The model is quite simply a mess outside of coding DNA proximal zones around them. It's a really poor model of most of the tree of life except maybe compact genomes like viruses & bacteria. 3/

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During the first travel ban, we raised awareness through signatures, op-eds, and interviews. This time is much worse and I think we also need something more concrete: real stories and real data. I'm collecting accounts of how recent U.S. visa and immigration restrictions are affecting Iranians, specifically students, scholars, scientists, clinicians, and their families. If this has affected you or someone you know, please share your experience here (and share this form with others): forms.gle/wAgLaFjHb8Fu15Pq8 Please do not include sensitive identifying details!

"The" whole civilization doesn't die simply because it is alive. It has contributed to many other civilizations and will continue to do so. Better days will come to the motherland #Iran 💚🤍❤️

It was a pleasure to highlight Barbadilla-Martínez et al. (Nature). A powerful example of how integrative approaches uncover layers of genome regulation, linking mechanism to function and opening paths toward disease insights. nature.com/articles/s41422-0…

Heartbreaking to see Iranian scientists and universities getting bombed every day. It used to be targeted assassination of nuclear scientists since 2007 (see the list en.wikipedia.org/wiki/Assass…) but it has expanded to other fields and their entire neighborhoods and departments.

Excited to present @broadinstitute with @yusufroohani - if you're in Boston (April 1st) please reach out! Yusuf will be sharing a vision for how AI-powered computational tools can deepen our understanding of cellular function and guide experimental design. I'll dive deeper into the models, e.g. @arcinstitute's STATE and Stack models, what we've learned since, and what we're excited about next. The seminar will be recorded broadinstitute.org/talks/spr…

Mr. President, respectfully please consider the impact on everyday Iranian people. Targeting infrastructure like power or water makes life much harder for civilians. Millions of families are simply trying to live their daily lives with dignity! 🙏 @POTUS

Check out a vetted Pytorch port of AlphaGenome by GenomicsxAI collaborative team. See QT thread (with links to code & blogpost). Various fine tuning modules tutorials coming next. Community building announcements coming soon as well. Follow blog for latest updates.

Must read paper 📝

I am so excited to see epigenetic editing (CRISPRoff) move forward as a new approach in medicine through this clinical trial. We hope to make a difference for folks with HBV. Congratulations on a big step forward to all who made this possible! nchromabio.com/press-release…

AlphaGenome is out in @nature today along with model weights! 🧬 📄 Paper: nature.com/articles/s41586-0… 💻 Weights: github.com/google-deepmind/a… Getting here wasn’t a straight path. We sat down @googledeepmind to discuss the story behind the model, paper & API: youtu.be/V8lhUqKqzUc

I like to thank the teachers in Ukraine schools! Not many people can clearly distinguish the facts and describe it this clearly, including many of my Iranian friends. It's always helpful to keep our hearts open to learn from each other around the world on the fight for freedom.

Our Co-founder and CTO, Ali Lashkaripour, will be presenting at the Microfluidics Consortium 2026 in San Francisco on January 22nd. If you're attending, we’d love to connect!

Truth is painful. Although hope is necessary but wishful thinking never solved any problem and that seems like what @PahlaviReza is walking us through. I wish we are not buying fake hopes in a Trump shit show that would only result in more innocent lives taken by the regime.

I am an Iranian university professor. I was in Iran until last week and directly witnessed the uprising of the Iranian people. What is happening is a revolution born of desperation and courage. I fully and unequivocally endorse the speeches of Masih Alinejad and Ahmad Batebi at the UNSC. Every claim made by the Iranian regime—including by its foreign minister and its UN ambassador—is nothing but deliberate, systematic lies meant to cover up crimes. The regime has already killed my friend Parsa Saffar, a brilliant medical student at Mashhad University. Was he a terrorist? His only “crime” was being young, educated, and Iranian. The regime has filled the country with thousands of body bags. Were they terrorists too? How unarmed protesters, many of which being very young students can be terrorists? Why the so called "terrorists" that the Iranian regime claims only kill protesters, and not the rally of regime supporters? Understanding Iran is painfully simple. Iran possesses some of the world’s largest oil, gas, and natural reserves, yet the Islamic Republic has driven the country into collapse: one of the weakest economies in the region, the least-valued currency in the world, crushing inflation, families unable to afford food or rent, massive unemployment, and millions of young people unable to marry or build a future because of economic despair. The people are angry—and rightly so. The Islamic Republic has turned Iran into a deadlock through aggression, corruption, killing its own citizens, silencing all free voices, and enforcing internet blackouts to hide its brutality. The Iranian people are demanding regime change—just as people did during the Arab Spring in Syria. The same cruel regime that sent forces to help Bashar al-Assad massacre Syrians is now using the same methods to massacre Iranians. I call on the United Nations, the UN Security Council, and every single government to end their silence in the face of the Islamic Republic’s murder machine. A regime that massacres its own citizens has no red lines—and will not hesitate to kill the citizens of other countries as well. Act now. Stand with the Iranian protesters. End this brutal regime. #IranMassacre #IranRevolution2026 #DigitalBlackoutIran

جنایت جمهوری اسلامی در کشتار بی‌رحمانه‌ی مردم #فردیس کرج، که در پاسخ به فراخوان شاهزاده رضا پهلوی به خیابان‌ها آمده بودند، هیچ مجازاتی ندارد مگر سرنگونی این رژیم خون‌خوار و محاکمه‌ی سران حکومت و عاملان این جنایت.

Generative Inverse Design of RNA Structure and Function with gRNAde 1. A novel study introduces gRNAde, a high-throughput AI pipeline for designing RNA molecules with bespoke 3D structures and functions. This pipeline leverages deep learning to generate RNA sequences that can fold into complex structures, including challenging pseudoknots, matching the success rates of human experts in a community-wide competition. 2. gRNAde integrates a structure-conditioned RNA language model with computational screening to efficiently identify optimal RNA sequences. It demonstrated superior performance in designing functional RNA polymerase ribozymes, discovering highly active variants with up to 20% sequence divergence from the wild type, which were previously inaccessible through rational design or directed evolution. 3. The study highlights gRNAde’s ability to perform large-scale generative “jumps” in sequence space, identifying functional RNA variants far beyond the reach of conventional methods. This capability significantly accelerates the exploration of RNA sequence space and paves the way for fully programmable RNA catalysts. 4. gRNAde’s success in both structural and functional RNA design underscores its potential to revolutionize RNA engineering. The pipeline is open-source, enabling broader community use and further advancements in synthetic biology and biotechnology. 📜Paper: biorxiv.org/content/10.1101/… #RNAEngineering #DeepLearning #SyntheticBiology #Biotechnology #RNADesign