@ashumich profile picture
Ashu Tripathi @ashumich

Director- UM Natural Products Discovery Core: Discovery of drug leads and alteration of their biosynthetic pathway is what I do but tweets are just emojis :-)

Joined September 2009
  • Tweets 886
  • Following 427
  • Followers 881
53 Photos and videos
Ashu Tripathi retweeted
UMLifeSciences
@UMLifeSciences
30 Oct 2025
The U-M Natural Products Discovery Core's pitch video for developing a rapid-response system for agricultural biodefense has been deemed Awardable by the @DARPA ERIS Marketplace. Government customers can view the 7-minute video solution on ERIS: darpaconnect.us/eris. “We are excited about the opportunities that this recognition on the DARPA ERIS Marketplace opens, and eager to help transform agricultural defense from reactive to proactive,” says NPDC Director @ashumich .
DARPA Awardable badge with text: The University of Michigan's Natural Products Discovery Core has achieved "Awardable" status through the DARPA ERIS Marketplace for its proposal to develop AI-accelerated microbial countermeasures against agricultural threats."

ALT DARPA Awardable badge with text: The University of Michigan's Natural Products Discovery Core has achieved "Awardable" status through the DARPA ERIS Marketplace for its proposal to develop AI-accelerated microbial countermeasures against agricultural threats."
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Please help with this fundraiser. Your donation will make a meaningful difference in advancing STEM education for elementary/middle school students. We are deeply grateful for your commitment to inspiring the next generation of scientists and innovators. gofund.me/4467a03e

Donate to Support South Arbor Science Olympiad Team!, organized by Julia Levin

Support South Arbor Charter Academy Science Olympiad Teams! A new school year … Julia Levin needs your support for Support South Arbor Science Olympiad Team!

gofundme.com
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Ashu Tripathi retweeted
Gary Siuzdak@kadzuis
10 Apr 2025
Recent Beamish award winner @TaoThuan @NatMetabolism @UBC describes how to avoid “nonsensical” results in metabolomics doi.org/10.1038/s42255-025-0…

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics

Nature Metabolism - Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites...

nature.com
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A very well deserved professorship!
U-M College of Pharmacy@UMichPharmacy
31 Mar 2025
Congratulations to Dr. Amanda Garner, who has been named Charles Walgreen, Jr. Professor of Medicinal Chemistry. This named professorship recognizes Dr. Garner's dedication to science, education and mentorship. Read the full release: bit.ly/4c4k4La
Portrait of Amanda Garner, PhD, a Professor of Medicinal Chemistry, smiling in an office setting.

ALT Portrait of Amanda Garner, PhD, a Professor of Medicinal Chemistry, smiling in an office setting.
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Beautiful study!
Zhuo (Alex) Shang@ZhuoAlexShang1
19 Mar 2025
Thrilled to share our discovery of a novel polyene macrolide antifungal with a unique mechanism of action—targeting fungal membrane phospholipids. Grateful for the collaboration with Prof. Zongqiang Wang’s team at CPU. Check out our paper in @Nature: nature.com/articles/s41586-0…
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Hopefully smart people can use some analytics into making funding decisions to NIH 🤷🏽 fiercebiotech.com/research/n…

NIH grants powered $94B in economic activity in 2024 and supported more than 400K jobs: report

Funding granted to researchers by the National Institutes of Health (NIH) powered $94.58 billion in economic activity across the U.S. | Funding granted to researchers by the National Institutes of...

fiercebiotech.com
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Ashu Tripathi retweeted
Vicki Ellingrod (she/her)@VEllingrod
9 Feb 2025
Impact of NIH funding for Michigan
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The @ScienceMagazine paper, "Efficient discovery of natural products through native strain metabolomics", highlights a cutting-edge approach combining metabolomics, genome mining, and mass spectrometry to unlock microbial chemical diversity. science.org/doi/10.1126/scie…

Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria

The transmission of antibiotic-resistance genes, comprising mobilization and relocation events, orchestrates the dissemination of antimicrobial resistance. Inspired by this evolutionarily successful...

science.org
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🌱 Exciting news for #NaturalProducts enthusiasts! The ACS Virtual Special Issue explores the latest breakthroughs in natural products & #MedicinalChemistry, shaping the future of #DrugDiscovery. Don't miss out on these cutting-edge insights!Read more: pubs.acs.org/page/vsi/natura…
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All the NP discovery resources put together effectively by @kate_duncan and team! actinobase.org/index.php?tit…
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Well .... that's some irony 😀 science.org/content/article/…

‘We are embarrassed’: Scientific rigor proponents retract paper on benefits of scientific rigor

Authors acknowledge “elemental errors” in a study showing ways to boost research replicability

science.org
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A top-down drug discovery (TD3) approach, starting with a massive digital search through a database of over 100,000 fully genomicized fungi to identify loci encoding molecules with a predetermined human target by #LifeMine pubs.acs.org/doi/10.1021/acs…

Genomic Discovery and Structure–Activity Exploration of a Novel Family of Enzyme-Activated Covalent...

Fungi have historically been the source of numerous important medicinal compounds, but full exploitation of their genetic potential for drug development has been hampered in traditional discovery...

pubs.acs.org
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Well..well! I am on Metformin for 11 yrs now, could have studied its impact on me. Never too late I guess 😀 cell.com/cell/abstract/S0092…

Metformin decelerates aging clock in male monkeys

Prolonged metformin treatment diminishes the multidimensional biological age and alleviates neuronal aging through the Nrf2 pathway in male primates.

cell.com
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Painstakingly create the BGC in chemdraw/bio render etc. or just use RAIChU by @marnixmedema? link.springer.com/article/10…

RAIChU: automating the visualisation of natural product biosynthesis

Journal of Cheminformatics - Natural products are molecules that fulfil a range of important ecological functions. Many natural products have been exploited for pharmaceutical and agricultural...

link.springer.com
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This is a terrific framework! nature.com/articles/s41597-0…

Digital Microbe: a genome-informed data integration framework for team science on emerging model...

Scientific Data - Digital Microbe: a genome-informed data integration framework for team science on emerging model organisms

nature.com
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Excited to announce our latest paper with #Burkartlab! We uncovered the cryptic cerulenin rearrangement in ketosynthase inhibition using advanced NMR & MS. A leap forward in drug development! pubs.acs.org/doi/full/10.102…

Cryptic Cerulenin Rearrangement in Ketosynthase Covalent Inhibition

The antibiotic cerulenin is a fungal natural product identified as a covalent inhibitor of ketosynthases within fatty acid and polyketide biosynthesis. Due to its selective and potent inhibitory...

pubs.acs.org
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Excited to share our collaborative study with #MohimaniGroup at @CarnegieMellon nature.com/articles/s41467-0…

Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining...

Nature Communications - Type 1 polyketides are a major class of natural products with diverse bioactivities but are mostly identified via bioactivity-guided purification which is limited to...

nature.com
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Congratulations @ColleenYancey for the great study! I am awaiting further exciting follow ups from @laurenhart_98
Lauren Hart@laurenhart_98
1 Jul 2024
Excited to see @ColleenYancey and I's (among many coauthors @GreatLakesGreg @davidhsumich @ashumich) joint effort out now! Spoiler alert that these bugs are capable of producing much more than microcystins... doi.org/10.1128/msystems.003…
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This what I call direct intervention in natural evolution 🤦🏻‍♂️ pbs.org/newshour/nation/u-s-…

U.S. officials plan to kill hundreds of thousands of barred owls to save another species from...

U.S. wildlife officials are embracing a contentious plan to deploy trained shooters into dense West Coast forests to kill almost a half-million barred owls that are crowding out their smaller...

pbs.org
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SMIRC approach for potentially isolating novel natural products straight from nature. I would like to use the technique to figure out random chemicals spread across our vicinity. nature.com/articles/s41467-0…

Small molecule in situ resin capture provides a compound first approach to natural product discovery

Nature Communications - Environmental analyses predict extensive, yet to be realized natural product diversity. Herein, the authors report an approach that directly captures natural products from...

nature.com
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