Lab of Dr. Alexis Komor at the University of California, San Diego | Precision Genome Editing The Chemical Biology of DNA Damage and Repair

Joined January 2019
60 Photos and videos
Pinned Tweet
10 Jun 2020
In observance of of #ShutDownSTEM we have drafted a Statement of Support for the #BLM movement with a list of actions we will take to combat racism and enforce equity and diversity in our community #BlackLivesMatter #ShutDownAcademia @UCSDChemBiochem @AcademicChatter @UCSDPhySci
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Komor Lab retweeted
Precise, minimally evolved adenine base editors generated through mutation reversion analysis go.nature.com/4rHWkmu
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Congrats to @UCSDAstro's Dusan Keres and @KomorLab on making the 2025 list of #HighlyCitedResearchers for their contributes extending the frontiers of knowledge and to innovations that make the world healthier and more sustainable.” @UCSDChemBiochem bit.ly/47Ozx1F
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Komor Lab retweeted
Excited to share my talk hosted by UCTV "A Closer Look at…Genetic Medicine and Artificial Intelligence" discussing RNA, AI and genetic medicine. Together with @KomorLab youtu.be/SSpE8BNOebg?si=5LQ5… via @YouTube

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Komor Lab retweeted
.@SecKennedy - thank you so much for your broad support for gene editing and gene therapies as well as recognizing the importance of Baby KJ’s story and the potential that CRISPR base editing therapies hold for patients with severe genetic diseases. I’m thrilled you have publicly recognized the Herculean efforts that made KJs therapy possible, from the physicians @CHOP like @kiranmusunuru and Rebecca Ahrens-Nicklas to the technological innovation in @davidrliu and @BKleinstiver labs, and especially the coordination and cooperation of the regulators @US_FDA that made this possible. The gene editing medicine KJ received, a CRISPR adenine base editor was invented and developed in @davidrliu lab @Harvard with government grants from the NIH. This life-saving medicine, and so many future technologies, could not and will not be possible without government grants such as the one that supported this work, but are now shut off by this administration. So PLEASE ask this administration to stop attacking our academic institutions and restore government funding to @Harvard (where again, KJ’s medicine was created!!) We cannot have stories like KJ’s without full and unwavering support from the US government. Please help, please.
Thursday morning, I had the privilege of speaking with the Muldoon family, whose 10-month-old son, baby KJ, was discharged Wednesday from @ChildrensPhila. Baby KJ was diagnosed with a rare urea cycle disorder and received a first-of-its-kind personalized CRISPR gene-editing therapy—customized specifically for his unique mutation. Thanks to the extraordinary expertise and compassion of the team at CHOP and the researchers who developed this pioneering treatment, baby KJ now has a second chance at life. The Muldoon family’s courage is nothing short of inspiring, and I offer my deepest gratitude to everyone at CHOP and beyond who made this medical milestone possible. This isn’t just a medical success story—it’s a powerful glimpse into the future of personalized medicine. I remain firmly committed to working with @NIHDirector_Jay, @DrMakaryFDA, @DrOzCMS, and others to ensure that: • HHS continues to invest in cutting-edge research that drives breakthrough therapies • Our regulatory frameworks keep pace with rapid innovation • No family is ever denied access to life-saving treatments because of cost Breakthroughs like this are why we do the work.
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1 Nov 2024
Ten scientists are leading a new generation of gene editors developing CRISPR medicines. Names include @KomorLab, @jgooten, @omarabudayyeh, @pdhsu, and @bsadamson. See the full list here: trib.al/AkCuGIp
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31 Oct 2024
Thank you @MeganMolteni for including me in this amazing lineup of scientists!
.@MeganMolteni's pitch-perfect lineup of the best talent in clinic-enabling gene editing - study their papers as a masterclass and rejoice. @KomorLab @MarsonLab @pdhsu @bsadamson @BKleinstiver @kiranmusunuru @cgersbach @sahakris statnews.com/2024/10/31/who-…
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27 Oct 2024
The impact of CRISPR genome editing transcends potential cures. It's changing our understanding of what drives cancer and new ways to intervene @ScienceMagazine by @KomorLab and colleagues science.org/doi/10.1126/scie…
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Komor Lab retweeted
Congratulations to @davidrliu for being awarded the 2024 A.I. Scott medal in Chemistry. It was also the first time all four of us presented at the same event! @KomorLab
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Komor Lab retweeted
Research Highlight by @madhuramukho: Multiplexed Orthogonal Base Editor (MOBE) systems developed by @komorlab, @quinn_cowan_sci & colleagues is a suite of tools that use RNA aptamer systems to enable simultaneous distinct point mutations at different loci. nature.com/articles/s41592-0…

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Komor Lab retweeted
Thank you @naturemethods @madhuramukho for highlighting our research: Development of Multiplexed Orthogonal Base Editor (MOBE) systems! 🧬@KomorLab @UCSDChemBiochem @UCSDPhySci nature.com/articles/s41592-0…

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Komor Lab retweeted
Base editing can introduce a precise mutation into the genome. But what if one wants to make multiple different types of base edits at the same time? That’s why @KomorLab from @UCSDPhySci created MOBE, a multiplexed base editing toolkit. bit.ly/4ctUtLg
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Komor Lab retweeted
Development of multiplexed orthogonal base editor (MOBE) systems go.nature.com/3K8Kfn1
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Excited my PhD work is out now @NatureBiotech! We report Multiplexed Orthogonal Base Editor (MOBE) systems: tools to simultaneously install distinct point mutations. MOBEs introduce co-occurring genetic variants (polygenic disease, haplotypes)🧬 🧵⬇️ 1/ go.nature.com/3K8Kfn1
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2 May 2024
Congrats to Dr. Cowan @Quinn_Cowan_sci who just defended his thesis! He aptly celebrated the occasion with a lei made of the flow cells from his HTS runs. Be on the lookout for his paper, which is coming out soon! 👀🎉
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Komor Lab retweeted
Huge thanks to our collaborators @KomorLab and Rahul Kohli, who were instrumental in this work. We also thank @NatureComms for the opportunity to publish our work!
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22 Aug 2023
Congrats to Dr. Ranzau @brodieranzau who defended his thesis yesterday! If you haven’t yet checked out his awesome work detecting DNA editing activity by wtTAdA, give it a read here: chemistry-europe.onlinelibra…
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25 Jul 2023
Congrats to Dr. Porto @ElizabethMPorto who defended her thesis today! Next up she is heading to Boston to start a job as a life sciences consultant at Clarion!!
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Komor Lab retweeted
So delighted to welcome our 1st Holland Award recipients to the #CottrellScholar community! Luis Colón @LuisColonLab, Raychelle Burks @DrRubidium, Jane Liu @pomonacollege, Malika Jeffries-El @Chem_Diva, Ted Goodson @MichiganChem & Robert Gilliard @rjgilliard.
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22 Jul 2023
It’s always a fun, insightful, and thought-provoking time when @RCSA1 holds a conference. Got some really great ideas for promoting cultural change, thanks so much to @jenheemstra @TehshikYoon and our fearless leader @ronco_sronco for leading/organizing!
Had some great discussions at my first @RCSA1 #CottrellScholar Conference! Got to catch up with @UCSDPhySci @UCSDPhysics @UCSDChemBiochem colleagues @markherzik @KomorLab Alex Fraño and Lena Koslover and meet a lot of new people
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Looks like the newest members of the #CottrellScholar community are ready to incentivize some cultural change! Thanks to EVERYONE for a great conference.
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