsson Lab retweeted
Aishe Sarshad@SarshadLab
21 Dec 2023
I am recruiting a postdoc! Read more here: nature.com/naturecareers/job…

Postdoctoral fellow to study RNA binding proteins - Gothenburg (Stad), Västra Götaland (SE)

Type of employment: Postdoctoral researcher on stipend, 2 years  Extent: 100%  Location: University of Gothenburg, Sweden   First day of employment...

nature.com
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Happy to have our article published online in Nanoscale. We have used optical tweezers to study the structure and dynamics of the parts of the SARS CoV-2 genome that are involved in the initial steps of the virus particle assembly. Check it out! pubs.rsc.org/en/Content/Arti…

Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers...

The parasitic nature of the SARS-CoV-2 virus demands selective packaging of its RNA genome (gRNA) from the abundance of other nucleic acids present in infected cells. Despite increasing evidence that...

pubs.rsc.org
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