Professor of Biomedical Engineering at Duke University, Director of the Center for Advanced Genomic Technologies
Joined April 2011
- Tweets 155
- Following 114
- Followers 1,411
- Likes 117
13 Photos and videos
Pinned Tweet
2 Oct 2019
We're very excited to launch of the Duke Center for Advanced Genomic Technologies @DukeCAGT, a joint venture of @DukeEngineering @DukeMedSchool and @DukeTrinity. We are supporting collaborative research efforts to tackle grand challenges in genome sciences and engineering.
2
12
53
29 Jul 2024
We propose remaining challenges and opportunities for epigenome editing, and provide a future outlook. We are incredibly enthusiastic about the pace of new technology development in this area, the fundamental discoveries it is enabling, and what it can do for patients!
1
2
862
29 Jul 2024
Led by Sean McCutcheon, Dahlia Rohm, and Nahid Iglesias - we are thankful to the editors and reviewers for their contributions to enhancing this review.
3
593
29 Jul 2024
Epigenome editing is transforming biological sciences and medicine. We're grateful for the opportunity to publish this review of the field in @NatureBiotech. Check it out here: rdcu.be/dPjsJ
10
67
274
44,685
29 Jul 2024
We explain the technology and its context among other genome editing tools, provide a catalog of common epigenome editors, survey recent technical advances, and summarize use cases in functional genomics, cell engineering, and gene/cell therapy.
1
1
464
17 Nov 2023
Epigenetic control is incredibly powerful for bolstering cell therapy. We’re very excited to continue to build on the foundation established with this publication.
16 Nov 2023
Scientists have engineered a modified CRISPR technology targeting the epigenome capable of modulating T-cell behavior. In the process, they discovered a master regulator of the genome that reprograms T cells and enhances their cancer cell-killing ability. ow.ly/opgC50Q8lq0
8
24
4,167
Charles Gersbach retweeted
16 Nov 2023
Using a new CRISPR-based methodology, a team of researchers led by @cgersbach @DukeU has identified a “master regulator” gene capable of dramatically improving T-cell therapy performance >>> bit.ly/47vsnwN
3
3
579
Charles Gersbach retweeted
10 Nov 2023
Epigenetic CRISPR screening in human T cells reveals that BATF3 overexpression enhances T cell function, reduces exhaustion, and boosts CAR T cell potency in both in vitro and in vivo tumor models. #NBThighlight nature.com/articles/s41588-0…
2
56
197
36,730
9 Nov 2023
Very happy to share our latest work today in @NatureGenet - "Transcriptional and epigenetic regulators of human CD8 T cell function identified through orthogonal CRISPR screens" - led by @DukeUBME PhD student Sean McCutcheon. 1/n
nature.com/articles/s41588-0…
rdcu.be/dqHFO
6
20
148
17,573
9 Nov 2023
This is our first report of a broader active area within our research group on T cell engineering. We are excited to repurpose the tools and protocols developed here for improve ACT and CAR-T for diverse applications. We’re looking forward to sharing more on these efforts soon!
1
1
454
9 Nov 2023
We are incredibly thankful to our collaborators and co-authors, and our funding sources for supporting this new research direction! @somaticediting @ENCODE_NIH @IGVFConsortium @genome_gov @NSF @AllenInstitute @DukeU @DukeCAGT
2
441
9 Nov 2023
Looking forward to a great meeting!
8 Nov 2023
FGE23 @bitsgoa is less than a week away and the whole team @IGIBSocial is excited to welcome guests and participants from all over the world! @BKleinstiver @palermo_lab @randall_platt @cgersbach @AngelaEGGLEST17 @XueSherryGao @Ajit_IISER @MohankumarKMur1 @WeixinT @KomorLab
3
884