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The Yttri Lab @YttriLab

Interrogating the functional interactions of motor and decision circuits that lead to behavior. (he/lab - not official)

Joined October 2018
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  • Followers 1,694
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The Yttri Lab@YttriLab
Feb 12
A fun article about our work and the Olympics. There's some interesting relationships between skiing and basal ganglia function @CmuScience @ahmari_lab @BarbShinn theconversation.com/hesitati…

Hesitation is costly in sports but essential to life – neuroscientists identified its brain...

There are specific parts of the brain that trigger hesitation in times of uncertainty.

theconversation.com
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super excited to be giving a talk today at University of Bordeaux. thank you Nicolas Mallet for the invitation!!!
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and super cool neurocampus building!
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I am so curious and fascinated to find out what the heck this is
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Here's the tweetprint on pain, blocking its affective content, and its effect on behavioral and neural dynamics!
⚡️GREG_CORDER⚡️
@FlyBottleEscape
Jan 8
🧠⚡️💊New @Nature publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s41586-0… @PennMedicine
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Hot off the @Nature press! A-SOiD behavior library developed specifically for pain studies quantifies a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties @FlyBottleEscape @CmuScience @cmuneurosci nature.com/articles/s41586-0…

Mimicking opioid analgesia in cortical pain circuits

Nature - The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic...

nature.com
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I'll let Greg do the tweetprint, but he led a Phenomenal interdisciplinary team effort. Great science in every way. It's open too! Also part of the paper, you can build your own behavior rig with full analysis software for a tenth the price of commercial. Inquire if interested
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ok. 2 cool science summaries: 1)we discovered clear, discrete pain states - not just behaviors 2)no-pain and treated-pain were not the same, in part due to intervention targeting just the affective side, not numbing everything. Also kinda makes sense in my personal experience?
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So proud of @MattGeramita and his stellar work on striatal dynamics, decisions, and impulsivity. Pertinent for thinking about prob vs deterministic frameworks too. Also, suggests indirect may be doing more(cognitive?) than just opposing direct pathway nature.com/articles/s41593-0…
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Come see Paul present his very cool data analysis today at 1pm @SfNtweets
Paul Middlebrooks@pgmid
16 Nov 2025
If you're at SfN, stop by my teeny tiny nano talk Sunday at 1: "Neural population dynamics during naturalistic versus task-related behavior" w/ @YttriLab @Markolas11 @adenoeagle NANO017.01
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Huh, it's been 8 months since I was on here. Better late than never. I hope this new-ish paper will challenge people to think about the interpretations of our models STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!) cell.com/cell-reports/fullte… @CmuScience @cmuneurosci
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When applied contra, ipsi, or bilaterally to left turns, the effect was the same: D1/D2 stim biased mice to turn left more often, regardless of the side of stim. Note, bias is incomplete and did not induce an action, consistent with learning but not action selection
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SPNs are briefly active only for specific events. When driven randomly or for long dur, interpretation is hard. SPN attenuate response to light after a few secs (and Bstem response?) These results indicate STR's role in policy-based RL are at odds with basic action selection
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excited to be giving a talk @ UPenn today, with invite from @Fuccillomarc and @FlyBottleEscape A preview of my first slide....
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I'm revamping a masters-level Systems Neuro course this spring. Please HMU with your favorite reviews and perspective pieces! Extra points for approachable and/or thought-provoking. Any topic is welcome! I might end up biasing to the BME-heavy audience
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I'm still chewing through this one, but I think it's a keeper cell.com/trends/neuroscience…

The locus coeruleus as a global model failure system

Predictive processing models posit that brains constantly attempt to predict their sensory inputs. Prediction errors signal when these predictions are incorrect and are thought to be instructive...

cell.com
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Super exciting work and possibilities discussed today in the Brain Behavior Quantification and Sync consortium kickoff today!!! Great job to all (and got nerves for a talk for the first time in a while!)
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