Assistant Prof @MITChemE ; mom^4 wife; enjoys building cell-fate circuits, exploring dna topology, reprogramming the living world, and soccer; soli gloria deo
Joined June 2019
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Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
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Katie Galloway retweeted
I'm hiring a research tech soon for my lab at Harvard Med, starting this fall. We'll work on designing microbes and proteins with New-to-Nature functions.
Ideal for a recent grad seeking hands-on research & opportunity to publish before PhD.
Job ad soon. RTs much appreciated!
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Someone needs to pseudotime this UMAP
Paging @lpachter
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Jun 13
is everyone else just realizing that "certified" NIH biosketches can't be merged with other pdfs?
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From now on, if people ask me whose lab I'm in, I'm just going to say Galloway Lab and ramble on about what an amazing advisor I have...
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May 30
Meteor explodes off Massachusetts coast, causing loud boom, meteorologist confirms cbsnews.com/boston/news/mass…
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Katie Galloway retweeted
May 30
Did anyone else in Cambridge/Boston just hear what sounded like a loud boom and rumble? Like an explosion or large object falling?
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May 30
it is Atlases all the way down
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May 27
Graduation and hooding for these three Galloway Lab PhDs! Congrats, Brittany, Sneha, and Chris! Excelsior!
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May 27
Nifty work on plasmid chromatinization from @stergachislab !
"plasmids are indeed capable of recapitulating nuclear genome-encoded chromatin architectures, ... However, plasmids consistently adopt a heterogeneous and incomplete chromatin architecture relative to nuclear-encoded chromatin fibers, and surrounding sequence context plays an integral role in modulating whether a plasmid-encoded regulatory element will recapitulate nuclear genome-encoded chromatin architectures."
May 26
Online Now: Chromatin architectures underlying plasmid-based assays for regulatory variant effects dlvr.it/TSkLhj
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Katie Galloway retweeted
May 25
Excited to share our preprint on autonomous feedback control in synthetic receptor systems.
We engineered a miRNA-based negative feedback circuit where synNotch activation drives expression of a synthetic miRNA that represses the receptor itself.
Preprint: tinyurl.com/52adskww
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May 20
In case you're wondering if science twitter is dead, here it lives 😂
Broke: all vertebrates evolved from fish.
Woke: fish evolved from amphibi-birds.
Bespoke: Viruses evolved from nematodes.
Galaxy-brain-oke: Drosophila is a plant.
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Katie Galloway retweeted
May 14
🚨What if we could reliably program macrophage polarization state?🚨
biorxiv.org/content/10.64898…
Macrophages are highly plastic immune cells that perform critical functions by polarizing into distinct cellular states. The polarization state of macrophages can substantially influences the progression of cancers, infections, and autoimmunity. (1/11)
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May 14
Want the precision and control of RNA devices but not sure how to engineer your lenti to deliver them?
🚨new pre-print from @kaseyslove🚨
hint: syntax matters! 👇
Engineering high-titer lentiviral vectors for robust expression of RNA-based gene circuits biorxiv.org/content/10.64898… #biorxiv_synbio
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