🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588-024-0… 🧵👇

🫁 What if lung cancer metastases are not just destinations, but active sources of further spread? A new Nature study from TRACERx–PEACE offers one of the most detailed evolutionary maps of NSCLC metastasis to date. Using 501 longitudinally collected primary and metastatic tumor samples from 24 patients, researchers reconstructed how lung cancer spread from diagnosis to death, and the findings challenge the simple “primary tumor → metastasis” model. Key signals: 🧬 62.5% of patients had multiple primary tumor subclones that seeded distinct metastases 🔁 60% of sampled metastases were seeded by other metastases ⏳ Metastases present for longer were more likely to seed further disease 📍 Most metastatic migrations stayed within the same anatomical cavity ⚠️ Subclones that escaped the thorax were enriched for chromosomal instability The message is clear: metastatic NSCLC is not static. It is spatially organized, genetically diverse, and continuously evolving. This study does not immediately change clinical practice, but it gives a powerful biological rationale for better relapse monitoring, deeper metastatic profiling, and carefully selected local treatment strategies. oncodaily.com/oncolibrary/lu… @SonyaHessey @AMIHuebner @HaaseKerstin @KristianaGrigo4 @wingkinliu @ojlucas @FVasilopoulou @ProfSiowMingLee @DionysisPastos @MatthewGKrebs @LeQuesneLab @dean_fennell @crispinhiley @ZaccaSimo @NickyMcGranahan @CharlesSwanton #LungCancer #NSCLC #TRACERx #PEACEStudy #Metastasis #CancerEvolution #TumorHeterogeneity #ChromosomalInstability #PrecisionOncology #ThoracicOncology #OncoDaily #OncoDailyLung

🚨 Huge honour to have helped supervise this landmark PEACE study! New insights into metastasis a unique dataset of unprecedented resolution on metastatic evolution and dissemination that we hope will drive future advances 🙏 @CR_UK @CRUKresearch. Please take a look 👇

Congratulations to @CharlesSwanton, Mariam Jamal-Hanjani and colleagues on their fascinating analysis of the evolution of lung cancer metastasis published in @Nature! nature.com/articles/s41586-0…

Very fortunate to work alongside a fantastic team: @abi_bunkum @HaaseKerstin @AMIHuebner @KristianaGrigo4 Cristina Naceur-Lombardelli steered by: Mariam Jamal-Hanjani @CharlesSwanton @NickyMcGranahan @ZaccaSimo

Using MACHINA from @benjraphael's lab to infer metastatic migration patterns, we found that NSCLC primaries had multiple seeding subclones more often than a single seeding subclone. 4/9

Through the integration of the #PEACE autopsy programme, which allows high breadth metastasis sampling, with the #TRACERx lung study, we collected and studied 501 primary and metastatic tumour samples from 24 patients with #NSCLC enrolled in the both studies. 2/9

Online here: nature.com/articles/s41586-0… Open access here: rdcu.be/ff6YJ Key supporters of this work are @CR_UK , @CRUKLungCentre , @UCLHresearch alongside many others

Excited to share our ‘Evolutionary characterization of #LungCancer metastasis’ in #TRACERx & #PEACE, published today in @Nature: a decade spanning effort led by the Jamal-Hanjani lab, @SwantonLab, @NickyMcGranahan & @ZaccaSimo at @uclcancer & @TheCrick. Link below

Happy to share our latest study @Nature , where we evaluate somatic evolution and the effect of treatment in normal tissue using duplex sequencing 1/n nature.com/articles/s41586-0…

Excited to share our latest study in @CELL @MDAndersonNews a new single cell DNA&RNA co-assay technology (wellDR-seq) used to study the interactions of DNA copy number and gene expression during breast cancer progression led by @KaileWang @RuiYejerry cell.com/cell/abstract/S0092…

We're hiring a sequencing technician for #TRACERx! Interested in cutting-edge genomic tech to understand cancer? 👉 tinyurl.com/myh4un9j #Genomics #CancerResearch Join our world-leading teams at @TheCrick & @uclcancer

🚨 We're hiring a sequencing technician in #TRACERx! Join world-leading teams at @TheCrick & @uclcancer, working at the forefront of cancer research. Interested in cutting-edge genomic tech to understand cancer? Apply now! 👉 ucl.ac.uk/work-at-ucl/search… #Genomics #CancerResearch

We're a month out from #ISMBECCB2025!  You can now access the abridged agenda, downloadable schedules, poster listings, and SciFinder search tool links directly from the homepage: iscb.org/ismbeccb2025/home Click the link you need, or use the Programme &  Agenda menu for more options!

Be a part of ISMB/ECCB 2025: Shape the future of computational biology. Attend in-person in Liverpool or virtually for live sessions, Q&A, and exclusive networking. Elevate your research at the forefront of bioinformatics!

Huge congratulations to @LucreziaPatruno from @CCG_UCL for being awarded one of the best abstract awards at AI in Oncology in Paris, we are so proud! Join ISMB to hear her full story on the next advances in call CNAs from single cell seq!