DVM, PhD. Study Director | Preclinical Toxicologist at Merck Healthcare KGaA
Joined January 2021
- Tweets 25
- Following 279
- Followers 56
- Likes 205
1 Photos and videos
Alessandro Sammarco retweeted
20 Oct 2024
👏Congratulations to our #EANO2024 award winners for Best Poster Presentation: Sophie Bockel (Clinical research), Alicia Buck (Basic research), Alessandro Sammarco (Translational research), Cressida Lorimer (Supportive care & quality of life research)! #NeuroOncology #btsm
6
16
2,513
Off to Glasgow for #EANO2024. Excited to present some of our work on lipid metabolism in #braintumors. Also proud of @ale__samma , who was selected to present his work on breast cancer brain metastasis during the Poster Pitches Session @EANOassociation @MGH_RI @MGHNeurology
2
14
677
29 May 2024
Excited to share our latest work where we tested the effect of a brain-penetrant clinical-stage inhibitor of fatty acid desaturation on cancer and immune cells in breast cancer brain metastasis mouse models. @BadRlab @katharinaeyme
biorxiv.org/content/10.1101/…
6
1
5
418
29 May 2024
These findings suggest that SCD inhibition could be an effective strategy to intrinsically reduce tumor growth and reprogram anti-tumor immunity in the brain microenvironment to treat BCBM.
1
68
29 May 2024
Pharmacological inhibition of SCD decreased engagement of immunosuppressive pathways, including the PD-1:PD-L1/PD-L2 and PVR/TIGIT axes in the tumor microenvironment.
1
56
29 May 2024
Inhibition of SCD enhanced antigen presentation by dendritic cells, was associated with a higher interferon signaling, increased the infiltration of cytotoxic T cells, and decreased the proportion of exhausted T cells and regulatory T cells in the tumor microenvironment.
1
49
29 May 2024
Combined targeting of SCD and PARP prolonged survival of mice with breast cancer brain metastases.
36
29 May 2024
Pharmacological inhibition of SCD markedly reshaped the lipidome of breast cancer cells and resulted in endoplasmic reticulum stress, DNA damage, loss of DNA damage repair, and cytotoxicity.
1
40
27 Feb 2024
I've decided to join the TEXAS MS 150, a fundraising 150-mile bike ride that changes the world for people affected by Multiple Sclerosis.
If you'd like to donate, in the first comment you'll find a link to my fundraising webpage. Thank you for your support!
1
72
27 Feb 2024
22
Alessandro Sammarco retweeted
25 May 2023
#GBM are lethal, molecularly heterogeneous tumors – it was unknown whether this molecular diversity led to distinct phenotypes and metabolic lipidomic vulnerabilities. New, open access @Cancer_Cell paper: sciencedirect.com/science/ar…
2
20
77
11,792
It is so exciting to see our work highlighted in @NatRevDrugDisc
Drugging a metabolic vulnerability in glioblastoma nature.com/articles/d41573-0…
3
6
22
3,274
Alessandro Sammarco retweeted
20 Jan 2023
A compound that targets de novo lipid synthesis in #GliomaStemCells shrinks #glioblastoma tumors in mice, potentiates DNA-damaging agents, and can penetrate the blood-brain barrier.
Read more: scim.ag/1eG @katharinaeyme @BadRlab @ale_samma
5
28
3,173
19 Jan 2023
We are so thrilled to see our work published in @ScienceTM on a new therapeutic strategy that inhibits de novo lipid synthesis to treat glioblastoma. Thanks to @BadRlab, @katharinaeyme and co-authors. Also, many thanks to @AICF_nyc for their support.
Very excited to share our latest work now out in @ScienceTM on targeting #lipidmetabolism in #glioblastoma
Great team effort led by @katharinaeyme @ale__samma with other past/present lab members and our collaborators at @Yumanitytx and @UCLA
🧵👇
science.org/doi/10.1126/scit…
5
163
12 Apr 2022
Here is our latest work on #lipidmetabolism in #glioblastoma. Fascinating results on what drives sensitivity and resistance to fatty acid inhibitors in glioblastoma. @BadRlab @katharinaeyme
biorxiv.org/content/10.1101/…
2
5
Attending SNO? check out work from our group led by the outstanding @katharinaeyme
EXTH-23 - Preclinical efficacy of a targeted, brain penetrant inhibitor of fatty acid desaturation in glioblastoma cdmcd.co/q9Wgqg #sno2021 #BTSM
2
14
We are looking for a research techI/II to join our group @MGHNeurology @harvardmed @MGH_RI. If you are interested in brain tumor research feel free to reach out.
#MedTwitter #AcademicTwitter
More info 👇
1
7
12
We have an open post-doc position for a newly funded project in our lab. If you are interested in studying stress signaling and lipid metabolism in brain tumors let's talk.
More details👇👇
partners.taleo.net/careersec…
#MedTwitter #AcademicTwitter
@MGHNeurology @harvardmed @MGH_RI
2
7
16
UPDATE: If you are fully vaccinated against #COVID19, you can resume activities without wearing a mask or staying 6 feet apart, except where required by federal, state, local, tribal or territorial laws, incl. local business and workplace guidance. More: bit.ly/3btJaFU
8,999
19,420
42,661