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Mike O'Donnell @_MikeOD_

@mike-od.bsky.social We study the behavioral effects of commensal microbes on the worm, C. elegans @MCDB_Yale. Join me! (he/him)

Joined January 2012
  • Tweets 533
  • Following 476
  • Followers 521
2 Photos and videos
I'm thrilled to share our new preprint, in which we've found that neurotransmitters can be chemically "marked" as a way to incorporate metabolic history - such as diet or life stage. biorxiv.org/content/10.1101/… Led by Porhathai "Un" Malaiwong, Allen Schroeder and Tia Brown. 🧵(1/6)

Nuclear receptor-neurotransmitter coupling links behavior to metabolic state

Animals must flexibly respond to environmental stimuli to survive, and optimal responses critically depend on the organism’s current needs. Many organisms have evolved both cell-intrinsic and...

biorxiv.org
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For the worm-types, the destination of the glucose-octopamine complex is CAN - whose function is essential but not well understood. CAN appears to have the capacity to release octopamine but not to make it itself, implying it acts like a neuron under certain circumstances. (5/6)
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We'd love to hear your thoughts! (6/6)
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Yale MCDB@MCDB_Yale
25 Oct 2024
MCDB at Yale is seeking to fill a tenured Associate/Full Professor position. Candidates with interest in investigating outstanding questions in biology at the organismal, cellular or molecular level are encourage to apply. Apply at buff.ly/3NG6uSQ

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Yale MCDB@MCDB_Yale
28 Oct 2024
EVENTS THIS WEEK! MONDAY MCDB Coffee Hour 3 PM | Stratford Lounge TUESDAY Bio Blitz 9 AM | YSB 352 WEDNESDAY Alison Sweeney Seminar 3:30 PM | Bass 305 THURSDAY MCDB Community Trick or Treat Noon | Starts in KT 307 FRIDAY Graduate RIP 1 PM | Bass 305
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Harry McNamara@h4rrymcnamara
18 Oct 2024
a personal update: in January, I'm moving to Yale to join @MCDB_Yale and to open my lab in the @WuTsaiYale Institute! We will investigate multicellular self-organization using synbio tools to read and write developmental signals in stem cell models. syndevbio.org/

McNamara Lab at Yale

Investigating multicellular self-organization.

syndevbio.org
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David Breslow lab@DavidBreslowLab
23 Sep 2024
Our work on PPP2R3C-MAP3K1 at centrosomes is now out in @CurrentBiology! authors.elsevier.com/a/1jpcA…. Now with more functional analyses (lethality of PPP2R3C KO or FOP KO is suppressed by MAP3K1 KO) and more beautiful U-ExM expansion microscopy by @Armanduuum and @CentrioleLab!

David Breslow lab@DavidBreslowLab
4 Apr 2024
Excited to share our preprint on a new centriolar kinase-phosphatase module, with fantastic U-ExM microscopy by @CentrioleLab and @Armanduuum! biorxiv.org/content/10.1101/… Here we studied Ppp2r3c, a PP2A phosphatase regulatory subunit and hit from our prior cilia CRISPR screen…
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Sarah R. Barger@Sarah_R_Barger
17 Sep 2024
Check out this beautiful work by my former lab mate @JakeCarrasquil1 in the @BahmanyarLab 👏 Includes many cool findings on how CTDNEP1 and binding partner NEP1R1 regulate lipid synthesis at the ER and nuclear envelope! ✨👇
American Society for Cell Biology@ASCBiology
13 Sep 2024
From MBoC Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage @bahmanyarlab doi.org/10.1091/mbc.E23-09-0…
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bioRxiv Neuroscience@biorxiv_neursci
10 Sep 2024
A three-dimensional immunofluorescence atlas of the brain of the hackled-orb weaver spider, Uloborus diversus. biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Brady Lab@bradylabs
4 Sep 2024
Postdoc position alert - in Alex Cantó-Pastor's NEW lab at Yale. While we will miss him greatly, a new postdoc will be sure to benefit from his mentorship and will get to participate in a very exciting project at the intersection of development and immunity. @acantopastor
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Sofia Sepúlveda J.@jacobson_sofia
1 May 2024
May is Ehlers-Danlos Syndromes & Hypermobility Spectrum Disorders Awareness Month! As a disabled PhD student I wanted to remind others that 1 in 6 people worldwide – experience disability, -and 80% of those people are considered to have an "invisible" disability!👩🏻‍🔬@TheEDSociety
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David Breslow lab@DavidBreslowLab
4 Apr 2024
Excited to share our preprint on a new centriolar kinase-phosphatase module, with fantastic U-ExM microscopy by @CentrioleLab and @Armanduuum! biorxiv.org/content/10.1101/… Here we studied Ppp2r3c, a PP2A phosphatase regulatory subunit and hit from our prior cilia CRISPR screen…

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

Centrosomes have critical roles in microtubule organization and in cell signaling.[1][1]–[8][2] However, the mechanisms that regulate centrosome function are not fully defined, and thus how defects...

biorxiv.org
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Buelow Lab@BuelowLab
26 Mar 2024
Hesitating whether to attend? Don’t!! Register and join the friendly C. elegans Neuro Community in Madison, WI. Retweet if you can! conferences.union.wisc.edu/c…
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Siggy Nachtergaele@SiggyN5
21 Mar 2024
Thank you to @CellChemBiol for the opportunity to write this! It was fun to put to paper and maybe it'll resonate with some folks. Shoutouts to @StanfordBiochem @RohatgiLab and @UChiChemistry, and also my dad who can now cite a paper in which I say 'My father was right' 😆
Cell Chemical Biology@CellChemBiol
21 Mar 2024
Stories: Combating the myth of “innate genius” in science by Sigrid Nachtergaele @SiggyN5 at @MCDB_Yale @YaleCancer @YaleMed dlvr.it/T4QF2w
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bioRxiv Neuroscience@biorxiv_neursci
13 Mar 2024
Function of C. elegans neurons from synaptic connectivity biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Zoë Hilbert@zoehilbertspace
29 Feb 2024
Recruiting a research tech to join the growing Hilbert Lab @BiologyBC ! We're looking for curious scientists to help us build a supportive research environment and tackle adventurous new projects investigating host-fungal interactions. Apply: tinyurl.com/ev8bx7au Please RT!
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