Collaborative Drug Discovery Partners with Lilly TuneLab to Make Lilly AI/ML Models Available in CDD Vault collaborativedrug.com/cdd-bl…

Elon just created 4,400 millionaires in a single day. 400 of them are now worth over $100 million. These aren't VCs. They're SpaceX employees, and the list includes welders, technicians, and cafeteria staff, because for two decades the company paid every level of the workforce in stock instead of higher salaries. Juan Hernandez immigrated from Mexico and took a $28 an hour contractor welding job in 2015. He says he didn't even know what SpaceX was. The company gave him a $10,000 equity grant and let him buy more shares through payroll deductions. That stake is now worth $880,000. Trevor Hise's parents wanted him to take a stable job at General Electric. He picked SpaceX instead, stayed 12 years, and accumulated over 100,000 shares. At the $135 listing price that's $13.5 million. He's 37 and semiretired. His words: "The magnitude of this has been ridiculous." The most telling detail came before the listing. Over 100 employees quietly banded together and negotiated a group wealth management deal covering up to $5 billion, because none of them had ever needed a wealth manager before. Software IPOs have minted millionaires for 30 years. This is the first one where the money went to the factory floor.

Sinclair's new preprint provides the first direct experimental evidence for the Information Theory of Aging: your cells don't age because they break — they age because they forget who they are. The biological blueprint is still intact. The cells just stop reading it correctly. That distinction changes the entire target: you don't repair damage. You restore data. And data can be restored.

Ray Kurzweil predicts AI will change humanity completely by 2030. - We only have 6 years left of aging! - By 2032, we'll be able to go through all the different possibilities. So, you get back at least a year. As you go past 2032, you'll actually get back more than a year. But you won't die of aging at that point. - He gives an example: he has a pancreas that is actually external and generates insulin, and then he measures glucose. - He has always said that if you take care of yourself to get to this point, there will be tools and technology to keep you alive for a very, very long time and healthy. The future is very good for our health!

I’ve had a number of conversations with folks inside and outside government about the current situation with Anthropic, and here is what I believe to be true: — As we know, Anthropic publicly released its Mythos class models earlier this week under the commercial name Fable. — Fable is Mythos with guardrails. But if those guardrails fail, then you’ve exposed Mythos and its advanced cyber capabilities to people who shouldn’t have them. (Keep in mind that Anthropic itself widely promoted the idea that Mythos was a cyberweapon and needed to be regulated as such. They asked for government regulation of Mythos and championed the guardrails on Fable. If there is a vulnerability — big or small — it is Anthropic’s responsibility to patch.) — A highly credible trusted partner of both Anthropic and the USG who was testing Fable came forward with a jailbreak of those guardrails. The Admin asked Dario to fix the jailbreak or de-deploy the model. Dario refused. — In their blog post, Anthropic defended its decision by saying the jailbreak isn’t serious. That is not what the trusted partner and the USG believe; nor is that kind of minimizing language consistent with Anthropic’s brand as the AI safety company. It’s difficult to fathom how they could claim a jailbreak allowing operability of a cyber weapon could be defined as not “serious.” — In the past, Anthropic has always said that safety must be top priority and taken super seriously. In this case, Anthropic prioritized the continued offering of the consumer model over safety. — In reaction, the Admin issued the export control. The Admin did this reluctantly. It’s been very surprised that Anthropic hasn’t wanted to cooperate with a reasonable safety request (ie fixing the jailbreak issue). Anthropic’s reaction is very much at odds with their branding and ethos as a safe AI research community. — The Admin’s hope now is that Anthropic remediates the safety issue, the export control is lifted, and Fable goes back into general release. The Admin wants all of this to happen as soon as possible. It is frankly bewildered that Anthropic hasn’t wanted to comply with safety requests that it previously said were its highest priority. — Those trying to misdirect and tie this action to the prior DoW/Anthropic issues are wrong. The Admin values Anthropic’s technical capabilities and feels that this issue, while serious, should be easily resolved. The ball is in Anthropic’s court.

RT @DavidSolomon: Congratulations to SpaceX on today’s $75B IPO, the largest ever brought to market. Goldman Sachs is honored to have ser…

This is a big turning point for AI regulation. The government is starting to deem some models too powerful for certain uses, which creates a precedent for a range of possible controls in the future. I’m in the camp that this is unnecessary and we should be primarily regulating the use of AI, as opposed to the underlying models. But, equally, there are plenty of people that actually prefer this outcome. Either way, it’s unlikely that we’re going back to a world where the government doesn’t have far more meaningful involvement in the rate of AI progress.

This whole Fable export control situation is actually net positive to regulation discourse. It’s an early peek into what AI regulation would end up looking like at scale when enacted at the model layer instead of the specific application of the AI. The government would have sole discretion over when a model can be released to the to public, based on a bunch of factors that they inherently control. In this case, based on the available reporting, the risk is that the model can be jailbroken to deliver increased cyber exploit capabilities. The issue is that actually you want models to be able to have those capabilities on the defense side of cyber as well, and for all intents and purposes, by Anthropic’s own response, you can execute these capabilities today in other models. So thus the whole challenge will be that you’re debating with the government, over months and months, with every model release, what these models are actually capable of and what their risks are. Inherently, there’s not only a lot of subjectivity in determining those risks, but there’s also many other factors that go into the risks being practical in the first place. The net result is that we would end up with backlog of AI releases, progress in the market inherently would dramatically slow down, and AI would start to look more like any other sclerotic industry. If this paradigm had existed 3 years ago at the start of the current AI wave, we’d likely currently be stuck on GPT-4 level intelligence at this point. This is why, wherever possible, we should be regulating the applied use of AI. We should continue to study and enforce the dangerous use of AI in cyber attacks, financial services risks, fraud, biowarfare, and other spaces. AI safety is incredibly important, but slowing down progress this early in the development of AI I suspect is net harmful.

What's new in biology? @salonium and I are back with the monthly roundup. Highlights include: 1. A permanent gene-editing therapy to lower cholesterol. 2. Promising data on a mRNA cancer vaccine for high-risk melanoma. 3. A functional cure for some patients with hepatitis B.

Efficient base editing and development in human embryos without chromosomal alterations | bioRxiv biorxiv.org/content/10.64898…

Scientists Concerned Latest Gene Editing of Human Embryos Could "Open the Floodgates" futurism.com/health-medicine…

4 things to know about the newly approved sunscreen ingredient : NPR npr.org/2026/06/13/nx-s1-585…

SpaceX IPO: Live updates on everything you need to know | TechCrunch techcrunch.com/2026/06/12/sp…

The US government, citing national security authorities, has issued an export control directive to suspend all access to Fable 5 and Mythos 5 by any foreign national, whether inside or outside the United States, including foreign national Anthropic employees. The net effect of this order is that we must abruptly disable Fable 5 and Mythos 5 for all our customers to ensure compliance. Access to all other Claude models is not affected. We apologize for this disruption to our customers. We believe this is a misunderstanding and are working to restore access as soon as possible. Read our full statement: anthropic.com/news/fable-myt…

Elon Musk, the world's first trillionaire - his stratospheric rise in charts bbc.com/news/articles/c4gyp5…

SpaceX IPO: Stock Makes Public Trading Debut; Elon Musk Is Officially a Trillionaire; News and Analysis barrons.com/livecoverage/spa…

SpaceX (SPCX) IPO: Live updates cnbc.com/2026/06/12/spacex-i…

link to the series: boundlessvc.com/writing/ai-x…

CDD Vault and Kiin Bio Integrate to Streamline End-to-End Drug Discovery Workflows collaborativedrug.com/cdd-bl…

every year @newlimit, we host friends at the lab & share our progress for 2026, we announced: - 2X increase in discovery rates with AI systems - new program for endothelial cells - 0 -> 1 medicines headed to the clinic - accelerating recovery from alcohol some highlights --

Today I'm publishing a new essay, Policy on the AI Exponential. AI is progressing extremely fast—much faster than the policy process was built to handle. The essay lays out where I think the technology is now, and the action needed to close the gap: darioamodei.com/post/policy-…