Postdoc at Shendure lab | PhD at Sfeir lab | mitochondrial DNA & more
Joined January 2011
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Yi Fu retweeted
27 Aug 2025
I'm thrilled to share our work from @JswLab (sciencedirect.com/science/ar…). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.
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Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells and our exploration of how cellular metabolism and transcription respond to deletion heteroplasmy. biorxiv.org/content/10.1101/… 1/19
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This work is a collaborative effort between our lab (@TKavlashvili @edebitet Toby), and @themaxland from @dana_peer lab and SAIL team, Ruobing and Keun from Craig Thompson lab, and @minsoo_kim1 from @EdReznik lab, whom I enjoyed working with and have learned so much from! 18/19
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I would also like to thank all other co-authors Roshan, @ChaligneRonan, Ignas, Rahul, Meril, Daphne, and @MarcoTigano for your generous help! Last but not least, none of this will be possible without @AgnelSfeir support and guidance along the way. 19/19
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