Donāt miss Dr. Erica Mayer (@elmayermd) presenting results from a Phase II study on neoadjuvant niraparib with dostarlimab for patients with BRCA- or PALB2-mutated #BreastCancer, focusing on the ER /HER2- cohort, at the #SABCS24 Rapid Fire 3 session. @TheTBCRC
šļø Friday, December 13th
ā° 12:00 ā 12:50 pm CST (1:00 ā 1:50 pm EST)
š Hall 1
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Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) retweeted
#SABCS24
Dr. @awolff: Must study impact of new #cancer drugs on reproductive health.
āļø He believes we are under-utilizing ovarian suppression & over-utilizing chemo in premenopausal w/ #breastcancer, & window to answer this Q definitively in #bcsm#clinicaltrials is closing.
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Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) retweeted
Excited to see these @TheTBCRC presentations at SABCS 2024!
-TBCRC 052: Does margetuximab provide benefit over trastuzumab in neoadjuvant HER2 disease?
-TBCRC 056: neoadjuvant PARP IO in ER BRCA1/2 or PALB2 mut breast cancer?
- and more!
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Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) retweeted
It was a treat to do the Highlights of the Day I - Breast Ca Metastatic, and contextualize the great work of presenters and discussants. Thou shalt not forget to watch the fantastic talk by discussant @MayoClinic Dr. Ciara O'Sullivan.
Taking a moment to acknowledge that many places, especially in third world countries, lack access to essential drugs and resources. We are fortunate to have more in the US.
A shout out to Dr. OāSullivan for acknowledging that treatment paradigms are not applicable everywhere, we often take that for granted ā¼ļø
#HealthEquity#AccessToCare#ASCO24#bcsm@MayoCancerCare@ASCO@OncoAlert
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Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) retweeted
RxPONDER: AMH (low levels associated w/ diminished ovarian reserve) in women classified as premenopausal
If low AMH --> no benefit from adj chemo
If med/high AMH--> ā¬ļø4.4% in 5 yr DRFS w/ chemo
Suggests:chemo impact may be due to impact on ovarian fxn
@OncoAlert#ASCO24
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Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) retweeted
Dr. Nadine Tung discusses TBCRC048 at #ASCO24 - olaparib is effective in patients with MBC with inherited PALB2 mutation or tumor acquired BRCA1 or BRCA2 mutation. Benefit in initial trial confirmed in a larger group of patients @TheTBCRC@OncoAlert
So grateful, @TarahBallinger. We are privileged that you chose to bring your brilliance to @eaonc and brighten the work we do to improve care for our patients. @NCICancerCtrl#ASCO24
Tarah, your presentation was just fantastic, and your work a true testament to your passion, commitment and skill. I am honored to work with you. Canāt wait to see what you will do next!!
Tomorrow #ASCO24 check out @NTungMD present #TBCRC048 olaparib expanded cohorts of gPALB2 and sBRCA MBC, one of the most rewarding studies Iāve managed in the last decade and a testament to the power of investigator-initiated research @BIDMChealth@DFCI_BreastOnc@TheTBCRC
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Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) retweeted
TBCRC048 is a collaborative IST led by #DFHCC and was open at 11 academic centers across the US via @TheTBCRC - thank you to the incredibly dedicated study teams at each of the sites and, most importantly, the 114 participants, many of whom traveled great distances for the study
Tomorrow #ASCO24 check out @NTungMD present #TBCRC048 olaparib expanded cohorts of gPALB2 and sBRCA MBC, one of the most rewarding studies Iāve managed in the last decade and a testament to the power of investigator-initiated research @BIDMChealth@DFCI_BreastOnc@TheTBCRC
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Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) retweeted
As seen today at #ASCO24 - TBCRC026, HER2-E and tumors with increased immune signaling more likely to respond to HER2-directed therapy in ER-/HER2 breast cancer treated with neoadjuvant HP without chemo. @TheTBCRC@HennessyMaeve
TBCRC 049: Tucatinib, trastuzumab, capecitabine for HER2 LMD
-The first prospective LMD trial to show all of the following:
-therapeutic drug levels in CSF
-intracranial response
-improvement in symptoms and QoL
-extended OS compared to historical controls