Assistant professor @Duke, guerilla knitter, pipettor of small volumes of liquid. Biologist masquerading as engineer, or the other way around.

Joined November 2009
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Evolution navigated billions of challenges to get to us to where we are today. Directed evolution compresses this to 1D axis. Imagine if you could sample 200 dimensions at once, with data to boot šŸ“ˆ First @chorylab PACE preprint on our new system to tackle this: TurboPRANCEšŸ‘‡
Aaaand it’s online ahhhhh!!! 🄳🄳 So excited!! The first glimpse of my postdoc work with @chorye @dukecagt. Here, @stefanmgolas and I developed TurboPRANCE, an open-source robotics platform for rapid and scaled phage-assisted continuous evolutions. 🧪Tweetorial party!šŸ‘‡1/n
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Emma J Chory retweeted
A grant cap tells scientists there is a limit to their discoveries. The entire capitalist critique of communism is literally that when you put ceilings on what people are allowed to aspire to, collective ambition shrinks, and innovation becomes less likely. I would really encourage people to do a quick RePORTER search for a few HHMI faculty or recipients of NIH Pioneer, Transformative Research R01, or Outstanding Investigator R35 awards, and look at how many NIH grants they had when they reached that level.
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Deeply honored to be named a 2026 Beckman Young Investigator #BYI!🧬 This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.
Congratulations to our 2026 Beckman Young Investigator Awardees! Twelve Researchers Selected to Receive $7.2M in Total Science Funding for Cutting-edge Research beckman-foundation.org/lates… #beckmanresearch #newlyawarded
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In other news, today the NIH proposed caping the maximum of grants at 2 per research lab, including collaborations. grants.nih.gov/grants/guide/… We're living in the upside down.

Replying to @peterottsjo
Lila Sciences may raise about $2 billion at an $8.5 billion valuation. That number looks incredible if you treat Lila as a normal AI biotech. It makes a little more sense (maybe!) if you treat it as a bet on a new R&D operating system. Lila’s pitch is AI Science Factories: AI systems connected to automated labs that generate hypotheses, design experiments, run them, learn from the results, and repeat. In other words: model, robot lab, experiment, data, repeat. The whole shebang. Or ā€œscientific superintelligenceā€ and ā€œoperating system for science," as Lila calls it. (3/7)
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I encourage everyone who is deeply concerned about this proposal to submit a public comment by Aug 3, here: rfi.grants.nih.gov/?s=6a1f20…

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Asked 3 different science AIs ( Claude) the same question today: what’s the best/most current PMCID citation for the number of cancer deaths per annum from solid tumors. The only good answer still came from texting the neurosurgeon whose office is next door.
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This is a horrifically dumb take even for @BiotechMongoose. Even when the odds are long, and not in your favor, these awards matter. They give young scientists ambitious, almost impossible goals to aim for. Their impact is not only on the few people who win, but on everyone who stretches toward that standard, pushing science forward. When these opportunities disappear, so do the aspirations they inspire.
Counterpoint: it, like virtually all the early-independence awards, is biased toward the well-connected and the exceptionally lucky, and more importantly, the people it goes to weren't going to leave biosci because they were already virtually all anointed.
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Emma J Chory retweeted
very sad! the DP5 grant launched my academic career
This one is hard to see. The NIH Early Independence Award, one of the most competitive grants in the country for young scientists, will not go forward in FY2026. NIH says this is due to ā€œadministrative changes to funding opportunity processing and delays in approvals.ā€
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This one is hard to see. The NIH Early Independence Award, one of the most competitive grants in the country for young scientists, will not go forward in FY2026. NIH says this is due to ā€œadministrative changes to funding opportunity processing and delays in approvals.ā€
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Meanwhile, this administration and their talking heads keep spewing empty phrases about investing in science and supporting the next generation. Grants are still "delayed," if they come at all. Labs are still laying people off. And programs like this are being ended through quiet website notices and footnotes that most people will never see, while whole careers evaporate.
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This is what the future of American science looks like, and frankly, it is bleak. commonfund.nih.gov/earlyinde…

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Emma J Chory retweeted
Screen 1M random protein sequences to discover that biology-like folds are accessible from random sequences with surprising frequency @KlaraH_lab
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Emma J Chory retweeted
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? Come hear about STRAIGHT-IN Dual now out at Nature Biomedical Engineering! 🧵 Link at end!
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Another important step in the fight toward eliminating Lyme disease. šŸ­šŸ•·ļø This paper from my postdoc lab shows progress toward engineering mice so they can no longer transmit the bacteria that cause Lyme disease. By targeting the animal reservoir, this approach could help break the cycle that keeps Lyme circulating in the wild. Paper here: nature.com/articles/s41467-0… Great to see this work out in @NatureComms. Congrats to @JoannaBuchthal, @kesvelt and the rest of the Mice Against Ticks team.
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Emma J Chory retweeted
The 2026 Breakthrough Prize ceremony (ā€œthe Oscars for scienceā€) celebrated the achievements of many remarkable scientists and their students and collaborators last weekend. Here’s the video of the show: youtu.be/_CZHeEyZBU0?si=blLQ…. And here’s the segment in which Anne Hathaway and Alex Honnold (who climbed El Capitan free solo) presented the story of baby K.J.’s base editing treatment and introduced Kiran Musunuru, Rebecca Ahrens-Nicklas, Peter Marks, baby K.J. and his wonderful family, and myself: youtu.be/_CZHeEyZBU0?si=blLQ…
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Emma J Chory retweeted
Found a tick after hugging Daphne following a morning run. Thanks to @JoannaBuchthal & our collaborators, we can now engineer animals to resist Lyme disease. But until we immunize the wild white-footed mice that carry it, we’re stuck with tick checks. nature.com/articles/s41467-0…
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