Been in SF for almost 2.5 years. And figured two types of people: Camp 1: Stanford or Berkeley? Which company? How much equity? Know any VCs? Camp 2: What’s the last thing that changed how you think? What problem are you obsessed with? What did you read last? One exhausts me. The other reminds me why I moved here. 😅

THAT WAS THE BEST FOOD IVE EVER HAD IN MY LIFE OMG 😭😭😭 VAMOSSS CHICHARRONNN! 😍

There was a 67 meetup in NYC at 6:07 PM on 06/07.

a reminder

The new Huberman Lab episode is out: Peptides: The Science, Uses & Safety | Dr. @AbudBakri 0:00 Abud Bakri 3:33 What are Peptides?, Receptors 6:26 BPC-157, Discovery, Animal Proteins 11:19 BPC-157, Animal Data, Regeneration 12:27 Sponsors: Eight Sleep & Lingo 14:51 BPC-157, Regeneration & Healing, Neurological Effects 19:27 Adverse Events, Clinical Trials & Legality of BPC-157 29:41 GLPs & Compounding Pharmacy; Peptides & Gray Market 35:25 Manufacturing, Compounding Pharmacies, Gray Market, Black Market 41:32 Peptides & Tumor Growth?; Angiogenesis 45:17 Sponsor: AG1 47:01 Pharmaceutical Patents, Clinical Trials for BPC-157, Potential Outcomes 54:19 BPC-157 Healing, Patient Experiences 1:01:22 Physician Counsel, FDA Legality, Malpractice 1:07:25 Pinealon, Epithalon, Discovery; Sleep & Cognitive Performance, Risks 1:18:17 Sponsor: Function 1:19:55 Pineal Age Deterioration, Epithalon, Eye Health 1:29:38 Thymus, Age Shrinkage; Thymosin Alpha-1, Immune Function 1:38:13 TB-500; Pet Health; Thymic Peptide Doses, Thymulin, Zinc 1:49:13 Sponsor: LMNT 1:50:33 GHK-Cu (Copper GHK), Collagen 1:55:32 Illness Recovery, Thymic Score, Tool: Blood Test & Immune Cell Counts 2:04:01 Growth Hormone Secretagogues, Age Decline, Cancer Risk, Insulin 2:15:36 GHK-Cu, Topical Cream, Red Light Therapy 2:20:25 GLPs, Discovery, Physical & Cognitive Long-Term Effects, Fertility 2:33:53 Retatrutide; Drug Patents & Nomenclature 2:39:03 Peptides: Women Reproductive Disorders; TBI, Neurologic Effect; Safe Sources 2:45:34 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.

everyone in austin loves partiful. why am i being sent a partiful for bookclub

Okay guys, had a few cultural shocks in Spain: > Go to the gym, opens 10am on a Sunday > Go to work from a coworking, closed > Go to a coffee shop, no wifi Absolutely unthinkable in a barely productive economy like the US, yet alone UAE. Europe is a daylight museum.

6 months ago, I moved to San Francisco. It’s the best place in the world to build, and one of the worst places to stay human. My unfiltered take: 1. SF is both overhyped and underrated The overhyped part: there are a lot of people with incredible resumes who are deeply unimpressive in real life. They were at the right company, at the right time, in the right market, and got carried by the wave. They made money, got comfortable, and now spend their time “exploring opportunities” over coffee, wasting your time. The underrated part: the top 1% here is insane. But almost impossible to get. Hiring in SF feels like being a guy on a dating app: everyone you want is out of your league, and everyone in your league wants someone out of theirs. The best people have unmatchable packages, endless options, and are optimizing for maximum impact: labs, frontier companies, or startups raising $100M pre-seed rounds. If you raised $10M from Tier 1 investors, you’re not hot shit here. You’re a B-player. It’s humbling. 2. There are fewer mission-driven people than I expected Especially on the application layer. A lot of people are in “secure the bag before it’s too late” mode. And honestly, it gives me the ick. The real religious builders I’ve met are often in labs, hardware, biotech, deeptech, defense — places where the work is hard enough that you can’t fake obsession. 3. The status game favors builders This is what SF does better than anywhere else. It rewards obsession. It rewards weirdness. It rewards people who make building their entire personality. Europe punishes that. SF gives it status. If you’ve felt like an outsider your whole life because you care too much, work too much, think too radically, or refuse to be chill about things that matter, this city will make you feel less insane. 4. The market liquidity is absurd Even if you don’t build a billion-dollar company, if you manage to build a strong product with a great team, someone smart might still acquire you for $ 100M. Yeah I know, it’s not your dream outcome as a founder, but on the days you feel desperate, it helps to keep going. 5. SF does not care about the meaning crisis that’s coming Anyone paying attention here can feel that something massive is happening with AI. But I’m shocked by how little people talk about the meaning crisis coming next. Everyone wants to talk about AI liberating humanity. Almost no one wants to talk about what happens when work — the thing that gives most people identity, structure, dignity, status, and purpose — starts disappearing. The vacuum will not be peaceful. People are underestimating the chaos that comes from humans suddenly having no idea why they matter. And I really feel like no one cares. 6. Personally, I’ve never been more unhappy I moved to SF and entered the matrix. I’ve always been intense. I’ve always worked crazy hours. But here, I lost the last parts of myself that were not about building. I don’t go to events. Most networking events feel like theater for people pretending to be important. The only events worth going to are small, curated dinners with people who are actually alive. I’ve made 0 real friends. I don’t do well with transactionality. I don’t do well with people constantly performing greatness. I don’t do well with rooms where everyone is optimizing and no one is being honest. So yes, SF is lonely, transactional, delusional, addictive, inspiring, boring, extraordinary, and completely insane. But it is still the only place to be right now if you’re a founder trying to build the next wave of humanity. And for now, that’s enough.

Spanish colonial homes were never just beautiful. They were built to survive heat. Thick lime walls that stay cool without AC. Deep verandas that kill direct sun. Terracotta roofs that breathe. Timber that ages into the building. Brazil, Colombia, Mexico built entire cities this way. Then “modern” came and replaced all of it with glass and concrete. The irony is we’re now paying to cool the buildings that replaced the ones that cooled themselves.