Joined November 2017
- Tweets 267
- Following 768
- Followers 899
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Pinned Tweet
8 May 2024
A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!
nature.com/articles/s41586-0…
8 May 2024
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez
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Apr 16
4/2015: First day visiting Caltech
4/2026: Same spot, last day in Pasadena 11 years later!
Kudos to my mom for remembering this picture and wanting to recreate it. Moms know best :)
Also, she wants you to know she didn't age.
@uclacaltechmstp @Caltech @CaltechBBE
ALT Beckman Institute, Caltech, Pasadena, CA
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Mar 21
I matched to my #1 program at @UCSFPath in their Clinical Pathology/Physician Scientist Program!
Excited to meet my co-residents & colleagues! Kudos to @uclacaltechmstp, @mitchguttman, Zhen Mei, Dave Dawson and many others at @UCLA_Pathology for their support!
SF, here I come!
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Prashant Bhat retweeted
24 Jul 2025
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/ar…
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Prashant Bhat retweeted
2 Jul 2025
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s41586-0…
3 Oct 2024
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
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Prashant Bhat retweeted
10 Apr 2025
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s41586-0…
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Prashant Bhat retweeted
27 Nov 2024
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in @NatureGenet describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
nature.com/articles/s41588-0…
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19 Nov 2024
Hi! I’ll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link:
forms.gle/LopwGCc8RbuCqSu37
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Prashant Bhat retweeted
8 Nov 2024
I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1).
nature.com/articles/s41580-0…
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31 Oct 2024
Delighted to read this article by @TheScientistLLC featuring our work on nuclear speckles! Also features quotes from @mitchguttman and @belmont_andrew.
the-scientist.com/gene-proxi…
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31 Oct 2024
Elegant study by @ejkk0 & @daSpliceIsRight identifying 5'UTR intron sequences that enhance mRNA expression. Cool to see the integ. reporter higher Dox leading to greater intron-med. enhancement. Suggests a feedback loop between transcription & splicing to boost gene expression!
30 Oct 2024
My PhD work is live on bioRxiv today! :) biorxiv.org/content/10.1101/…
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7 Oct 2024
1st yr college (4/2011) Dr. Ambros visited Berkeley. His Cell 1993 paper was the 1st biology paper I ever read. After the talk, I asked for a picture; he looked around him when the organizer clarified,
"Victor, he is asking to take a picture *with* YOU!" 🥲
Congrats, Victor!🧬
ALT UC Berkeley April 7, 2011
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7 Oct 2024
And a big and hearty congratulations to Gary Ruvkun, too!
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Prashant Bhat retweeted
3 Oct 2024
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
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Prashant Bhat retweeted
30 Sep 2024
How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from our lab & @LafontaineLab Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) biorxiv.org/content/10.1101/…
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Prashant Bhat retweeted
27 Sep 2024
We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architectural non-coding RNA that recruits nuclear speckles proximal to viral genomic RNA.
biorxiv.org/content/10.1101/…
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Prashant Bhat retweeted
25 Sep 2024
Cheer on
@UCSFDeptofEM’s Kishan Patel, MD, as he competes on @CBS #Survivor47 in the Fiji islands! This ER doctor thrives in high-pressure situations. Tune in to see how he outwits and outlasts the competition. #UCSFProud
@UCSFHealth tiny.ucsf.edu/CvJpUD
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Prashant Bhat retweeted
21 May 2024
Now Online Splicing regulation through biomolecular condensates and membraneless organelles dlvr.it/T7Bmcw
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2 Jun 2024
It was fun to present at my first @RNASociety meeting in Edinburgh! Thanks to the organizers for a great meeting and the audience for the engaging questions! #RNA24
Want to chat about speckles and splicing in different cellular contexts, including disease processes? DM me!
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