Understanding mucosal tissue dynamics
Joined November 2019
- Tweets 34
- Following 65
- Followers 238
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13 Photos and videos
May 13
🧵 It’s out 📑
What happens when Salmonella reaches the intestinal crypt, not just the surface epithelium, but the specialized cells that maintain and defend the tissue?
Our paper follows bacterial invasion at single-cell resolution
nature.com/articles/s41590-0…
@NatImmunol
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May 13
Beyond infection, this raises an important possibility:
ISC inflammasome activation may shape epithelial remodeling in chronic inflammatory and neoplastic contexts, including IBD and colorectal cancer.
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May 13
Read the full story here:
nature.com/articles/s41590-0…
@NatImmunol
Shout-out to the great team and our amazing collaborators who worked on this project over the years
@SachaLEBON @bitonm @matanhofree
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May 8
Excited to share our new @biorxivpreprint from the lab!
We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense.
biorxiv.org/content/10.64898…
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May 8
Our findings uncover a mechanism by which adult stem cells integrate environmental signals to maintain tissue homeostasis.
Congrats to @Aviya_HM and the whole Biton lab team!🎉🎉🎉
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Mar 21
Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
doi.org/10.64898/2026.03.18.…
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9 Jun 2025
Excited to share our latest preprint with @Sagi_Lab on @biorxivpreprint!
The ECM remembers inflammation—forming a scarred niche that reprograms stem cells and drives chronic disease.
The ECM isn't passive—it instructs.
🔗biorxiv.org/content/10.1101/…
#IBD #ECM #StemCells #Inflammation
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Biton Lab retweeted
Join us at #IUIS2025 in Vienna, Austria for an exciting plenary on Innate Immunity and Inflammation with speakers, Dr. Miriam Merad (@MiriamMerad, IUIS President) and Dr. Caetano Reis e Sousa (@ReiseSousaLab)!
Learn more and register at iuis2025.org!
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Biton Lab retweeted
16 Oct 2023
"In the face of darkness, let our voices be the guiding light". A clear message from the
@WeizmannScience
to our fellow scientists and friends. Thanks for being there for us, we will never forget 🙏📷 #StrongerTogether.
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24 Mar 2023
Excited to host Prof. Xavier w/ @BINAWIS1 ! His captivating lecture on Controllers of Barrier Defense and translational clinical research left us all feeling inspired and motivated. Amazing talk ! Thank you for sharing your expertise with us, Prof. Xavier ! @TheXavierLab
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23 Feb 2023
Very exciting h trip at #ILANIT2023 conference! Our team rocked the stage with talks from @bitonm, Vlad, and @SachaLEBON, while Carmel and @Aviya_HM wowed us with their poster presentations. So proud to be part of such a talented and innovative group! 🤩🎉👩🔬👨🔬📊📈
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Biton Lab retweeted
Can't end 2022 without some pictures from our IRB departmental retreat, right?
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