40 Product Podcasts for Product People bog-dan.medium.com/40-produc…

Avi Wigderson is the only person in history to have won both a Turing Award (computer science) and Abel Prize (math). I interviewed him all about his field. We discussed: • His intuition on a proof of P vs NP • Why we use SAT solvers for most NP problems • Zero knowledge proofs and their impact • Quantum computation and implications • Math and computer science's relationship Where to watch: • YouTube: youtu.be/5GUcvSAJcJw • Spotify: open.spotify.com/episode/4JZ… • Apple Podcasts: podcasts.apple.com/us/podcas… • Transcript: developing.dev/p/turing-awar… Thank you to this episode's sponsors for supporting my work: • WorkOS: makes your app Enterprise Ready with easy to use APIs to add SSO, SCIM, RBAC, and more in just a few lines of code, check them out at workos.com/ Timestamps: 00:00 - Intro 01:08 - P vs NP 14:51 - What if you relaxed correctness 25:38 - Why NP complete problems are equivalent 30:33 - Space vs time complexity 43:06 - Why people use SAT solvers 45:53 - Randomness is a resource 55:48 - Randomness depends on computational power 01:21:20 - Zero knowledge proofs and their significance 01:38:30 - Quantum computation and why it matters 01:56:24 - Math vs computer science 02:08:16 - Major breakthroughs and his experience 02:12:31 - Advice for his younger self 02:14:48 - Outro

You have ~40 working years to save for 85 years of retirement.

This has quietly been a miracle month in medicine. In the last 5 weeks we’ve got news on: - retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels - RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life - small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol - Mayo’s AI-assisted radiology showing vastly improved cancer detection - this new therapy for metastatic solid tumors This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

someone should make a coffee table book of the billboards of san francisco

Every year, I share this video of French caretakers who take sand from Omaha Beach in Normandy, and scrub them into the letters to give them the gold coloring. They do this for all 9,386 US soldiers who died. France also gave us this land as American soil. #MemorialDayWeekend

Big if no significant side effects.

Here's an actual Monet painting of someone looking at two paintings trying to determine which one was generated by a human and which by an automaton.

the future is a scam by big time to create more past

I’ve always believed the No.1 application of AI should be to improve human health. That work started with AlphaFold, and now at @IsomorphicLabs with the mission to reimagine drug discovery and one day solve all disease! We are turbocharging that goal with $2.1B in new funding.

A man with no working truck convinced Wall Street he had built the next Tesla. His company hit $30 BILLION. All he did was push it down a hill with no engine. > Trevor Milton founded Nikola in 2014, named after the same inventor as Tesla. > The goal was to build hydrogen powered trucks that would make diesel obsolete. He had no trucks. > In 2018 he released a promotional video called Nikola One In Motion. It showed a sleek semi truck accelerating smoothly down an open highway. Investors went wild. > What nobody knew was that the truck had no engine, no fuel cell, and no propulsion system of any kind. > Milton's team towed it to the top of a hill, tilted the camera to hide the slope, and let it roll. > He spent the next four years doing the same thing with words. On podcasts, television and social media. > Investors were told Nikola could produce its own hydrogen. It could not. They were told the trucks were ready for production. They were not. They were told orders were flooding in. They weren't. > In June 2020 Nikola went public. Within days the company was worth $30 BILLION, more than Ford. > Milton's personal stake hit $7.3 BILLION overnight. > A $32.5 MILLION ranch in Utah followed. A record for the state at the time. > In September 2020 Hindenburg Research published a report calling Nikola "an intricate fraud" built on "an ocean of lies." Milton resigned within ten days. > A federal jury convicted him of securities fraud and wire fraud in 2022. Sentenced to four years in prison the following year. > He never went. He was free on $100 MILLION bail pending appeal. > He and his wife donated $3.2 MILLION to Donald Trump's 2024 campaign. > In March 2025 Trump gave him a full pardon. The pardon erased $168 MILLION in restitution to defrauded shareholders. > Nikola filed for bankruptcy the following month, leaving thousands of investors with nothing. The company never had a product. The only thing that was real was the $30 BILLION valuation, the $7 BILLION that landed in his pocket and the pardon that made sure none of it had to be returned.

BREAKING: IMF warns new AI models risk ‘systemic’ shock to finance, per FT

Financial Times perfectly illustrates our possible futures

the american mind cannot understand this

It's that easy

Introducing SubQ - a major breakthrough in LLM intelligence. It is the first model built on a fully sub-quadratic sparse-attention architecture (SSA), And the first frontier model with a 12 million token context window which is: - 52x faster than FlashAttention at 1MM tokens - Less than 5% the cost of Opus Transformer-based LLMs waste compute by processing every possible relationship between words (standard attention). Only a small fraction actually matter. @subquadratic finds and focuses only on the ones that do. That's nearly 1,000x less compute and a new way for LLMs to scale.

Watch life expectancy going up.

I wonder what this looks like for the Web3 ecosystem

Insane stat: 0.1% of the accounts on Polymarket have earned 67% of the profits.