Mapping RNA & DNA organization in the cell | Assistant Professor @HopkinsMedicine HHMI Hanna H. Gray Fellow | Postdoc @brangwynnelab | Ph.D. @mitchguttman 👩🔬
Joined July 2009
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Pinned Tweet
18 Feb 2021
So incredibly honored and thrilled to have been selected as a @HHMINews Hanna Gray Fellow! Huge thank you to so many – including my incredible mentors @brangwynnelab @mitchguttman and colleagues @Princeton @Caltech who I have been so lucky to work with! 🧬👩🔬
#HannaGrayFellows
18 Feb 2021
Today, HHMI is proud to announce the new #HannaGrayFellows, 21 early career researchers who are taking on some of the biggest challenges in the life sciences. bit.ly/3atgdcz
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Sofi Quinodoz retweeted
14 Jul 2025
Combining sequencing and imaging, @sofiquinodoz maps the spatiotemporal dynamics of rRNA processing, demonstrating how rRNA serves as both a scaffold and a substrate for the nucleolus—a multiphase, liquid-like structure. nature.com/articles/s41586-0… @brangwynnelab @omenndarlingbio
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Sofi Quinodoz retweeted
Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.
ALT The words "New tool allows researchers to track assembly of cells' protein-making machines, image by Holly Cheng" with microscope image of pink and green globules
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Sofi Quinodoz retweeted
2 Jul 2025
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s41586-0…
3 Oct 2024
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
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Sofi Quinodoz retweeted
4 Oct 2024
It has been a wonderful journey uncovering the mysteries of the multiphase nucleolus🤯🤩! So lucky to drive this project together with amazing postdoc @sofiquinodoz @brangwynnelab, and awesome collaborators, utilizing genomics, imaging, engineered rDNA🧬, and modeling approaches.
3 Oct 2024
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
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3 Oct 2024
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
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3 Oct 2024
(12) Together, we find that different rRNA processing steps are not only spatially organized in distinct nucleolar phases, but also play an active role in building and arranging the nucleolar phases that serve as processing compartments.
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3 Oct 2024
Also thanks to @SuperSciJew @DrJorine @danielswlee for initial inspiration/discussions for 5eU imaging to measure rRNA flux, and @mitchguttman @_prashantbhat for initial advice/protocols with 5eU-seq 🙏! Along with many others who helped with this work along the way!!
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Sofi Quinodoz retweeted
3 Oct 2024
Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating the lifecycle of RNA, the regulatory roles of RNA, the importance of RNA in disease, and the technologies used to study RNA. cell.com/molecular-cell/issu…
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Sofi Quinodoz retweeted
30 Sep 2024
How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from our lab & @LafontaineLab Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) biorxiv.org/content/10.1101/…
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9 May 2024
Congrats @_prashantbhat @mitchguttman ! Happy to have contributed to this project showing how genome organization around nuclear speckles impacts RNA splicing efficiency!
8 May 2024
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez
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