CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments
abs:
arxiv.org/abs/2404.18021
Introduces CRISPR-GPT, a tailor-made LLM agent for automated designing of gene-editing experiments. Focuses on breaking experiment design down to a variety of substeps that the agents solve: selection of the CRISPR system, design of guide RNA, prediction of off-target effects, selection of delivery system, etc.
The agent was validated with human evals and even wet-lab experiments where 4 gene knockout experiments were designed with CRISPR-GPT with successful results.